Serie: Medicamenten en mondzorg. Systematisch literatuuronderzoek naar effect van medicatie op de speekselklieren

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleCommunication

  • Andy Wolff, Israel
  • Revan Kumar Joshi, India
  • Jörgen Ekström, Sweden
  • Doron Aframian, Israel
  • Anne Marie Lynge Pedersen, University of Copenhagen, Denmark
  • Gordon Proctor, United Kingdom
  • Nagamani Narayana, United States
  • Alessandro Villa, United States
  • Ying Wai Sia, Canada
  • Ardita Aliko, Albania
  • Richard McGowan, United States
  • Alexander Ross Kerr, United States
  • Siri Beier Jensen
  • Arjan Vissink, Netherlands
  • Colin Dawes, Canada
Evidence-based reviews of drugs causing medication-induced salivary gland dysfunction, such as xerostomia (sensation of oral dryness) and subjective sialorrhea are lacking. To compile a list of medicaments that influence salivary gland function, electronic databases were searched for relevant articles published up to June 2013. A total of 269 papers out of 3,867 records located satisfied the inclusion criteria (relevance, quality of methodology, strength of evidence). A total of 56 active substances with a higher level of evidence and 50 active substances with a moderate level of evidence of causing salivary gland dysfunction are described in this article. While xerostomia was a commonly reported outcome, the objective effect on salivary secretion was rarely measured. Xerostomia was, moreover, mostly reported as a negative side effect instead of the intended effect of that drug. A comprehensive list of medications having documented effects on salivary gland function or symptoms was compiled, which may assist practitioners in assessing patients who complain of dry mouth while taking medications.
Original languageDutch
JournalNederlands Tijdschrift voor Tandheelkunde
Volume125
Pages (from-to)593-601
Number of pages9
ISSN0028-2200
DOIs
Publication statusPublished - 2018

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