Abstract
Objectives: Glial fibrillary acidic protein (GFAP) in blood is an emerging biomarker of brain injury and neurological disease. Its clinical use in children is limited by the lack of a reference interval (RI). Thus, the aim of the present study was to establish an age-dependent continuous RI for serum GFAP in children. Methods: Excess serum from routine allergy testing of 391 children, 0.4-17.9 years of age, was measured by a single-molecule array (Simoa) assay. A continuous RI was modelled using non-parametric quantile regression and presented both graphically and tabulated as discrete one-year RIs based on point estimates from the model. Results: Serum GFAP showed a strong age-dependency with declining levels and variability from infants to adolescents. The estimated median level decreased 66% from four months to five years of age and another 65% from five years to 17.9 years of age. No gender difference was observed. Conclusions: The study establishes an age-dependent RI for serum GFAP in children showing high levels and variability in the first years of life.
| Original language | English |
|---|---|
| Journal | Clinical Chemistry and Laboratory Medicine |
| Volume | 61 |
| Issue | 11 |
| Pages (from-to) | 2041-2045 |
| Number of pages | 5 |
| ISSN | 1434-6621 |
| DOIs | |
| Publication status | Published - Oct 2023 |
Keywords
- children
- glial fibrillary acidic protein (GFAP)
- reference interval
- serum
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