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Septin9 is involved in T-cell development and CD8(+) T-cell homeostasis

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Septin9 is involved in T-cell development and CD8(+) T-cell homeostasis. / Lassen, Louise Berkhoudt; Füchtbauer, Annette; Schmitz, Alexander; Sørensen, Annette Balle; Pedersen, Finn Skou; Füchtbauer, Ernst-Martin.

In: Cell and Tissue Research, Vol. 352, No. 3, 04.05.2013, p. 695-705.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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MLA

Lassen, Louise Berkhoudt et al. "Septin9 is involved in T-cell development and CD8(+) T-cell homeostasis". Cell and Tissue Research. 2013, 352(3). 695-705. https://doi.org/10.1007/s00441-013-1618-6

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Author

Lassen, Louise Berkhoudt ; Füchtbauer, Annette ; Schmitz, Alexander ; Sørensen, Annette Balle ; Pedersen, Finn Skou ; Füchtbauer, Ernst-Martin. / Septin9 is involved in T-cell development and CD8(+) T-cell homeostasis. In: Cell and Tissue Research. 2013 ; Vol. 352, No. 3. pp. 695-705.

Bibtex

@article{239c7bff9dcf4af1b88f220ce1128ca1,
title = "Septin9 is involved in T-cell development and CD8(+) T-cell homeostasis",
abstract = "SEPTIN9 (SEPT9) is a filament-forming protein involved in numerous cellular processes. We have used a conditional knock out allele of Sept9 to specifically delete Sept9 in T-cells. As shown by fluorescence-activated cell sorting, loss of Sept9 at an early thymocyte stage in the thymus results in increased numbers of double-negative cells indicating that SEPT9 is involved in the transition from the double-negative stage during T-cell development. Accordingly, the relative numbers of mature T-cells in the periphery are decreased in mice with a T-cell-specific deletion of Sept9. Proliferation of Sept9-deleted CD8(+) T-cells from the spleen is decreased upon stimulation in culture. The altered T-cell homeostasis caused by the loss of Sept9 results in an increase of CD8(+) central memory T-cells.",
keywords = "Sept9, T-cell development, CD8+ T-cells, T-cell homeostasis, T-cell proliferation, Mice (Sept9 cond :Mx-Cre)",
author = "Lassen, {Louise Berkhoudt} and Annette F{\"u}chtbauer and Alexander Schmitz and S{\o}rensen, {Annette Balle} and Pedersen, {Finn Skou} and Ernst-Martin F{\"u}chtbauer",
year = "2013",
month = may,
day = "4",
doi = "10.1007/s00441-013-1618-6",
language = "English",
volume = "352",
pages = "695--705",
journal = "Cell and Tissue Research",
issn = "0302-766X",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Septin9 is involved in T-cell development and CD8(+) T-cell homeostasis

AU - Lassen, Louise Berkhoudt

AU - Füchtbauer, Annette

AU - Schmitz, Alexander

AU - Sørensen, Annette Balle

AU - Pedersen, Finn Skou

AU - Füchtbauer, Ernst-Martin

PY - 2013/5/4

Y1 - 2013/5/4

N2 - SEPTIN9 (SEPT9) is a filament-forming protein involved in numerous cellular processes. We have used a conditional knock out allele of Sept9 to specifically delete Sept9 in T-cells. As shown by fluorescence-activated cell sorting, loss of Sept9 at an early thymocyte stage in the thymus results in increased numbers of double-negative cells indicating that SEPT9 is involved in the transition from the double-negative stage during T-cell development. Accordingly, the relative numbers of mature T-cells in the periphery are decreased in mice with a T-cell-specific deletion of Sept9. Proliferation of Sept9-deleted CD8(+) T-cells from the spleen is decreased upon stimulation in culture. The altered T-cell homeostasis caused by the loss of Sept9 results in an increase of CD8(+) central memory T-cells.

AB - SEPTIN9 (SEPT9) is a filament-forming protein involved in numerous cellular processes. We have used a conditional knock out allele of Sept9 to specifically delete Sept9 in T-cells. As shown by fluorescence-activated cell sorting, loss of Sept9 at an early thymocyte stage in the thymus results in increased numbers of double-negative cells indicating that SEPT9 is involved in the transition from the double-negative stage during T-cell development. Accordingly, the relative numbers of mature T-cells in the periphery are decreased in mice with a T-cell-specific deletion of Sept9. Proliferation of Sept9-deleted CD8(+) T-cells from the spleen is decreased upon stimulation in culture. The altered T-cell homeostasis caused by the loss of Sept9 results in an increase of CD8(+) central memory T-cells.

KW - Sept9

KW - T-cell development

KW - CD8+ T-cells

KW - T-cell homeostasis

KW - T-cell proliferation

KW - Mice (Sept9 cond :Mx-Cre)

U2 - 10.1007/s00441-013-1618-6

DO - 10.1007/s00441-013-1618-6

M3 - Journal article

C2 - 23644740

VL - 352

SP - 695

EP - 705

JO - Cell and Tissue Research

JF - Cell and Tissue Research

SN - 0302-766X

IS - 3

ER -