Short- and long-term mortality after deep sternal wound infection following cardiac surgery: experiences from SWEDEHEART

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Short- and long-term mortality after deep sternal wound infection following cardiac surgery : experiences from SWEDEHEART. / Kaspersen, Alexander Emil; Nielsen, Susanne J; Orrason, Andri Wilberg; Petursdottir, Astridur; Sigurdsson, Martin Ingi; Jeppsson, Anders; Gudbjartsson, Tomas.

In: European Journal of Cardio-Thoracic Surgery, Vol. 60, No. 2, 08.2021, p. 233–241.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Kaspersen, AE, Nielsen, SJ, Orrason, AW, Petursdottir, A, Sigurdsson, MI, Jeppsson, A & Gudbjartsson, T 2021, 'Short- and long-term mortality after deep sternal wound infection following cardiac surgery: experiences from SWEDEHEART', European Journal of Cardio-Thoracic Surgery, vol. 60, no. 2, pp. 233–241. https://doi.org/10.1093/ejcts/ezab080

APA

Kaspersen, A. E., Nielsen, S. J., Orrason, A. W., Petursdottir, A., Sigurdsson, M. I., Jeppsson, A., & Gudbjartsson, T. (2021). Short- and long-term mortality after deep sternal wound infection following cardiac surgery: experiences from SWEDEHEART. European Journal of Cardio-Thoracic Surgery, 60(2), 233–241. https://doi.org/10.1093/ejcts/ezab080

CBE

Kaspersen AE, Nielsen SJ, Orrason AW, Petursdottir A, Sigurdsson MI, Jeppsson A, Gudbjartsson T. 2021. Short- and long-term mortality after deep sternal wound infection following cardiac surgery: experiences from SWEDEHEART. European Journal of Cardio-Thoracic Surgery. 60(2):233–241. https://doi.org/10.1093/ejcts/ezab080

MLA

Vancouver

Kaspersen AE, Nielsen SJ, Orrason AW, Petursdottir A, Sigurdsson MI, Jeppsson A et al. Short- and long-term mortality after deep sternal wound infection following cardiac surgery: experiences from SWEDEHEART. European Journal of Cardio-Thoracic Surgery. 2021 Aug;60(2):233–241. https://doi.org/10.1093/ejcts/ezab080

Author

Kaspersen, Alexander Emil ; Nielsen, Susanne J ; Orrason, Andri Wilberg ; Petursdottir, Astridur ; Sigurdsson, Martin Ingi ; Jeppsson, Anders ; Gudbjartsson, Tomas. / Short- and long-term mortality after deep sternal wound infection following cardiac surgery : experiences from SWEDEHEART. In: European Journal of Cardio-Thoracic Surgery. 2021 ; Vol. 60, No. 2. pp. 233–241.

Bibtex

@article{af93218eba81437aa718fe8b958ef8b4,
title = "Short- and long-term mortality after deep sternal wound infection following cardiac surgery: experiences from SWEDEHEART",
abstract = "OBJECTIVES: Deep sternal wound infection (DSWI) is a serious complication after open-heart surgery. We investigated the association between DSWI and short- and long-term all-cause mortality in a large well-defined nationwide population.METHODS: A retrospective, nationwide cohort study, which included 114 676 consecutive patients who underwent coronary artery bypass grafting (CABG) and/or valve surgery from 1997 to 2015 in Sweden. Short- and long-term mortality was compared between DSWI patients and non-DSWI patients using propensity score inverse probability weighting adjustment based on patient characteristics and comorbidities. Median follow-up was 8.0 years (range 0-18.9).RESULTS: Altogether, 1516 patients (1.3%) developed DSWI, most commonly in patients undergoing combined CABG and valve surgery (2.1%). DSWI patients were older and had more disease burden than non-DSWI patients. The unadjusted cumulative mortality was higher in the DSWI group compared with the non-DSWI group at 90 days (7.9% vs 3.0%, P < 0.001) and at 1 year (12.8% vs 4.5%, P < 0.001). The adjusted absolute difference in risk of death was 2.3% [95% confidence interval (CI): 0.8-3.9] at 90 days and 4.7% (95% CI: 2.6-6.7) at 1 year. DSWI was independently associated with 90-day [adjusted relative risk (aRR) 1.89 (95% CI: 1.38-2.59)], 1-year [aRR 2.13 (95% CI: 1.68-2.71)] and long-term all-cause mortality [adjusted hazard ratio 1.56 (95% CI: 1.30-1.88)].CONCLUSIONS: Both short- and long-term mortality risks are higher in DSWI patients compared to non-DSWI patients. These results stress the importance of preventing these infections and careful postoperative monitoring of DSWI patients.",
keywords = "Deep sternal wound infection (DSWI), Mediastinitis, Cardiac surgery, Incidence, Mortality",
author = "Kaspersen, {Alexander Emil} and Nielsen, {Susanne J} and Orrason, {Andri Wilberg} and Astridur Petursdottir and Sigurdsson, {Martin Ingi} and Anders Jeppsson and Tomas Gudbjartsson",
note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.",
year = "2021",
month = aug,
doi = "10.1093/ejcts/ezab080",
language = "English",
volume = "60",
pages = "233–241",
journal = "European Journal of Cardio-Thoracic Surgery",
issn = "1010-7940",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Short- and long-term mortality after deep sternal wound infection following cardiac surgery

T2 - experiences from SWEDEHEART

AU - Kaspersen, Alexander Emil

AU - Nielsen, Susanne J

AU - Orrason, Andri Wilberg

AU - Petursdottir, Astridur

AU - Sigurdsson, Martin Ingi

AU - Jeppsson, Anders

AU - Gudbjartsson, Tomas

N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

PY - 2021/8

Y1 - 2021/8

N2 - OBJECTIVES: Deep sternal wound infection (DSWI) is a serious complication after open-heart surgery. We investigated the association between DSWI and short- and long-term all-cause mortality in a large well-defined nationwide population.METHODS: A retrospective, nationwide cohort study, which included 114 676 consecutive patients who underwent coronary artery bypass grafting (CABG) and/or valve surgery from 1997 to 2015 in Sweden. Short- and long-term mortality was compared between DSWI patients and non-DSWI patients using propensity score inverse probability weighting adjustment based on patient characteristics and comorbidities. Median follow-up was 8.0 years (range 0-18.9).RESULTS: Altogether, 1516 patients (1.3%) developed DSWI, most commonly in patients undergoing combined CABG and valve surgery (2.1%). DSWI patients were older and had more disease burden than non-DSWI patients. The unadjusted cumulative mortality was higher in the DSWI group compared with the non-DSWI group at 90 days (7.9% vs 3.0%, P < 0.001) and at 1 year (12.8% vs 4.5%, P < 0.001). The adjusted absolute difference in risk of death was 2.3% [95% confidence interval (CI): 0.8-3.9] at 90 days and 4.7% (95% CI: 2.6-6.7) at 1 year. DSWI was independently associated with 90-day [adjusted relative risk (aRR) 1.89 (95% CI: 1.38-2.59)], 1-year [aRR 2.13 (95% CI: 1.68-2.71)] and long-term all-cause mortality [adjusted hazard ratio 1.56 (95% CI: 1.30-1.88)].CONCLUSIONS: Both short- and long-term mortality risks are higher in DSWI patients compared to non-DSWI patients. These results stress the importance of preventing these infections and careful postoperative monitoring of DSWI patients.

AB - OBJECTIVES: Deep sternal wound infection (DSWI) is a serious complication after open-heart surgery. We investigated the association between DSWI and short- and long-term all-cause mortality in a large well-defined nationwide population.METHODS: A retrospective, nationwide cohort study, which included 114 676 consecutive patients who underwent coronary artery bypass grafting (CABG) and/or valve surgery from 1997 to 2015 in Sweden. Short- and long-term mortality was compared between DSWI patients and non-DSWI patients using propensity score inverse probability weighting adjustment based on patient characteristics and comorbidities. Median follow-up was 8.0 years (range 0-18.9).RESULTS: Altogether, 1516 patients (1.3%) developed DSWI, most commonly in patients undergoing combined CABG and valve surgery (2.1%). DSWI patients were older and had more disease burden than non-DSWI patients. The unadjusted cumulative mortality was higher in the DSWI group compared with the non-DSWI group at 90 days (7.9% vs 3.0%, P < 0.001) and at 1 year (12.8% vs 4.5%, P < 0.001). The adjusted absolute difference in risk of death was 2.3% [95% confidence interval (CI): 0.8-3.9] at 90 days and 4.7% (95% CI: 2.6-6.7) at 1 year. DSWI was independently associated with 90-day [adjusted relative risk (aRR) 1.89 (95% CI: 1.38-2.59)], 1-year [aRR 2.13 (95% CI: 1.68-2.71)] and long-term all-cause mortality [adjusted hazard ratio 1.56 (95% CI: 1.30-1.88)].CONCLUSIONS: Both short- and long-term mortality risks are higher in DSWI patients compared to non-DSWI patients. These results stress the importance of preventing these infections and careful postoperative monitoring of DSWI patients.

KW - Deep sternal wound infection (DSWI)

KW - Mediastinitis

KW - Cardiac surgery

KW - Incidence

KW - Mortality

U2 - 10.1093/ejcts/ezab080

DO - 10.1093/ejcts/ezab080

M3 - Journal article

C2 - 33623983

VL - 60

SP - 233

EP - 241

JO - European Journal of Cardio-Thoracic Surgery

JF - European Journal of Cardio-Thoracic Surgery

SN - 1010-7940

IS - 2

ER -