Serum mannan-binding lectin-associated serine protease 2 levels in colorectal cancer: relation to recurrence and mortality

Henriette Ytting, Ib Jarle Christensen, Steffen Thiel, Jens Christian Jensenius, Hans Jørgen Nielsen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

Mannan-binding lectin-associated serine protease 2 (MASP-2) is a plasma protein involved in inflammatory processes. MASP-2 circulates in complex with the protein mannan-binding lectin (MBL) or ficolins, and is activated to recruit the complement system when MBL binds to its targets. The level of MASP-2 is genetically determined, and the aim of the present study was to evaluate the effect of MASP-2 levels on postoperative infection, recurrence and survival.
Original languageEnglish
JournalClinical Cancer Research
Volume11
Issue4
Pages (from-to)1441-6
Number of pages6
ISSN1078-0432
DOIs
Publication statusPublished - 2005

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Colorectal Neoplasms
  • Female
  • Follow-Up Studies
  • Humans
  • Infection
  • Male
  • Mannose-Binding Protein-Associated Serine Proteases
  • Middle Aged
  • Multivariate Analysis
  • Neoplasm Recurrence, Local
  • Neoplasm Staging
  • Postoperative Complications
  • Serine Endopeptidases
  • Survival Analysis
  • Survival Rate
  • Time Factors

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