Shared genetic background between children and adults with attention deficit/hyperactivity disorder

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Paula Rovira, Autonomous University of Barcelona, Vall d'Hebron University Hospital
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  • Ditte Demontis
  • Cristina Sánchez-Mora, Autonomous University of Barcelona, Vall d'Hebron University Hospital, Instituto de Salud Carlos III, Universitat Autònoma Barcelona
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  • Tetyana Zayats, University of Bergen, Massachusetts General Hospital, Boston, Broad Institute
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  • Marieke Klein, Radboud University Nijmegen Medical Centre, Utrecht University
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  • Nina Roth Mota, Radboud University Nijmegen Medical Centre, Universidade Federal do Rio Grande do Sul
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  • Heike Weber, University of Würzburg, Goethe University Frankfurt
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  • Iris Garcia-Martínez, Autonomous University of Barcelona, Vall d'Hebron University Hospital, Banc de Sang I Teixits
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  • Mireia Pagerols, Autonomous University of Barcelona, Vall d'Hebron University Hospital
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  • Laura Vilar-Ribó, Psychiatric Genetics Unit, Autonomous University of Barcelona, Vall d'Hebron University Hospital
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  • Lorena Arribas, Autonomous University of Barcelona, Vall d'Hebron University Hospital
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  • Vanesa Richarte, Vall d'Hebron University Hospital, Instituto de Salud Carlos III, Autonomous University of Barcelona
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  • Montserrat Corrales, Vall d'Hebron University Hospital, Instituto de Salud Carlos III, Autonomous University of Barcelona
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  • Christian Fadeuilhe, Vall d'Hebron University Hospital, Instituto de Salud Carlos III, Autonomous University of Barcelona
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  • Rosa Bosch, Vall d'Hebron University Hospital, Instituto de Salud Carlos III, Autonomous University of Barcelona
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  • Gemma Español Martin, Vall d'Hebron University Hospital, Autonomous University of Barcelona, Vall d'Hebron Research Institute
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  • Peter Almos, University of Würzburg
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  • Alysa E. Doyle, Massachusetts General Hospital, Boston, Harvard Medical School
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  • Eugenio Horacio Grevet, Universidade Federal do Rio Grande do Sul
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  • Oliver Grimm, Goethe University Frankfurt
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  • Anne Halmøy, University of Bergen, Department of Occupational Medicine, Haukeland University Hospital, NO-5021 Bergen, Norway. tor.aasen@helse-bergen.no.
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  • Martine Hoogman, Radboud University Nijmegen Medical Centre
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  • Mara Hutz, Universidade Federal do Rio Grande do Sul
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  • Christian P. Jacob, University of Würzburg
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  • Sarah Kittel-Schneider, Goethe University Frankfurt
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  • Per M. Knappskog, Department of Occupational Medicine, Haukeland University Hospital, NO-5021 Bergen, Norway. tor.aasen@helse-bergen.no., University of Bergen
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  • Astri J. Lundervold, University of Bergen
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  • Olga Rivero, University of Würzburg
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  • Diego Luiz Rovaris, Universidade Federal do Rio Grande do Sul, Universidade de São Paulo – USP
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  • Angelica Salatino-Oliveira, Universidade Federal do Rio Grande do Sul
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  • Bruna Santos da Silva, Universidade Federal do Rio Grande do Sul
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  • Evgeniy Svirin, University of Würzburg, I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovskiy University)
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  • Emma Sprooten, Radboud University Nijmegen Medical Centre
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  • Tatyana Strekalova, University of Würzburg, I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovskiy University), Maastricht University
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  • Alejandro Arias-Vasquez, Radboud University Nijmegen Medical Centre
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  • Edmund J.S. Sonuga-Barke, King's College London
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  • Philip Asherson, King's College London
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  • Claiton Henrique Dotto Bau, Universidade Federal do Rio Grande do Sul
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  • Jan K. Buitelaar, Radboud University Nijmegen Medical Centre, Karakter Child and Adolescent Psychiatry
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  • Bru Cormand, Universitat Autònoma Barcelona, CIBER - Center for Biomedical Research Network, Institut de Recerca Sant Joan de Déu
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  • Stephen V. Faraone, State University of New York Upstate Medical University
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  • Jan Haavik, University of Bergen, Department of Occupational Medicine, Haukeland University Hospital, NO-5021 Bergen, Norway. tor.aasen@helse-bergen.no.
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  • Stefan E. Johansson, Department of Occupational Medicine, Haukeland University Hospital, NO-5021 Bergen, Norway. tor.aasen@helse-bergen.no., University of Bergen
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  • Jonna Kuntsi, King's College London
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  • Henrik Larsson, School of Medical Sciences, Örebro University, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Karolinska Institutet
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  • Klaus Peter Lesch, University of Würzburg, I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovskiy University), Maastricht University
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  • Andreas Reif, Goethe University Frankfurt
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  • Luis Augusto Rohde, Universidade Federal do Rio Grande do Sul
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  • Miquel Casas, Autonomous University of Barcelona, Vall d'Hebron University Hospital, Instituto de Salud Carlos III
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  • Anders D. Børglum
  • ADHD Working Group of the Psychiatric Genomics Consortium
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  • 23andMe Research Team

Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. Despite several risk factors during childhood predicting the persistence of ADHD symptoms into adulthood, the genetic architecture underlying the trajectory of ADHD over time is still unclear. We set out to study the contribution of common genetic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide association studies on persistent ADHD in adults and ADHD in childhood separately and jointly, and by comparing the genetic background between them in a total sample of 17,149 cases and 32,411 controls. Our results show nine new independent loci and support a shared contribution of common genetic variants to ADHD in children and adults. No subgroup heterogeneity was observed among children, while this group consists of future remitting and persistent individuals. We report similar patterns of genetic correlation of ADHD with other ADHD-related datasets and different traits and disorders among adults, children, and when combining both groups. These findings confirm that persistent ADHD in adults is a neurodevelopmental disorder and extend the existing hypothesis of a shared genetic architecture underlying ADHD and different traits to a lifespan perspective.

Original languageEnglish
JournalNeuropsychopharmacology
Volume45
Issue10
Pages (from-to)1617-1626
Number of pages10
ISSN0893-133X
DOIs
Publication statusPublished - Sep 2020

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