Self-forming double-crosslinked hydrogels by the marriage of catechols and enzyme mimetic polymers

Yaqing Chen; Erik Misselwitz; Asger Holm Agergaard; Amanda Andersen; Carsten Pedersen; Henrik Birkedal

doi:10.1039/d2cc01290a

Self-forming double-crosslinked hydrogels by the marriage of catechols and enzyme mimetic polymers

Yaqing Chen, Erik Misselwitz, Asger Holm Agergaard, Amanda Andersen, Carsten Pedersen, Henrik Birkedal^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

1 Citation (Scopus)

Abstract

Self-forming double-crosslinked (DC) hydrogels were designed by incorporating enzyme-mimicking metal coordination polymer crosslinks and catechol chemistry. A macromolecular tris-histidine copper complex acted both as part of the hydrogel network and as a catalyst of catechol oxidation to induce a second hydrogel network by covalent crosslinking of catechol functionalized polymers thus giving catalytic control over hydrogel crosslinking.

Original language	English
Journal	Chemical communications (Cambridge, England)
Volume	58
Issue	45
Pages (from-to)	6526-6529
Number of pages	4
ISSN	1359-7345
DOIs	https://doi.org/10.1039/d2cc01290a
Publication status	Published - 10 May 2022

Keywords

LINKING
MECHANICS
MIMICKING
PROTEIN
COPPER(II)
MUSSEL
TYROSINASE
COMPLEXES
NEREIS
ZINC
Catechols/chemistry
Metals/chemistry
Oxidation-Reduction
Cross-Linking Reagents/chemistry
Hydrogels/chemistry
Polymers/chemistry

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10.1039/d2cc01290a

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title = "Self-forming double-crosslinked hydrogels by the marriage of catechols and enzyme mimetic polymers",

abstract = "Self-forming double-crosslinked (DC) hydrogels were designed by incorporating enzyme-mimicking metal coordination polymer crosslinks and catechol chemistry. A macromolecular tris-histidine copper complex acted both as part of the hydrogel network and as a catalyst of catechol oxidation to induce a second hydrogel network by covalent crosslinking of catechol functionalized polymers thus giving catalytic control over hydrogel crosslinking.",

keywords = "LINKING, MECHANICS, MIMICKING, PROTEIN, COPPER(II), MUSSEL, TYROSINASE, COMPLEXES, NEREIS, ZINC, Catechols/chemistry, Metals/chemistry, Oxidation-Reduction, Cross-Linking Reagents/chemistry, Hydrogels/chemistry, Polymers/chemistry",

author = "Yaqing Chen and Erik Misselwitz and Agergaard, {Asger Holm} and Amanda Andersen and Carsten Pedersen and Henrik Birkedal",

note = "Publisher Copyright: {\textcopyright} 2022 The Royal Society of Chemistry.",

year = "2022",

month = may,

day = "10",

doi = "10.1039/d2cc01290a",

language = "English",

volume = "58",

pages = "6526--6529",

journal = "Chemical communications (Cambridge, England)",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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Self-forming double-crosslinked hydrogels by the marriage of catechols and enzyme mimetic polymers. / Chen, Yaqing; Misselwitz, Erik; Agergaard, Asger Holm et al.
In: Chemical communications (Cambridge, England), Vol. 58, No. 45, 10.05.2022, p. 6526-6529.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Self-forming double-crosslinked hydrogels by the marriage of catechols and enzyme mimetic polymers

AU - Chen, Yaqing

AU - Misselwitz, Erik

AU - Agergaard, Asger Holm

AU - Andersen, Amanda

AU - Pedersen, Carsten

AU - Birkedal, Henrik

PY - 2022/5/10

Y1 - 2022/5/10

N2 - Self-forming double-crosslinked (DC) hydrogels were designed by incorporating enzyme-mimicking metal coordination polymer crosslinks and catechol chemistry. A macromolecular tris-histidine copper complex acted both as part of the hydrogel network and as a catalyst of catechol oxidation to induce a second hydrogel network by covalent crosslinking of catechol functionalized polymers thus giving catalytic control over hydrogel crosslinking.

AB - Self-forming double-crosslinked (DC) hydrogels were designed by incorporating enzyme-mimicking metal coordination polymer crosslinks and catechol chemistry. A macromolecular tris-histidine copper complex acted both as part of the hydrogel network and as a catalyst of catechol oxidation to induce a second hydrogel network by covalent crosslinking of catechol functionalized polymers thus giving catalytic control over hydrogel crosslinking.

KW - LINKING

KW - MECHANICS

KW - MIMICKING

KW - PROTEIN

KW - COPPER(II)

KW - MUSSEL

KW - TYROSINASE

KW - COMPLEXES

KW - NEREIS

KW - ZINC

KW - Catechols/chemistry

KW - Metals/chemistry

KW - Oxidation-Reduction

KW - Cross-Linking Reagents/chemistry

KW - Hydrogels/chemistry

KW - Polymers/chemistry

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U2 - 10.1039/d2cc01290a

DO - 10.1039/d2cc01290a

M3 - Journal article

C2 - 35579021

AN - SCOPUS:85131217277

SN - 1359-7345

VL - 58

SP - 6526

EP - 6529

JO - Chemical communications (Cambridge, England)

JF - Chemical communications (Cambridge, England)

IS - 45

ER -

Self-forming double-crosslinked hydrogels by the marriage of catechols and enzyme mimetic polymers

Abstract

Keywords

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