Selective patient and public involvement: The promise and perils of pharmaceutical intervention for autism

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  • Ginny Russell, Exeter University, United Kingdom
  • Sandy Starr, Progress Educational Trust, United Kingdom
  • Chris Elphick, United Kingdom
  • Raffaele Rodogno
  • Ilina Singh, University of Oxford, Oxford, United Kingdom
Background: Guidelines suggest the patient community should be consulted from the outset when designing and implementing basic biomedical research, but such patient communities may include conflicting views. We examined how engagement occurred in one such instance.
Objective: Our objective was to scrutinize patient and public involvement (PPI) by a pan-European biomedical consortium working to develop drugs to treat autism. We aimed to use this as an example to illustrate how PPI has been utilized in biomedical research.
Setting, participants and analysis: Two public events, one in the UK and one in Denmark were conducted as part of the consortium’s on-going PPI activities in 2014 and 2015. Sixty-six individuals submitted written comments on the consortium’s re- search after these events. The textual data produced were analysed using a thematic approach. Approximately 71% of respondents reported themselves to be adults on the autism spectrum or parents of children with autism.
Results: The themes identified illustrated major differences between some community concerns and the biomedical research agenda. While treating autism per se. was seen as problematic by some, treating specific co-occurring problems was seen as helpful in some circumstances. The biomedical consortium selected PPI with a limited user view- point at its outset and more widely once basic research was on-going.
Discussion: This case illustrates what we term “selective PPI” where only a sympa- thetic and/or limited patient viewpoint is included. Findings highlight the perils of using selective PPI to legitimise scientific endeavours, and the possibilities for con- structive dialogue.
Original languageEnglish
JournalHealth Expectations
Pages (from-to)466-473
Number of pages8
Publication statusPublished - 2018

    Research areas

  • autism, biomedicine, patient and public involvement, PPI

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