@inbook{e9ea3468e949487ab24cf620e568bcbe,
title = "Small Paramagnetic Co-solute Molecules",
abstract = "Small co-solute molecules containing unpaired electrons can impart strong perturbations on nuclear shielding and nuclear relaxation of dissolved compounds, and thereby form a potent class of non-covalent probes for molecular science. These paramagnetic co-solutes range from exquisite lanthanoid and transition metal complexes to a molecule as simple as dioxygen. In this chapter, we discuss the various effects that can be observed due to paramagnetic co-solutes, and we highlight how these effects have spurred the buildout of their application to protein science. For example, dioxygen is a very sensitive probe able to identify internal cavities in proteins, whereas neutral gadolinium chelates have become key in the structure determination of protein complexes in solution.",
author = "Tobias Madl and Mulder, {Frans A.A.}",
year = "2018",
month = jan,
day = "1",
doi = "10.1039/9781788013291-00283",
language = "English",
isbn = "978-1-78801-086-3",
volume = "2018/16",
series = "New Developments in NMR",
publisher = "Royal Society of Chemistry",
pages = "283--309",
editor = "Luchinat, {Claudio } and Parigi, {Giacomo } and Ravera, {Enrico }",
booktitle = "Paramagnetism in Experimental Biomolecular NMR",
}