Site-specific delivery of epigenetic modulating drugs into the rat brain

Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

1 Citation (Scopus)

Abstract

Site-specific injection of epigenetic modulating drugs into the brain, using neurostereotaxic surgery, is a very valuable experimental tool. This technique enables the pharmacological manipulation of targeted molecules, such as DNMT and HDAC, in specific brain areas, in conscious animals. This chapter presents a step-by-step description of cannula implantation in targeted brain structures and microinjection using neurostereotaxic surgery.

Original languageEnglish
Title of host publicationNeuromethods
Number of pages11
PublisherHumana Press Inc
Publication date2016
Pages149-159
DOIs
Publication statusPublished - 2016
SeriesNeuromethods
Volume105
ISSN0893-2336

Keywords

  • Microinjection
  • Site-specific injection
  • Stereotaxic surgery

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