Small but mighty: Case report and practical guidance for peripheral blood stem cell collection in small infants

Hannah Walker; Erin O'Reilly; Zoe Millard; Brendan Cusack; Anna Duncan; Luisa Clucas; Jacqueline Fleming; David Hughes; Anthea Greenway; David Metz

doi:10.1002/jca.22141

Small but mighty: Case report and practical guidance for peripheral blood stem cell collection in small infants

Hannah Walker^*, Erin O'Reilly, Zoe Millard, Brendan Cusack, Anna Duncan, Luisa Clucas, Jacqueline Fleming, David Hughes, Anthea Greenway, David Metz

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

Modern apheresis devices, with increased procedural precision, automation, and monitoring, have been shown to allow for safe delivery of apheresis therapies in young children. Medical advances are increasing demand for apheresis procedures like mononuclear cell collection in infants <10 kg, including stem-cell supported chemotherapy, cell collection for chimeric antigen receptor T cell development, and now ex vivo gene therapies for rare genetic diseases. Nevertheless, safe delivery in small infants involves a range of unique considerations and challenges, beyond just size, and experience will vary between centers. In this case report we describe our experience performing mononuclear cell collection in our smallest patient to date and outline a practice guideline developed following a literature review and discussion with both international experts and device representatives. This case may help to inform other clinicians aiming to provide apheresis care to very small infants in their own centers.

Original language	English
Article number	e22141
Journal	Journal of Clinical Apheresis
Volume	39
Issue	4
Number of pages	8
ISSN	0733-2459
DOIs	https://doi.org/10.1002/jca.22141
Publication status	Published - Aug 2024
Externally published	Yes

Keywords

apheresis
pediatric
peripheral blood stem cell

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10.1002/jca.22141

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title = "Small but mighty: Case report and practical guidance for peripheral blood stem cell collection in small infants",

abstract = "Modern apheresis devices, with increased procedural precision, automation, and monitoring, have been shown to allow for safe delivery of apheresis therapies in young children. Medical advances are increasing demand for apheresis procedures like mononuclear cell collection in infants <10 kg, including stem-cell supported chemotherapy, cell collection for chimeric antigen receptor T cell development, and now ex vivo gene therapies for rare genetic diseases. Nevertheless, safe delivery in small infants involves a range of unique considerations and challenges, beyond just size, and experience will vary between centers. In this case report we describe our experience performing mononuclear cell collection in our smallest patient to date and outline a practice guideline developed following a literature review and discussion with both international experts and device representatives. This case may help to inform other clinicians aiming to provide apheresis care to very small infants in their own centers.",

keywords = "apheresis, pediatric, peripheral blood stem cell",

author = "Hannah Walker and Erin O'Reilly and Zoe Millard and Brendan Cusack and Anna Duncan and Luisa Clucas and Jacqueline Fleming and David Hughes and Anthea Greenway and David Metz",

note = "{\textcopyright} 2024 The Author(s). Journal of Clinical Apheresis published by Wiley Periodicals LLC.",

year = "2024",

month = aug,

doi = "10.1002/jca.22141",

language = "English",

volume = "39",

journal = "Journal of Clinical Apheresis",

issn = "0733-2459",

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number = "4",

}

Small but mighty: Case report and practical guidance for peripheral blood stem cell collection in small infants. / Walker, Hannah; O'Reilly, Erin; Millard, Zoe et al.
In: Journal of Clinical Apheresis, Vol. 39, No. 4, e22141, 08.2024.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Small but mighty

T2 - Case report and practical guidance for peripheral blood stem cell collection in small infants

AU - Walker, Hannah

AU - O'Reilly, Erin

AU - Millard, Zoe

AU - Cusack, Brendan

AU - Duncan, Anna

AU - Clucas, Luisa

AU - Fleming, Jacqueline

AU - Hughes, David

AU - Greenway, Anthea

AU - Metz, David

PY - 2024/8

Y1 - 2024/8

N2 - Modern apheresis devices, with increased procedural precision, automation, and monitoring, have been shown to allow for safe delivery of apheresis therapies in young children. Medical advances are increasing demand for apheresis procedures like mononuclear cell collection in infants <10 kg, including stem-cell supported chemotherapy, cell collection for chimeric antigen receptor T cell development, and now ex vivo gene therapies for rare genetic diseases. Nevertheless, safe delivery in small infants involves a range of unique considerations and challenges, beyond just size, and experience will vary between centers. In this case report we describe our experience performing mononuclear cell collection in our smallest patient to date and outline a practice guideline developed following a literature review and discussion with both international experts and device representatives. This case may help to inform other clinicians aiming to provide apheresis care to very small infants in their own centers.

AB - Modern apheresis devices, with increased procedural precision, automation, and monitoring, have been shown to allow for safe delivery of apheresis therapies in young children. Medical advances are increasing demand for apheresis procedures like mononuclear cell collection in infants <10 kg, including stem-cell supported chemotherapy, cell collection for chimeric antigen receptor T cell development, and now ex vivo gene therapies for rare genetic diseases. Nevertheless, safe delivery in small infants involves a range of unique considerations and challenges, beyond just size, and experience will vary between centers. In this case report we describe our experience performing mononuclear cell collection in our smallest patient to date and outline a practice guideline developed following a literature review and discussion with both international experts and device representatives. This case may help to inform other clinicians aiming to provide apheresis care to very small infants in their own centers.

KW - apheresis

KW - pediatric

KW - peripheral blood stem cell

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U2 - 10.1002/jca.22141

DO - 10.1002/jca.22141

M3 - Journal article

C2 - 39060110

SN - 0733-2459

VL - 39

JO - Journal of Clinical Apheresis

JF - Journal of Clinical Apheresis

IS - 4

M1 - e22141

ER -

Small but mighty: Case report and practical guidance for peripheral blood stem cell collection in small infants

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Keywords

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