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Selective Synthesis of Imines by Photo-Oxidative Amine Cross-Condensation Catalyzed by PCN-222(Pd)
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Documents
- acssuschemeng.1c04389
Final published version, 1.61 MB, PDF document
DOI
- https://doi.org/10.1021/acssuschemeng.1c04389
Final published version
- Aitor Bermejo-López, Stockholm University ,
- Sergio Carrasco, Stockholm University ,
- Pedro J. Tortajada, Stockholm University ,
- Kenji P.M. Kopf, Stockholm University ,
- Amparo Sanz-Marco, Stockholm University ,
- Mathias S. Hvid, Stockholm University ,
- Nina Lock
- Belén Martín-Matute, Stockholm University
Palladium-metalated PCN-222 enables the aerobic photo-oxidative cross-condensation of anilines with benzylic amines yielding a series of linear and cyclic imines. The reaction is very efficient under mild conditions, which allows the isolation of simple, yet elusive, intermediates such as 2-(benzylideneamino)aniline and 2-(benzylideneamino)phenols. Recyclability studies show excellent activity and selectivity after five runs. The methodology was successfully applied for the synthesis of an antitumor agent (PMX-610).
| Original language | English |
|---|---|
| Journal | ACS Sustainable Chemistry and Engineering |
| Volume | 9 |
| Issue | 43 |
| Pages (from-to) | 14405-14415 |
| Number of pages | 11 |
| ISSN | 2168-0485 |
| DOIs | |
| Publication status | Published - Nov 2021 |
- heterogeneous catalysis, imines, MOF, photoredox, recyclability
Research areas
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