Sensory eye irritation in humans exposed to mixtures of volatile organic compounds

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  • Anne Hempel Hempel-Jørgensen, Denmark
  • Søren K. Kjærgaard
  • Lars Mølhave, Denmark
  • Kenneth H. Hudnell, United States
  • Institute of Environmental and Occupational Medicine
Eight subjects participated in a controlled eyes-only exposure study of human sensory irritation in ocular mucosal tissue. The authors investigated dose-response properties and the additive effects of three mixtures of volatile organic compounds. The dose-response relationships for these mixtures showed increases in response intensity as concentration increased. Replication of exposure did not result in significantly different dose- response relationships. Moreover, the result implied that components of the three mixtures interacted additively to produce ocular irritation, a result referred to as simple agonism. Finally, the authors addressed the comparability of two methods to measure sensory irritation intensity (visual analogue scale and a comparative scale). The results indicated that the two rating methods produced highly comparable results.
Original languageEnglish
JournalArch. of Environm. Health
Volume54
Issue6
Pages (from-to)416-424
Number of pages9
DOIs
Publication statusPublished - Nov 1999

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