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Should internal mammary lymph node sentinel biopsy be performed in breast cancer: a systematic review and meta-analysis

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Should internal mammary lymph node sentinel biopsy be performed in breast cancer : a systematic review and meta-analysis. / Gong, Jing; Yu, Yongfu; Wu, Gaosong; Lin, Congyao; Tu, Xin.

In: World Journal of Surgical Oncology, Vol. 17, No. 1, 135, 05.08.2019.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

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Gong, Jing ; Yu, Yongfu ; Wu, Gaosong ; Lin, Congyao ; Tu, Xin. / Should internal mammary lymph node sentinel biopsy be performed in breast cancer : a systematic review and meta-analysis. In: World Journal of Surgical Oncology. 2019 ; Vol. 17, No. 1.

Bibtex

@article{e9f4d2a92c344019b8ecf423fa3bee89,
title = "Should internal mammary lymph node sentinel biopsy be performed in breast cancer: a systematic review and meta-analysis",
abstract = "PURPOSE: Results from studies of internal mammary lymph node sentinel biopsy are inconsistent.METHODS: A comprehensive literature search was conducted in MEDLINE, EMBASE, Scopus, Cochrane database, and Clinical Trials. Studies reporting the rate of internal mammary lymph node sentinel biopsy (IMN-SLNB) positivity were identified. We performed pooled proportion meta-analysis using random-effects meta-analyses. The correlation of IMN and axillary lymph node (AXN) metastasis was also investigated.RESULTS: After application of inclusion and exclusion criteria, a total of 18 articles (total number of patients = 2427) were included. The pooled estimate for IMN-SLNB positivity rate was 15% (95% confidence interval (CI) 12-17%). Significant between-study heterogeneity was observed. Our results indicate that axillary lymph node metastasis is a strong predictor of IMN involvement (OR 6.01, 95% CI, 3.49, 10.34).CONCLUSION: Internal mammary lymph nodes metastasis might be underestimated. Patients with positive axillary lymph nodes have a higher risk of internal lymph nodes metastasis. As a result, IMN-SLNB might be considered in these patients. Future work needs to be done to assess whether pathological confirmed IMN metastasis can affect patients' survival.",
keywords = "Breast Neoplasms, Breast cancer, Internal mammary lymph node, Lymphatic metastasis, Meta-analysis, Sentinel lymph node biopsy, Systematic review",
author = "Jing Gong and Yongfu Yu and Gaosong Wu and Congyao Lin and Xin Tu",
year = "2019",
month = aug,
day = "5",
doi = "10.1186/s12957-019-1683-8",
language = "English",
volume = "17",
journal = "World Journal of Surgical Oncology",
issn = "1477-7819",
publisher = "BioMed Central",
number = "1",

}

RIS

TY - JOUR

T1 - Should internal mammary lymph node sentinel biopsy be performed in breast cancer

T2 - a systematic review and meta-analysis

AU - Gong, Jing

AU - Yu, Yongfu

AU - Wu, Gaosong

AU - Lin, Congyao

AU - Tu, Xin

PY - 2019/8/5

Y1 - 2019/8/5

N2 - PURPOSE: Results from studies of internal mammary lymph node sentinel biopsy are inconsistent.METHODS: A comprehensive literature search was conducted in MEDLINE, EMBASE, Scopus, Cochrane database, and Clinical Trials. Studies reporting the rate of internal mammary lymph node sentinel biopsy (IMN-SLNB) positivity were identified. We performed pooled proportion meta-analysis using random-effects meta-analyses. The correlation of IMN and axillary lymph node (AXN) metastasis was also investigated.RESULTS: After application of inclusion and exclusion criteria, a total of 18 articles (total number of patients = 2427) were included. The pooled estimate for IMN-SLNB positivity rate was 15% (95% confidence interval (CI) 12-17%). Significant between-study heterogeneity was observed. Our results indicate that axillary lymph node metastasis is a strong predictor of IMN involvement (OR 6.01, 95% CI, 3.49, 10.34).CONCLUSION: Internal mammary lymph nodes metastasis might be underestimated. Patients with positive axillary lymph nodes have a higher risk of internal lymph nodes metastasis. As a result, IMN-SLNB might be considered in these patients. Future work needs to be done to assess whether pathological confirmed IMN metastasis can affect patients' survival.

AB - PURPOSE: Results from studies of internal mammary lymph node sentinel biopsy are inconsistent.METHODS: A comprehensive literature search was conducted in MEDLINE, EMBASE, Scopus, Cochrane database, and Clinical Trials. Studies reporting the rate of internal mammary lymph node sentinel biopsy (IMN-SLNB) positivity were identified. We performed pooled proportion meta-analysis using random-effects meta-analyses. The correlation of IMN and axillary lymph node (AXN) metastasis was also investigated.RESULTS: After application of inclusion and exclusion criteria, a total of 18 articles (total number of patients = 2427) were included. The pooled estimate for IMN-SLNB positivity rate was 15% (95% confidence interval (CI) 12-17%). Significant between-study heterogeneity was observed. Our results indicate that axillary lymph node metastasis is a strong predictor of IMN involvement (OR 6.01, 95% CI, 3.49, 10.34).CONCLUSION: Internal mammary lymph nodes metastasis might be underestimated. Patients with positive axillary lymph nodes have a higher risk of internal lymph nodes metastasis. As a result, IMN-SLNB might be considered in these patients. Future work needs to be done to assess whether pathological confirmed IMN metastasis can affect patients' survival.

KW - Breast Neoplasms

KW - Breast cancer

KW - Internal mammary lymph node

KW - Lymphatic metastasis

KW - Meta-analysis

KW - Sentinel lymph node biopsy

KW - Systematic review

U2 - 10.1186/s12957-019-1683-8

DO - 10.1186/s12957-019-1683-8

M3 - Review

C2 - 31382973

VL - 17

JO - World Journal of Surgical Oncology

JF - World Journal of Surgical Oncology

SN - 1477-7819

IS - 1

M1 - 135

ER -