Sleep-administered ketamine/psychedelics: A streamlined strategy to address two challenges in research on ketamine and psychedelics

Shokouh Arjmand; Mats B Lindström; Carl M Sellgren; Gregers Wegener

doi:10.1192/j.eurpsy.2025.14

Sleep-administered ketamine/psychedelics: A streamlined strategy to address two challenges in research on ketamine and psychedelics

Shokouh Arjmand, Mats B Lindström, Carl M Sellgren, Gregers Wegener

Department of Clinical Medicine - Translational Neuropsychiatry Unit

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

The dissociative effects of ketamine and psychedelics might be associated with their rapid antidepressant properties, raising questions about whether these effects are necessary for their therapeutic action. Additionally, the distinct dissociative experiences often reported by patients in clinical trials may reveal whether they receive an active treatment or a placebo, potentially introducing bias into the results. In this viewpoint, we propose administering ketamine/psychedelics to patients during sleep, offering a novel approach to address and explore these challenges.

Original language	English
Article number	e29
Journal	European psychiatry : the journal of the Association of European Psychiatrists
Volume	68
Issue	1
Pages (from-to)	1-5
Number of pages	5
ISSN	0924-9338
DOIs	https://doi.org/10.1192/j.eurpsy.2025.14
Publication status	Published - 5 Feb 2025

Keywords

blinding
ketamine
mechanism of action
psychedelics
rapid-Acting antidepressants

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10.1192/j.eurpsy.2025.14

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abstract = "The dissociative effects of ketamine and psychedelics might be associated with their rapid antidepressant properties, raising questions about whether these effects are necessary for their therapeutic action. Additionally, the distinct dissociative experiences often reported by patients in clinical trials may reveal whether they receive an active treatment or a placebo, potentially introducing bias into the results. In this viewpoint, we propose administering ketamine/psychedelics to patients during sleep, offering a novel approach to address and explore these challenges.",

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Sleep-administered ketamine/psychedelics: A streamlined strategy to address two challenges in research on ketamine and psychedelics. / Arjmand, Shokouh; Lindström, Mats B; Sellgren, Carl M et al.
In: European psychiatry : the journal of the Association of European Psychiatrists, Vol. 68, No. 1, e29, 05.02.2025, p. 1-5.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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Sleep-administered ketamine/psychedelics: A streamlined strategy to address two challenges in research on ketamine and psychedelics

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