TY - JOUR
T1 - Sequelae and post-thrombotic syndrome after venous thromboembolism in acute lymphoblastic leukemia survivors treated on the NOPHO ALL2008 protocol
AU - Dam, Merete
AU - Lynggaard, Line Stensig
AU - Jónsson, Ólafur G.
AU - Saulyte Trakymiene, Sonata
AU - Palk, Katrin
AU - Jarvis, Kirsten
AU - Andrés-Jensen, Liv
AU - Tuckuviene, Ruta
AU - Albertsen, Birgitte Klug
N1 - Publisher Copyright:
© 2024 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.
PY - 2024/6
Y1 - 2024/6
N2 - The treatment of acute lymphoblastic leukemia (ALL) is frequently complicated by toxicity, including venous thromboembolism (VTE) affecting roughly 8% of patients. VTE can lead to post-thrombotic syndrome (PTS), a group of signs and symptoms developed as a complication to deep venous thrombosis (DVT), imposing risk of permanent disability and reduced quality of life (QoL). PTS prevalence ranges from 0% to 70%, reflecting very heterogenous cohorts and assessment tools. We aimed to estimate sequelae, including PTS and QoL in children and adults (<45 years old) who had a DVT during ALL treatment. PTS and QoL scores were obtained through use of Villalta and Modified Villalta Scale, PedsQL, and Short Form-36 questionnaires. The cohort comprised 20 children (<18 years) and seven adults (median age: 12.9 years, range: 2–44 years) at the time of DVT diagnosis. In total, 25 ALL survivors underwent PTS examination. The examination took place when survivors were 7–48 years (median age: 20.3 years, median follow-up time 6.8 years). QoL was assessed correlating cases with three matching ALL survivors without VTE. Two adults (15.4%) showed mild or moderate PTS. Eight children (66.7%) were diagnosed with mild PTS, while three cases had collaterals as sole symptoms. Pain or symptoms affecting daily life were reported by 16%. No difference in QoL was found (p =.9). This study underscores the need for comprehensive population-based investigations with validation of PTS instruments in ALL survivors.
AB - The treatment of acute lymphoblastic leukemia (ALL) is frequently complicated by toxicity, including venous thromboembolism (VTE) affecting roughly 8% of patients. VTE can lead to post-thrombotic syndrome (PTS), a group of signs and symptoms developed as a complication to deep venous thrombosis (DVT), imposing risk of permanent disability and reduced quality of life (QoL). PTS prevalence ranges from 0% to 70%, reflecting very heterogenous cohorts and assessment tools. We aimed to estimate sequelae, including PTS and QoL in children and adults (<45 years old) who had a DVT during ALL treatment. PTS and QoL scores were obtained through use of Villalta and Modified Villalta Scale, PedsQL, and Short Form-36 questionnaires. The cohort comprised 20 children (<18 years) and seven adults (median age: 12.9 years, range: 2–44 years) at the time of DVT diagnosis. In total, 25 ALL survivors underwent PTS examination. The examination took place when survivors were 7–48 years (median age: 20.3 years, median follow-up time 6.8 years). QoL was assessed correlating cases with three matching ALL survivors without VTE. Two adults (15.4%) showed mild or moderate PTS. Eight children (66.7%) were diagnosed with mild PTS, while three cases had collaterals as sole symptoms. Pain or symptoms affecting daily life were reported by 16%. No difference in QoL was found (p =.9). This study underscores the need for comprehensive population-based investigations with validation of PTS instruments in ALL survivors.
UR - http://www.scopus.com/inward/record.url?scp=85187519052&partnerID=8YFLogxK
U2 - 10.1002/pbc.30937
DO - 10.1002/pbc.30937
M3 - Journal article
C2 - 38480517
AN - SCOPUS:85187519052
SN - 1545-5009
VL - 71
JO - Pediatric Blood & Cancer
JF - Pediatric Blood & Cancer
IS - 6
M1 - e30937
ER -