Small-angle X-ray and neutron scattering

Cy M. Jeffries; Jan Ilavsky; Anne Martel; Stephan Hindrichs; Andreas Meyer; Jan Skov Pedersen; Anna V. Sokolova; Dmitri I Svergun

doi:10.1038/s43586-021-00064-9

Small-angle X-ray and neutron scattering

Cy M. Jeffries^*, Jan Ilavsky, Anne Martel, Stephan Hindrichs, Andreas Meyer, Jan Skov Pedersen, Anna V. Sokolova, Dmitri I Svergun^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

113 Citations (Scopus)

Abstract

Small-angle scattering (SAS) is a technique that is able to probe the structural organization of matter and quantify its response to changes in external conditions. X-ray and neutron scattering profiles measured from bulk materials or materials deposited at surfaces arise from nanostructural inhomogeneities of electron or nuclear density. The analysis of SAS data from coherent scattering events provides information about the length scale distributions of material components. Samples for SAS studies may be prepared in situ or under near-native conditions and the measurements performed at various temperatures, pressures, flows, shears or stresses, and in a time-resolved fashion. In this Primer, we provide an overview of SAS, summarizing the types of instrument used, approaches for data collection and calibration, available data analysis methods, structural information that can be obtained using the method, and data depositories, standards and formats. Recent applications of SAS in structural biology and the soft-matter and hard-matter sciences are also discussed.

Original language	English
Article number	70
Journal	Nature Reviews Methods Primers
Volume	1
Issue	1
Number of pages	39
ISSN	2662-8449
DOIs	https://doi.org/10.1038/s43586-021-00064-9
Publication status	Published - 12 Oct 2021

Access to Document

10.1038/s43586-021-00064-9

Cite this

@article{84f9cc9744b94de1a4f90ca2b263da86,

title = "Small-angle X-ray and neutron scattering",

abstract = "Small-angle scattering (SAS) is a technique that is able to probe the structural organization of matter and quantify its response to changes in external conditions. X-ray and neutron scattering profiles measured from bulk materials or materials deposited at surfaces arise from nanostructural inhomogeneities of electron or nuclear density. The analysis of SAS data from coherent scattering events provides information about the length scale distributions of material components. Samples for SAS studies may be prepared in situ or under near-native conditions and the measurements performed at various temperatures, pressures, flows, shears or stresses, and in a time-resolved fashion. In this Primer, we provide an overview of SAS, summarizing the types of instrument used, approaches for data collection and calibration, available data analysis methods, structural information that can be obtained using the method, and data depositories, standards and formats. Recent applications of SAS in structural biology and the soft-matter and hard-matter sciences are also discussed.",

author = "Jeffries, {Cy M.} and Jan Ilavsky and Anne Martel and Stephan Hindrichs and Andreas Meyer and Pedersen, {Jan Skov} and Sokolova, {Anna V.} and Svergun, {Dmitri I}",

year = "2021",

month = oct,

day = "12",

doi = "10.1038/s43586-021-00064-9",

language = "English",

volume = "1",

journal = "Nature Reviews Methods Primers",

issn = "2662-8449",

publisher = "Springer Nature",

number = "1",

}

TY - JOUR

T1 - Small-angle X-ray and neutron scattering

AU - Jeffries, Cy M.

AU - Ilavsky, Jan

AU - Martel, Anne

AU - Hindrichs, Stephan

AU - Meyer, Andreas

AU - Pedersen, Jan Skov

AU - Sokolova, Anna V.

AU - Svergun, Dmitri I

PY - 2021/10/12

Y1 - 2021/10/12

N2 - Small-angle scattering (SAS) is a technique that is able to probe the structural organization of matter and quantify its response to changes in external conditions. X-ray and neutron scattering profiles measured from bulk materials or materials deposited at surfaces arise from nanostructural inhomogeneities of electron or nuclear density. The analysis of SAS data from coherent scattering events provides information about the length scale distributions of material components. Samples for SAS studies may be prepared in situ or under near-native conditions and the measurements performed at various temperatures, pressures, flows, shears or stresses, and in a time-resolved fashion. In this Primer, we provide an overview of SAS, summarizing the types of instrument used, approaches for data collection and calibration, available data analysis methods, structural information that can be obtained using the method, and data depositories, standards and formats. Recent applications of SAS in structural biology and the soft-matter and hard-matter sciences are also discussed.

AB - Small-angle scattering (SAS) is a technique that is able to probe the structural organization of matter and quantify its response to changes in external conditions. X-ray and neutron scattering profiles measured from bulk materials or materials deposited at surfaces arise from nanostructural inhomogeneities of electron or nuclear density. The analysis of SAS data from coherent scattering events provides information about the length scale distributions of material components. Samples for SAS studies may be prepared in situ or under near-native conditions and the measurements performed at various temperatures, pressures, flows, shears or stresses, and in a time-resolved fashion. In this Primer, we provide an overview of SAS, summarizing the types of instrument used, approaches for data collection and calibration, available data analysis methods, structural information that can be obtained using the method, and data depositories, standards and formats. Recent applications of SAS in structural biology and the soft-matter and hard-matter sciences are also discussed.

UR - http://www.scopus.com/inward/record.url?scp=85119447216&partnerID=8YFLogxK

U2 - 10.1038/s43586-021-00064-9

DO - 10.1038/s43586-021-00064-9

M3 - Journal article

SN - 2662-8449

VL - 1

JO - Nature Reviews Methods Primers

JF - Nature Reviews Methods Primers

IS - 1

M1 - 70

ER -

Small-angle X-ray and neutron scattering

Abstract

Access to Document

Other files and links

Fingerprint

Cite this