Sex differences in peripheral not central immune responses to pain-inducing injury

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DOI

  • Douglas M. Lopes, Kings Coll London, Kings College London, University of London, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci
  • ,
  • Natalia Malek, Polish Acad Sci, Polish Academy of Sciences, Inst Pharmacol, Lab Pain Pharmacol
  • ,
  • Michelle Edye, Kings Coll London, Kings College London, University of London, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci
  • ,
  • Sara Buskbjerg Jager
  • Sheridan McMurray, Kings Coll London, Kings College London, University of London, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci
  • ,
  • Stephen B. McMahon, Kings Coll London, Kings College London, University of London, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci
  • ,
  • Franziska Denk, Kings Coll London, Kings College London, University of London, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci

Women suffer chronic pain more frequently than men. It is not clear whether this is due to differences in higher level cognitive processes or basic nociceptive responses. In this study we used a mouse model of neuropathic pain to dissociate these factors. We performed RNA-seq on purified peripheral afferent neurons, but found no striking differences in gene expression between male and female mice, neither before nor after nerve injury. Similarly, spinal cord immune responses between the sexes appeared to be indistinguishable when studied by flow cytometry or qRT-PCR. Differences emerged only upon studying peripheral immune cell infiltration into the dorsal root ganglion, suggesting that adaptive immune responses in neuropathic pain could be sexually dimorphic.

Original languageEnglish
Article number16460
JournalScientific Reports
Volume7
Number of pages8
ISSN2045-2322
DOIs
Publication statusPublished - 28 Nov 2017

    Research areas

  • FEMALE MICE, HYPERSENSITIVITY, MICROGLIA

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