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Septin9 is involved in T-cell development and CD8(+) T-cell homeostasis

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SEPTIN9 (SEPT9) is a filament-forming protein involved in numerous cellular processes. We have used a conditional knock out allele of Sept9 to specifically delete Sept9 in T-cells. As shown by fluorescence-activated cell sorting, loss of Sept9 at an early thymocyte stage in the thymus results in increased numbers of double-negative cells indicating that SEPT9 is involved in the transition from the double-negative stage during T-cell development. Accordingly, the relative numbers of mature T-cells in the periphery are decreased in mice with a T-cell-specific deletion of Sept9. Proliferation of Sept9-deleted CD8(+) T-cells from the spleen is decreased upon stimulation in culture. The altered T-cell homeostasis caused by the loss of Sept9 results in an increase of CD8(+) central memory T-cells.
Original languageEnglish
JournalCell and Tissue Research
Volume352
Issue3
Pages (from-to)695-705
Number of pages11
ISSN0302-766X
DOIs
Publication statusPublished - 4 May 2013

    Research areas

  • Sept9, T-cell development, CD8+ T-cells, T-cell homeostasis, T-cell proliferation, Mice (Sept9 cond :Mx-Cre)

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