Aarhus University Seal

Self-assembled composite matrix in a hierarchical 3-D scaffold for bone tissue engineering

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Muwan Chen
  • Dang Quang Svend Le, Denmark
  • Anette Baatrup, Denmark
  • Jens Vinge Nygaard
  • San Hein, Denmark
  • Lea Bjerre, Denmark
  • Moustapha Kassem, Department of Endocrinology and Metabolism, Odense University Hospital, 5000 Odense C, Denmark
  • Zou Xuenong, Denmark
  • Cody Bünger, Denmark
It is of high clinical relevance in bone tissue engineering that scaffolds promote a high seeding efficiency of cells capable of osteogenic differentiation, such as human bone marrow-derived mesenchymal stem cells (hMSCs). We evaluated the effects of a novel polycaprolactone (PCL) scaffold on hMSC seeding efficiency, proliferation, distribution and differentiation. Porous PCL meshes prepared by fused deposition modeling (FDM) were embedded in matrix of hyaluronic acid, methylated collagen and terpolymer via polyelectrolyte complex coacervation. Scaffolds were cultured statically and dynamically in osteogenic stimulation medium for up to 28days. Compared to naked PCL scaffolds, embedded scaffolds provided a higher cell seeding efficiency (t-test, P
Translated title of the contributionSelvopbyggende kompositmatriks i et hierarkisk 3-D skaffold til tissue engineering
Original languageEnglish
JournalActa Biomaterialia
Volume7
Issue5
Pages (from-to)2244-55
ISSN1742-7061
DOIs
Publication statusPublished - 2011

See relations at Aarhus University Citationformats

Download statistics

No data available

ID: 34209156