Self-assembled nanoparticles of modified-chitosan conjugates for the sustained release of dl-α-tocopherol

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  • Javier Perez Quinones, University of Havana, Cuba
  • Kurt Vesterager Gothelf
  • Jørgen Kjems
  • Chuanxu Yang, Denmark
  • Angeles Maria Heras Caballero, Universidad Complutense de Madrid, Spain
  • Claudia Schmidt, Department of Chemistry, University of Paderborn, Germany
  • Carlos Peniche Covas, Center of Biomaterials, University of Havana, Cuba
Synthetic O6-succinylated chitosan and commercial glycol chitosan were covalently linked to dl-α-tocopheryl monoesters for controlled release of vitamin E. These conjugates formed self-assembled nanoparticles in aqueous solution with 254–496 nm mean diameters and dl-α-tocopherol contents between 27 and 39% (w/w). The particles appeared as 40–75 nm almost spherical nanoparticles when studied by scanning and transmission electron microscopy upon drying. Drug linking to chitosan matrix was confirmed by FTIR spectroscopy and proton NMR. Conjugates were also characterized by differential scanning calorimetry and wide-angle X-ray diffraction. In vitro tocopherol release studies performed in water at acid pH indicated a drug release dependence on drug content, hydrated particle sizes and employed chitosan derivative. Almost constant release rates were observed the first 7 h. The obtained nanoparticles exhibited radical scavenging activity in DPPH essay. The potential of these nanoparticles was also demonstrated by the enhancement of HMVEC cell proliferation
Original languageEnglish
JournalCarbohydrate Polymers
Pages (from-to)856-864
Number of pages9
Publication statusPublished - 30 Jan 2013

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