Department of Economics and Business Economics

Smokin` hot: adolescent smoking and the risk of psychosis

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • A Mustonen, Research Center for Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland; Department of Internal Medicine, Oulu University Hospital, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland;
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  • T Ahokas, Center for Life Course Health Research, University of Oulu, Oulu, Finland.
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  • T Nordström, Research Center for Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland; Department of Internal Medicine, Oulu University Hospital, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland;
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  • G K Murray, Department of Psychiatry, University of Cambridge
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  • P Mäki, Department of Psychiatry, Kainuu Central Hospital, Kainuu Social and Healthcare District, Kajaani, Finland.
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  • E Jääskeläinen, Center for Life Course Health Research, University of Oulu, Oulu, Finland., Research Center for Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland; Department of Internal Medicine, Oulu University Hospital, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland;, Department of Psychiatry, Oulu University Hospital, the Northern Ostrobothnia Hospital District, Oulu, Finland.
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  • A Heiskala, Center for Life Course Health Research, University of Oulu, Oulu, Finland.
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  • J J Mcgrath
  • J G Scott, Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD, 4072, Australia., Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Herston, QLD, Australia. j.kesby@uq.edu.au., The University of Queensland, UQ Centre for Clinical Research, Herston, Queensland 4029, Australia; Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD 4076, Australia; Metro North Mental Health, Royal Brisbane and Women's Hospital, Herston, Queensland 4029, Australia. Electronic address: james.scott@health.qld.gov.au.
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  • J Miettunen, Research Center for Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland; Department of Internal Medicine, Oulu University Hospital, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland;
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  • S Niemelä, Department of Psychiatry, Lapland Hospital District, Rovaniemi, Finland.

OBJECTIVE: Daily smoking has been associated with a greater risk of psychosis. However, we are still lacking studies to adjust for baseline psychotic experiences and other substance use. We examined associations between daily smoking and psychosis risk in a 15-year follow-up while accounting for these covariates in a prospective sample (N = 6081) from the Northern Finland Birth Cohort 1986.

METHODS: Self-report questionnaires on psychotic experiences (PROD-screen), tobacco smoking and other substance use were completed when the cohort members were 15-16 years old. Tobacco smoking was categorized into three groups (non-smokers, 1-9 cigarettes and ≥10 cigarettes/day). Psychosis diagnoses were obtained from national registers until the age of 30 years.

RESULTS: Subjects in heaviest smoking category were at increased risk of subsequent psychosis (unadjusted HR = 3.15; 95% CI 1.94-5.13). When adjusted for baseline psychotic experiences the association persisted (HR = 2.87; 1.76-4.68) and remained significant even after adjustments for multiple known risk factors such as cannabis use, frequent alcohol use, other illicit substance use, parental substance abuse, and psychosis. Furthermore, number of smoked cigarettes increased psychosis risk in a dose-response manner (adjusted OR = 1.05; 1.01-1.08).

CONCLUSION: Heavy tobacco smoking in adolescence was associated with a greater risk for psychosis even after adjustment for confounders.

Original languageEnglish
JournalActa Psychiatrica Scandinavica
Volume138
Issue1
Pages (from-to)5-14
Number of pages10
ISSN0001-690X
DOIs
Publication statusPublished - 2018

    Research areas

  • ASSOCIATIONS, CANNABIS, CIGARETTE-SMOKING, EXPERIENCES, PRODROMAL SYMPTOMS, SCHIZOPHRENIA, TOBACCO SMOKING, YOUNG-ADULTS, epidemiology, nicotine, psychosis, schizophrenia, tobacco

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