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Severe or critical hypotension during post cardiac arrest care is associated with factors available on admission - a post hoc analysis of the TTH48 trial

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Standard

Severe or critical hypotension during post cardiac arrest care is associated with factors available on admission - a post hoc analysis of the TTH48 trial. / Hästbacka, Johanna; Kirkegaard, Hans; Søreide, Eldar et al.

In: Journal of Critical Care, Vol. 61, 02.2021, p. 186-190.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Harvard

Hästbacka, J, Kirkegaard, H, Søreide, E, Taccone, FS, Rasmussen, BS, Storm, C, Kjaergaard, J, Laitio, T, Duez, CHV, Jeppesen, AN, Grejs, AM & Skrifvars, MB 2021, 'Severe or critical hypotension during post cardiac arrest care is associated with factors available on admission - a post hoc analysis of the TTH48 trial', Journal of Critical Care, vol. 61, pp. 186-190. https://doi.org/10.1016/j.jcrc.2020.10.026

APA

Hästbacka, J., Kirkegaard, H., Søreide, E., Taccone, F. S., Rasmussen, B. S., Storm, C., Kjaergaard, J., Laitio, T., Duez, C. H. V., Jeppesen, A. N., Grejs, A. M., & Skrifvars, M. B. (2021). Severe or critical hypotension during post cardiac arrest care is associated with factors available on admission - a post hoc analysis of the TTH48 trial. Journal of Critical Care, 61, 186-190. https://doi.org/10.1016/j.jcrc.2020.10.026

CBE

Hästbacka J, Kirkegaard H, Søreide E, Taccone FS, Rasmussen BS, Storm C, Kjaergaard J, Laitio T, Duez CHV, Jeppesen AN, et al. 2021. Severe or critical hypotension during post cardiac arrest care is associated with factors available on admission - a post hoc analysis of the TTH48 trial. Journal of Critical Care. 61:186-190. https://doi.org/10.1016/j.jcrc.2020.10.026

MLA

Hästbacka, Johanna et al. "Severe or critical hypotension during post cardiac arrest care is associated with factors available on admission - a post hoc analysis of the TTH48 trial". Journal of Critical Care. 2021, 61. 186-190. https://doi.org/10.1016/j.jcrc.2020.10.026

Vancouver

Hästbacka J, Kirkegaard H, Søreide E, Taccone FS, Rasmussen BS, Storm C et al. Severe or critical hypotension during post cardiac arrest care is associated with factors available on admission - a post hoc analysis of the TTH48 trial. Journal of Critical Care. 2021 Feb;61:186-190. doi: 10.1016/j.jcrc.2020.10.026

Author

Hästbacka, Johanna ; Kirkegaard, Hans ; Søreide, Eldar et al. / Severe or critical hypotension during post cardiac arrest care is associated with factors available on admission - a post hoc analysis of the TTH48 trial. In: Journal of Critical Care. 2021 ; Vol. 61. pp. 186-190.

Bibtex

@article{df7597b6106147b29e44472fe0d91b7c,
title = "Severe or critical hypotension during post cardiac arrest care is associated with factors available on admission - a post hoc analysis of the TTH48 trial",
abstract = "Purpose: We explored whether severe or critical hypotension can be predicted, based on patient and resuscitation characteristics in out-of-hospital cardiac arrest (OHCA) patients. We also explored the association of hypotension with mortality and neurological outcome. Materials and methods: We conducted a post hoc analysis of the TTH48 study (NCT01689077), where 355 out-of-hospital cardiac arrest (OHCA) patients were randomized to targeted temperature management (TTM) treatment at 33 °C for either 24 or 48 h. We recorded hypotension, according to four severity categories, within four days from admission. We used multivariable logistic regression analysis to test association of admission data with severe or critical hypotension. Results: Diabetes mellitus (OR 3.715, 95% CI 1.180–11.692), longer ROSC delay (OR 1.064, 95% CI 1.022–1.108), admission MAP (OR 0.960, 95% CI 0.929–0.991) and non-shockable rhythm (OR 5.307, 95% CI 1.604–17.557) were associated with severe or critical hypotension. Severe or critical hypotension was associated with increased mortality and poor neurological outcome at 6 months. Conclusions: Diabetes, non-shockable rhythm, longer delay to ROSC and lower admission MAP were predictors of severe or critical hypotension. Severe or critical hypotension was associated with poor outcome.",
keywords = "Hemodynamics, Hypotension, Out-of-hospital cardiac arrest, Outcome, Predicting, Targeted temperature management",
author = "Johanna H{\"a}stbacka and Hans Kirkegaard and Eldar S{\o}reide and Taccone, {Fabio Silvio} and Rasmussen, {Bodil Steen} and Christian Storm and Jesper Kjaergaard and Timo Laitio and Duez, {Christophe Henri Valdemar} and Jeppesen, {Anni N.} and Grejs, {Anders M.} and Skrifvars, {Markus B.}",
note = "Funding Information: This work was supported by Finska L{\"a}kares{\"a}llskapet and Stiftelsen Dorothea Olivia, Karl Walter och Jarl Walter Perkl{\'e}ns minne . Publisher Copyright: {\textcopyright} 2020 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = feb,
doi = "10.1016/j.jcrc.2020.10.026",
language = "English",
volume = "61",
pages = "186--190",
journal = "Journal of Critical Care",
issn = "0883-9441",
publisher = "W.B. Saunders Co.",

}

RIS

TY - JOUR

T1 - Severe or critical hypotension during post cardiac arrest care is associated with factors available on admission - a post hoc analysis of the TTH48 trial

AU - Hästbacka, Johanna

AU - Kirkegaard, Hans

AU - Søreide, Eldar

AU - Taccone, Fabio Silvio

AU - Rasmussen, Bodil Steen

AU - Storm, Christian

AU - Kjaergaard, Jesper

AU - Laitio, Timo

AU - Duez, Christophe Henri Valdemar

AU - Jeppesen, Anni N.

AU - Grejs, Anders M.

AU - Skrifvars, Markus B.

N1 - Funding Information: This work was supported by Finska Läkaresällskapet and Stiftelsen Dorothea Olivia, Karl Walter och Jarl Walter Perkléns minne . Publisher Copyright: © 2020 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/2

Y1 - 2021/2

N2 - Purpose: We explored whether severe or critical hypotension can be predicted, based on patient and resuscitation characteristics in out-of-hospital cardiac arrest (OHCA) patients. We also explored the association of hypotension with mortality and neurological outcome. Materials and methods: We conducted a post hoc analysis of the TTH48 study (NCT01689077), where 355 out-of-hospital cardiac arrest (OHCA) patients were randomized to targeted temperature management (TTM) treatment at 33 °C for either 24 or 48 h. We recorded hypotension, according to four severity categories, within four days from admission. We used multivariable logistic regression analysis to test association of admission data with severe or critical hypotension. Results: Diabetes mellitus (OR 3.715, 95% CI 1.180–11.692), longer ROSC delay (OR 1.064, 95% CI 1.022–1.108), admission MAP (OR 0.960, 95% CI 0.929–0.991) and non-shockable rhythm (OR 5.307, 95% CI 1.604–17.557) were associated with severe or critical hypotension. Severe or critical hypotension was associated with increased mortality and poor neurological outcome at 6 months. Conclusions: Diabetes, non-shockable rhythm, longer delay to ROSC and lower admission MAP were predictors of severe or critical hypotension. Severe or critical hypotension was associated with poor outcome.

AB - Purpose: We explored whether severe or critical hypotension can be predicted, based on patient and resuscitation characteristics in out-of-hospital cardiac arrest (OHCA) patients. We also explored the association of hypotension with mortality and neurological outcome. Materials and methods: We conducted a post hoc analysis of the TTH48 study (NCT01689077), where 355 out-of-hospital cardiac arrest (OHCA) patients were randomized to targeted temperature management (TTM) treatment at 33 °C for either 24 or 48 h. We recorded hypotension, according to four severity categories, within four days from admission. We used multivariable logistic regression analysis to test association of admission data with severe or critical hypotension. Results: Diabetes mellitus (OR 3.715, 95% CI 1.180–11.692), longer ROSC delay (OR 1.064, 95% CI 1.022–1.108), admission MAP (OR 0.960, 95% CI 0.929–0.991) and non-shockable rhythm (OR 5.307, 95% CI 1.604–17.557) were associated with severe or critical hypotension. Severe or critical hypotension was associated with increased mortality and poor neurological outcome at 6 months. Conclusions: Diabetes, non-shockable rhythm, longer delay to ROSC and lower admission MAP were predictors of severe or critical hypotension. Severe or critical hypotension was associated with poor outcome.

KW - Hemodynamics

KW - Hypotension

KW - Out-of-hospital cardiac arrest

KW - Outcome

KW - Predicting

KW - Targeted temperature management

UR - http://www.scopus.com/inward/record.url?scp=85095728447&partnerID=8YFLogxK

U2 - 10.1016/j.jcrc.2020.10.026

DO - 10.1016/j.jcrc.2020.10.026

M3 - Journal article

C2 - 33181415

AN - SCOPUS:85095728447

VL - 61

SP - 186

EP - 190

JO - Journal of Critical Care

JF - Journal of Critical Care

SN - 0883-9441

ER -