Department of Economics and Business Economics

Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Melissa A Munn-Chernoff, Univ North Carolina Chapel Hill, University of North Carolina, University of North Carolina Chapel Hill, University of North Carolina School of Medicine, Dept Phys & Astron
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  • Emma C Johnson, Washington University School of Medicine
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  • Yi-Ling Chou, Washington University School of Medicine
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  • Jonathan R I Coleman, King's College London
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  • Laura M Thornton, Univ North Carolina Chapel Hill, University of North Carolina, University of North Carolina Chapel Hill, University of North Carolina School of Medicine, Dept Phys & Astron
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  • Raymond K Walters, Massachusetts General Hospital and Harvard Medical School
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  • Zeynep Yilmaz
  • Jessica H Baker, Univ North Carolina Chapel Hill, University of North Carolina, University of North Carolina Chapel Hill, University of North Carolina School of Medicine, Dept Phys & Astron
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  • Christopher Hübel
  • Scott Gordon, QIMR Berghofer Medical Research Institute
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  • Sarah E Medland, QIMR Berghofer Medical Research Institute
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  • Hunna J Watson, Univ North Carolina Chapel Hill, University of North Carolina, University of North Carolina Chapel Hill, University of North Carolina School of Medicine, Dept Phys & Astron
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  • Héléna A Gaspar, King's College London
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  • Julien Bryois, Karolinska Institutet
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  • Anke Hinney, University of Duisburg-Essen
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  • Virpi M Leppä, Karolinska Institutet
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  • Manuel Mattheisen, Stockholm County Council, Karolinska Institutet, University of Würzburg
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  • Stephan Ripke, Massachusetts General Hospital and Harvard Medical School
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  • Shuyang Yao, Karolinska Institutet
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  • Paola Giusti-Rodríguez, Univ North Carolina Chapel Hill, University of North Carolina, University of North Carolina Chapel Hill, University of North Carolina School of Medicine, Dept Phys & Astron
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  • Ken B Hanscombe, King's College London
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  • Roger A H Adan, Utrecht University
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  • Lars Alfredsson, Karolinska Institutet
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  • Tetsuya Ando, National Institute of Mental Health, National Institutes of Health
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  • Ole A Andreassen, University of Oslo
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  • Wade H Berrettini, University of Pennsylvania Perelman School of Medicine
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  • Ilka Boehm, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Germany.
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  • Claudette Boni, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
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  • Vesna Boraska Perica, Sanger Inst, Wellcome Trust Sanger Institute
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  • Katharina Buehren, RWTH Univ, RWTH Aachen University, Dept Nephrol
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  • Roland Burghardt, Klinikum Frankfurt/Oder
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  • Matteo Cassina, University of Padova, Padova, Italy
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  • Sven Cichon, Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Department of Biomedicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.
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  • Maurizio Clementi, University of Padova, Padova, Italy
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  • Roger D Cone, University of Michigan, Ann Arbor
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  • Philippe Courtet, Montpellier University, UMR 1183, Montpellier, France
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  • Scott Crow, Univ Minnesota, University of Minnesota Twin Cities, University of Minnesota System, University of Minnesota Duluth, Dept Earth & Environm Sci
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  • James J Crowley, Univ North Carolina Chapel Hill, University of North Carolina, University of North Carolina Chapel Hill, University of North Carolina School of Medicine, Dept Phys & Astron
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  • Unna N Danner, Altrecht Mental Health Institute
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  • Oliver S P Davis, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
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  • Martina de Zwaan, ZTL-Imaging Center, Hannover Medical School, Hannover
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  • George Dedoussis, Harokopio University
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  • Daniela Degortes, University of Padova, Padova, Italy
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  • Janiece E DeSocio, College of Nursing, Seattle University, Seattle, WA, USA.
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  • Danielle M Dick, Virginia Commonwealth Univ, Virginia Commonwealth University, Dept Psychiat
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  • Dimitris Dikeos, Medical Physics Laboratory, Medical School, University of Athens, 75 Mikras Asias, 115 27, Athens, Greece
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  • Christian Dina, L'institut du thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, Nantes, France.
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  • Monika Dmitrzak-Weglarz, Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.
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  • Elisa Docampo, Barcelona Institute of Science and Technology
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  • Laramie E Duncan, Department of Pediatrics, Stanford University, Stanford, CA 94305, USA; Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA; Department of Computer Science, Stanford University, Stanford, CA 94305, USA.
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  • Karin Egberts, Renal Division, University of Würzburg, University Hospital, Wurzburg, Germany.
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  • Stefan Ehrlich, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Germany.
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  • Geòrgia Escaramís, Barcelona Institute of Science and Technology
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  • Tõnu Esko, University of Tartu
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  • Xavier Estivill, Barcelona Institute of Science and Technology
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  • Anne Farmer, King's College London
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  • Angela Favaro, University of Padova, Padova, Italy
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  • Fernando Fernández-Aranda, University Hospital Bellvitge-IDIBELL and CIBEROBN
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  • Manfred M Fichter, Ludwig-Maximilians-University, Munich
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  • Krista Fischer, University of Tartu
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  • Manuel Föcker, University of Münster
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  • Lenka Foretova, Masaryk Memorial Cancer Institute
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  • Andreas J Forstner, Basel Institute for Clinical Epidemiology and Biostatistics, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
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  • Monica Forzan, University of Padova, Padova, Italy
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  • Christopher S Franklin, Sanger Inst, Wellcome Trust Sanger Institute
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  • Steven Gallinger, University of Toronto
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  • Ina Giegling, Martin Luther Univ Halle Wittenberg, Martin Luther University Halle Wittenberg, Inst Biol Geobot & Bot Garden
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  • Johanna Giuranna, University of Duisburg-Essen
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  • Fragiskos Gonidakis, National and Kapodistrian University of Athens
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  • Philip Gorwood, INSERM 1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.
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  • Monica Gratacos Mayora, Barcelona Institute of Science and Technology
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  • Sébastien Guillaume, Montpellier University, UMR 1183, Montpellier, France
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  • Yiran Guo, Center for Applied Genomics, Children's Hospital of Philadelphia, Abramson Research Center, Philadelphia, PA 19104, United States; Beijing Genomics Institute at Shenzhen, Shenzhen 518083, China.
  • ,
  • Hakon Hakonarson, Center for Applied Genomics, Children's Hospital of Philadelphia, Abramson Research Center, Philadelphia, PA 19104, United States; Beijing Genomics Institute at Shenzhen, Shenzhen 518083, China.
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  • Konstantinos Hatzikotoulas, Sanger Inst, Wellcome Trust Sanger Institute
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  • Joanna Hauser, Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.
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  • Johannes Hebebrand, University of Duisburg-Essen
  • ,
  • Sietske G Helder, King's College London
  • ,
  • Stefan Herms, Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Department of Biomedicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.
  • ,
  • Beate Herpertz-Dahlmann, RWTH Univ, RWTH Aachen University, Dept Nephrol
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  • Wolfgang Herzog, Heidelberg Ion Beam Therapy Center (HIT), Heidelberg University Hospital, Heidelberg
  • ,
  • Laura M Huckins, Sanger Inst, Wellcome Trust Sanger Institute
  • ,
  • James I Hudson, McLean Hospital, Harvard Medical School
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  • Hartmut Imgart, Eating Disorders Unit
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  • Hidetoshi Inoko, Tokai Univ, Tokai University, Sch Med, Dept Orthopaed Surg
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  • Vladimir Janout, Palacky Univ, Palacky University Olomouc, Dept Phys Chem
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  • Susana Jiménez-Murcia, University Hospital Bellvitge-IDIBELL and CIBEROBN
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  • Antonio Julià, Vall d'Hebron Research Institute
  • ,
  • Gursharan Kalsi, King's College London
  • ,
  • Deborah Kaminská, Charles Darwin University
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  • Leila Karhunen, Univ Eastern Finland, University of Eastern Finland, Sch Pharm
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  • Andreas Karwautz, Medical University of Vienna
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  • Martien J H Kas, Utrecht University
  • ,
  • James L Kennedy, Centre for Addiction and Mental Health
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  • Anna Keski-Rahkonen, University of Helsinki
  • ,
  • Kirsty Kiezebrink, Aberdeen Biomedial Imaging Centre, University of Aberdeen
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  • Youl-Ri Kim, Inje University
  • ,
  • Kelly L Klump, Michigan State University
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  • Gun Peggy S Knudsen, Norwegian Institute of Public Health
  • ,
  • Maria C La Via, Univ North Carolina Chapel Hill, University of North Carolina, University of North Carolina Chapel Hill, University of North Carolina School of Medicine, Dept Phys & Astron
  • ,
  • Stephanie Le Hellard, Department of Biology, University of Bergen, Bergen, Norway; Sars International Centre, Uni Research, University of Bergen, Bergen, Norway.
  • ,
  • Robert D Levitan, Centre for Addiction and Mental Health
  • ,
  • Dong Li, Center for Applied Genomics, Children's Hospital of Philadelphia, Abramson Research Center, Philadelphia, PA 19104, United States; Beijing Genomics Institute at Shenzhen, Shenzhen 518083, China.
  • ,
  • Lisa Lilenfeld, The Chicago School of Professional Psychology
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  • Bochao Danae Lin, Utrecht University
  • ,
  • Jolanta Lissowska, M Skłodowska-Curie Cancer Center - Oncology Center
  • ,
  • Jurjen Luykx, Utrecht University
  • ,
  • Pierre J Magistretti, King Abdullah University of Science and Technology (KAUST)
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  • Mario Maj, University of Campania Luigi Vanvitelli
  • ,
  • Katrin Mannik, University of Tartu
  • ,
  • Sara Marsal, Vall d'Hebron Research Institute
  • ,
  • Christian R Marshall, The Hospital for Sick Children
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  • Morten Mattingsdal, University of Oslo
  • ,
  • Sara McDevitt, University College Cork
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  • Peter McGuffin, King's College London
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  • Andres Metspalu, University of Tartu
  • ,
  • Ingrid Meulenbelt, Leiden University Medical Centre (LUMC) Leiden
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  • Nadia Micali, Cansearch Research Laboratory, Geneva University Hospital, Geneva University, Geneva, Switzerland.
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  • Karen Mitchell, National Center for PTSD Executive Division
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  • Alessio Maria Monteleone, University of Campania Luigi Vanvitelli
  • ,
  • Palmiero Monteleone, Univ Salerno, University of Salerno, Dipartimento Chim & Biol
  • ,
  • Benedetta Nacmias, University of Florence
  • ,
  • Marie Navratilova, Masaryk Memorial Cancer Institute
  • ,
  • Ioanna Ntalla, Harokopio University
  • ,
  • Julie K O'Toole, Kartini Clinic
  • ,
  • Roel A Ophoff, University of California at Los Angeles
  • ,
  • Leonid Padyukov, Department of Pathology and Cytology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
  • ,
  • Aarno Palotie, Broad Institute of Harvard and MIT
  • ,
  • Jacques Pantel, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • ,
  • Hana Papezova, Charles Darwin University
  • ,
  • Dalila Pinto, Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of
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  • Raquel Rabionet, Saint Joan de Déu Research Institute
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  • Anu Raevuori, University of Helsinki
  • ,
  • Nicolas Ramoz, INSERM 1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.
  • ,
  • Ted Reichborn-Kjennerud, Norwegian Institute of Public Health
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  • Valdo Ricca, University of Florence
  • ,
  • Samuli Ripatti, University of Helsinki
  • ,
  • Franziska Ritschel, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Germany.
  • ,
  • Marion Roberts, King's College London
  • ,
  • Alessandro Rotondo, Pisa Univ, University of Pisa, Dipartimento Med Clin & Sperimentale
  • ,
  • Dan Rujescu, Martin Luther Univ Halle Wittenberg, Martin Luther University Halle Wittenberg, Inst Biol Geobot & Bot Garden
  • ,
  • Filip Rybakowski, Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.
  • ,
  • Paolo Santonastaso, University of Padova, Padova, Italy
  • ,
  • André Scherag, SRH Waldklinikum Gera, University Hospital Jena, Jena
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  • Stephen W Scherer, The Hospital for Sick Children
  • ,
  • Ulrike Schmidt, King's College London
  • ,
  • Nicholas J Schork, J. Craig Venter Institute (JCVI)
  • ,
  • Alexandra Schosser, Medical University of Vienna
  • ,
  • Jochen Seitz, RWTH Univ, RWTH Aachen University, Dept Nephrol
  • ,
  • Lenka Slachtova, Charles Darwin University
  • ,
  • P Eline Slagboom, Leiden University Medical Centre (LUMC) Leiden
  • ,
  • Margarita C T Slof-Op't Landt, Center for Eating Disorders Ursula
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  • Agnieszka Slopien, Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.
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  • Sandro Sorbi, University of Florence
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  • Beata Świątkowska, Nofer Institute of Occupational Medicine
  • ,
  • Jin P Szatkiewicz, Univ North Carolina Chapel Hill, University of North Carolina, University of North Carolina Chapel Hill, University of North Carolina School of Medicine, Dept Phys & Astron
  • ,
  • Ioanna Tachmazidou, Sanger Inst, Wellcome Trust Sanger Institute
  • ,
  • Elena Tenconi, University of Padova, Padova, Italy
  • ,
  • Alfonso Tortorella, Department of Psychiatry, University of Naples SUN, Naples, Italy.
  • ,
  • Federica Tozzi, Department of Psychological and Brain Sciences
  • ,
  • Janet Treasure, King's College London
  • ,
  • Artemis Tsitsika, Univ Athens, University of Athens, Clin Psychol
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  • Marta Tyszkiewicz-Nwafor, Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.
  • ,
  • Konstantinos Tziouvas, Univ Athens, University of Athens, Clin Psychol
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  • Annemarie A van Elburg, Altrecht Mental Health Institute
  • ,
  • Eric F van Furth, Center for Eating Disorders Ursula
  • ,
  • Gudrun Wagner, Medical University of Vienna
  • ,
  • Esther Walton, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Germany.
  • ,
  • Elisabeth Widen, University of Helsinki
  • ,
  • Eleftheria Zeggini, Sanger Inst, Wellcome Trust Sanger Institute
  • ,
  • Stephanie Zerwas, Univ North Carolina Chapel Hill, University of North Carolina, University of North Carolina Chapel Hill, University of North Carolina School of Medicine, Dept Phys & Astron
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  • Stephan Zipfel, University Medical Hospital Tuebingen
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  • Andrew W Bergen, BioRealm LLC
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  • Joseph M Boden, Univ Otago, University of Otago, Relig Programme
  • ,
  • Harry Brandt, The Center for Eating Disorders at Sheppard Pratt, 6501 N. Charles Street, Baltimore, MD 21204, USA.
  • ,
  • Steven Crawford, The Center for Eating Disorders at Sheppard Pratt, 6501 N. Charles Street, Baltimore, MD 21204, USA.
  • ,
  • Katherine A Halmi, Weill Cornell Med Qatar, Weill Cornell Medical College Qatar
  • ,
  • L John Horwood, Univ Otago, University of Otago, Relig Programme
  • ,
  • Craig Johnson, Eating Recovery Center
  • ,
  • Allan S Kaplan, Centre for Addiction and Mental Health
  • ,
  • Walter H Kaye, University of California at San Diego
  • ,
  • James Mitchell, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA.
  • ,
  • Catherine M Olsen, QIMR Berghofer Medical Research Institute
  • ,
  • John F Pearson, Univ Otago, University of Otago, Relig Programme
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  • Nancy L Pedersen, Karolinska Institutet
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  • Michael Strober, University of California at Los Angeles
  • ,
  • Thomas Werge, University of Copenhagen
  • ,
  • David C Whiteman, QIMR Berghofer Medical Research Institute
  • ,
  • D Blake Woodside, University of Toronto
  • ,
  • Jakob Grove
  • Anjali K Henders, Queensland Centre for Mental Health Research, University of Queensland, St. Lucia, Queensland, Australia; Queensland Brain Institute, University of Queensland, St. Lucia, Queensland, Australia; National Centre for Register-based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark.. Electronic address: j.mcgrath@uq.edu.au.
  • ,
  • Janne T Larsen
  • Richard Parker, QIMR Berghofer Medical Research Institute
  • ,
  • Liselotte V Petersen
  • Jennifer Jordan, Univ Otago, University of Otago, Relig Programme
  • ,
  • Martin A Kennedy, Univ Otago, University of Otago, Relig Programme
  • ,
  • Andreas Birgegård, Karolinska Institutet
  • ,
  • Paul Lichtenstein, Karolinska Institutet
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  • Claes Norring, Karolinska Institutet
  • ,
  • Mikael Landén, Karolinska Institutet
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  • Preben Bo Mortensen
  • Renato Polimanti, Yale School of Medicine, Yale University
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  • Jeanette N McClintick, Indiana University School of Medicine, South Bend, Indiana
  • ,
  • Amy E Adkins, Virginia Commonwealth Univ, Virginia Commonwealth University, Dept Psychiat
  • ,
  • Fazil Aliev, Virginia Commonwealth Univ, Virginia Commonwealth University, Dept Psychiat
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  • Silviu-Alin Bacanu, Virginia Commonwealth Univ, Virginia Commonwealth University, Dept Psychiat
  • ,
  • Anthony Batzler, Psychiatric Genomics and Pharmacogenomics Program
  • ,
  • Sarah Bertelsen, Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of
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  • Joanna M Biernacka, Department of Health Sciences Research, Mayo Clinic.
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  • Tim B Bigdeli, State University of New York Downstate Medical Center
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  • Li-Shiun Chen, Washington University School of Medicine
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  • Toni-Kim Clarke, University of Edinburgh
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  • Franziska Degenhardt, University of Bonn
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  • Anna R Docherty, Department of Chemistry, University of Utah, Utah.
  • ,
  • Alexis C Edwards, Virginia Commonwealth Univ, Virginia Commonwealth University, Dept Psychiat
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  • Jerome C Foo, Heidelberg Univ, Ruprecht Karl University Heidelberg, Dept Phys & Astron Heidelberg
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  • Louis Fox, Washington University School of Medicine
  • ,
  • Josef Frank, Heidelberg Univ, Ruprecht Karl University Heidelberg, Dept Phys & Astron Heidelberg
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  • Laura M Hack, Department of Pediatrics, Stanford University, Stanford, CA 94305, USA; Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA; Department of Computer Science, Stanford University, Stanford, CA 94305, USA.
  • ,
  • Annette M Hartmann, Martin Luther Univ Halle Wittenberg, Martin Luther University Halle Wittenberg, Inst Biol Geobot & Bot Garden
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  • Sarah M Hartz, Washington University School of Medicine
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  • Stefanie Heilmann-Heimbach, University of Bonn
  • ,
  • Colin Hodgkinson, Laboratory for Neurogenetics, National Institutes for Health, Bethesda, USA.
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  • Per Hoffmann, Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Department of Biomedicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.
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  • Jouke-Jan Hottenga, Amsterdam Public Health Research Institute
  • ,
  • Bettina Konte, Martin Luther Univ Halle Wittenberg, Martin Luther University Halle Wittenberg, Inst Biol Geobot & Bot Garden
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  • Jari Lahti, University of Turku
  • ,
  • Marius Lahti-Pulkkinen, University of Helsinki
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  • Dongbing Lai, Indiana University School of Medicine, South Bend, Indiana
  • ,
  • Lannie Ligthart, Amsterdam Public Health Research Institute
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  • Anu Loukola, University of Helsinki
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  • Brion S Maher, Johns Hopkins Bloomberg School of Public Health
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  • Hamdi Mbarek, Amsterdam Public Health Research Institute
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  • Andrew M McIntosh, University of Edinburgh
  • ,
  • Matthew B McQueen, Univ Boulder Colorado, University of Colorado Boulder, University of Colorado System, Inst Arct & Alpine Res INSTAAR
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  • Jacquelyn L Meyers, SUNY-Downstate Medical Center,
  • Yuri Milaneschi, Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam, The Netherlands.
  • ,
  • Teemu Palviainen, University of Helsinki
  • ,
  • Roseann E Peterson, Virginia Commonwealth Univ, Virginia Commonwealth University, Dept Psychiat
  • ,
  • Euijung Ryu, Department of Health Sciences Research, Mayo Clinic.
  • ,
  • Nancy L Saccone, Washington University School of Medicine
  • ,
  • Jessica E Salvatore, Virginia Commonwealth Univ, Virginia Commonwealth University, Dept Psychiat
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  • Sandra Sanchez-Roige, University of California at San Diego
  • ,
  • Melanie Schwandt, Office of the Clinical Director , National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland.
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  • Richard Sherva, Boston University School of Medicine, Boston, MA
  • ,
  • Fabian Streit, Heidelberg Univ, Ruprecht Karl University Heidelberg, Dept Phys & Astron Heidelberg
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  • Jana Strohmaier, Heidelberg Univ, Ruprecht Karl University Heidelberg, Dept Phys & Astron Heidelberg
  • ,
  • Nathaniel Thomas, Virginia Commonwealth Univ, Virginia Commonwealth University, Dept Psychiat
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  • Jen-Chyong Wang, Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of
  • ,
  • Bradley T Webb, Virginia Commonwealth Univ, Virginia Commonwealth University, Dept Psychiat
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  • Robbee Wedow, Massachusetts General Hospital and Harvard Medical School
  • ,
  • Leah Wetherill, Indiana University School of Medicine, South Bend, Indiana
  • ,
  • Amanda G Wills, University of Colorado School of Medicine
  • ,
  • Hang Zhou, Yale School of Medicine, Yale University
  • ,
  • Jason D Boardman, Univ Colorado, University of Colorado System, University of Colorado Denver, University of Colorado Health Science Center, Dept Med
  • ,
  • Danfeng Chen, Broad Institute of Harvard and MIT
  • ,
  • Doo-Sup Choi, Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN
  • ,
  • William E Copeland, Univ Vermont, University of Vermont, University of Vermont Medical Center, Dept Med, Med Ctr
  • ,
  • Robert C Culverhouse, Washington University School of Medicine
  • ,
  • Norbert Dahmen, University Medical Centre Mainz, Mainz, Germany
  • ,
  • Louisa Degenhardt, Kirby Institute, University of New South Wales Medicine, University of New South Wales
  • ,
  • Benjamin W Domingue, University of California at San Diego
  • ,
  • Mark A Frye, Department of Psychiatry and Clinical Psychology, Faculty of Medicine, Balamand University Department of Psychiatry and Clinical Psychology, St. George Hospital University Medical Center, Beirut, Lebanon.
  • ,
  • Wolfgang Gäebel, Heinrich Heine Univ Dusseldorf, Heinrich Heine University Dusseldorf, Heinrich Heine University Dusseldorf Hospital, Univ Hosp Dusseldorf, Dept Gynaecol & Obstet
  • ,
  • Caroline Hayward, University of Edinburgh
  • ,
  • Marcus Ising, Max Planck Institute of Psychiatry
  • ,
  • Margaret Keyes, Univ Minnesota, University of Minnesota Twin Cities, University of Minnesota System, University of Minnesota Duluth, Dept Earth & Environm Sci
  • ,
  • Falk Kiefer, Heidelberg Univ, Ruprecht Karl University Heidelberg, Dept Phys & Astron Heidelberg
  • ,
  • Gabriele Koller, Univ Munich, University of Munich
  • ,
  • John Kramer, University of Iowa Roy J and Lucille A Carver College of Medicine
  • ,
  • Samuel Kuperman, University of Iowa Roy J and Lucille A Carver College of Medicine
  • ,
  • Susanne Lucae, Max Planck Institute of Psychiatry
  • ,
  • Michael T Lynskey, King's College London
  • ,
  • Wolfgang Maier, University of Bonn
  • ,
  • Karl Mann, Heidelberg Univ, Ruprecht Karl University Heidelberg, Dept Phys & Astron Heidelberg
  • ,
  • Satu Männistö, National Institute for Health and Welfare
  • ,
  • Bertram Müller-Myhsok, Max Planck Institute of Psychiatry
  • ,
  • Alison D Murray, Aberdeen Biomedial Imaging Centre, University of Aberdeen
  • ,
  • John I Nurnberger, Indiana University School of Medicine, South Bend, Indiana
  • ,
  • Ulrich Preuss, Martin Luther Univ Halle Wittenberg, Martin Luther University Halle Wittenberg, Inst Biol Geobot & Bot Garden
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  • Katri Räikkönen, University of Helsinki
  • ,
  • Maureen D Reynolds, University of Pittsburgh School of Med., Pittsburgh
  • ,
  • Monika Ridinger, University of Regensburg
  • ,
  • Norbert Scherbaum, Univ Duisburg Essen, University of Duisburg Essen, Fak Phys & Cenide
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  • Marc A Schuckit, University of California at San Diego
  • ,
  • Michael Soyka, Ludwig-Maximilians-University, Munich
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Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = −0.19 to −0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.

Original languageEnglish
Article numbere12880
JournalAddiction Biology
Volume26
Issue1
Number of pages20
ISSN1355-6215
DOIs
Publication statusPublished - Jan 2021

    Research areas

  • Alcoholism/genetics, Depressive Disorder, Major/genetics, Feeding and Eating Disorders/genetics, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Phenotype, Polymorphism, Single Nucleotide, Risk Factors, Schizophrenia/genetics, Substance-Related Disorders/genetics, Tobacco Use Disorder/genetics

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