TY - JOUR
T1 - Sex differences in brain regional homogeneity during acute abstinence in cocaine use disorder
AU - Sanvicente-Vieira, Breno
AU - Rothmann, Leonardo Melo
AU - Esper, Nathalia Bianchini
AU - Tondo, Lucca Pizzato
AU - Ferreira, Pedro Eugênio
AU - Buchweitz, Augusto
AU - Franco, Alexandre Rosa
AU - Grassi-Oliveira, Rodrigo
N1 - Funding Information:
This study was supported by NIDA and Fogarty Foundation (RGO) R01DA044859, Secretaria Nacional de Cuidados e Prevenção às Drogas: 822647/2015 and by CNPq (RGO) 466802/2014‐5.
Funding Information:
This study was supported by NIDA and Fogarty Foundation (RGO) R01DA044859, Secretaria Nacional de Cuidados e Preven??o ?s Drogas: 822647/2015 and by CNPq (RGO) 466802/2014-5.
Publisher Copyright:
© 2022 The Authors. Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.
PY - 2022/5
Y1 - 2022/5
N2 - There are significant sex differences in the clinical characteristics of cocaine use disorder (CUD). As this is a brain disorder that involves changes in functional connectivity, we investigated the existence of sex differences among people with CUD and controls. We used a data-driven method comparing males (n = 20, CK-M) and females with CUD (n = 20, CK-F) and healthy controls (20 males, HC-M and 20 females, HC-F). The participants undertook a resting-state functional magnetic resonance imaging exam. Regional homogeneity (ReHo) was performed to identify group and sex differences. Persons with CUD of both sexes presented lower ReHo parameters than controls, especially within the parietal lobule. Males with CUD showed higher ReHo than females in three right-side brain areas: postcentral gyrus, putamen and fusiform gyrus. It was found that abstinence symptoms severity was associated with lower ReHo values in the right postcentral gyrus and the right fusiform gyrus. Participants with CUD exhibited altered ReHo parameters compared to controls, similar to what is found in ageing-related disorders. Our data also indicate that cocaine has sex-specific effects on brain functioning when analysing ReHo.
AB - There are significant sex differences in the clinical characteristics of cocaine use disorder (CUD). As this is a brain disorder that involves changes in functional connectivity, we investigated the existence of sex differences among people with CUD and controls. We used a data-driven method comparing males (n = 20, CK-M) and females with CUD (n = 20, CK-F) and healthy controls (20 males, HC-M and 20 females, HC-F). The participants undertook a resting-state functional magnetic resonance imaging exam. Regional homogeneity (ReHo) was performed to identify group and sex differences. Persons with CUD of both sexes presented lower ReHo parameters than controls, especially within the parietal lobule. Males with CUD showed higher ReHo than females in three right-side brain areas: postcentral gyrus, putamen and fusiform gyrus. It was found that abstinence symptoms severity was associated with lower ReHo values in the right postcentral gyrus and the right fusiform gyrus. Participants with CUD exhibited altered ReHo parameters compared to controls, similar to what is found in ageing-related disorders. Our data also indicate that cocaine has sex-specific effects on brain functioning when analysing ReHo.
KW - cocaine sex differences
KW - resting-state
KW - substance use and related disorders
UR - http://www.scopus.com/inward/record.url?scp=85128807211&partnerID=8YFLogxK
U2 - 10.1111/adb.13177
DO - 10.1111/adb.13177
M3 - Journal article
C2 - 35470550
AN - SCOPUS:85128807211
SN - 1355-6215
VL - 27
JO - Addiction Biology
JF - Addiction Biology
IS - 3
M1 - e13177
ER -