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Self-assembled composite matrix in a hierarchical 3-D scaffold for bone tissue engineering

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  • Muwan Chen
  • Dang Quang Svend Le, Denmark
  • Anette Baatrup, Denmark
  • Jens Vinge Nygaard
  • San Hein, Denmark
  • Lea Bjerre, Denmark
  • Moustapha Kassem, Odense Sygehus, Denmark
  • Zou Xuenong, Denmark
  • Cody Bünger, Denmark
It is of high clinical relevance in bone tissue engineering that scaffolds promote a high seeding efficiency of cells capable of osteogenic differentiation, such as human bone marrow-derived mesenchymal stem cells (hMSCs). We evaluated the effects of a novel polycaprolactone (PCL) scaffold on hMSC seeding efficiency, proliferation, distribution and differentiation. Porous PCL meshes prepared by fused deposition modeling (FDM) were embedded in matrix of hyaluronic acid, methylated collagen and terpolymer via polyelectrolyte complex coacervation. Scaffolds were cultured statically and dynamically in osteogenic stimulation medium for up to 28days. Compared to naked PCL scaffolds, embedded scaffolds provided a higher cell seeding efficiency (t-test, P
Translated title of the contributionSelvopbyggende kompositmatriks i et hierarkisk 3-D skaffold til tissue engineering
Original languageEnglish
JournalActa Biomaterialia
Pages (from-to)2244-55
Publication statusPublished - 2011

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