SELECTIVE C-2 AND C-4 DEACYLATION AND ACYLATION OF TAXOL - THE FIRST SYNTHESIS OF A C-4 SUBSTITUTED TAXOL ANALOG

GI GEORG*, SM ALI, TC BOGE, A DATTA, L FALBORG, RH HIMES

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

Hydrolytic procedures for selective 2-debenzoylation and 2,4-dideacylation of 2'-0-tert-butyldimethylsilyl-7-0-(triethylsilyl)taxol are reported. The first synthesis and biological evaluation of a 4-substituted analogue, 4-deacetyl-4-isobutanoyltaxol, is presented. The chemistry described in this letter is suitable for the facile synthesis of taxol congeners modified at C-2 and/or C-4.

Original languageEnglish
JournalTetrahedron Letters
Volume35
Issue48
Pages (from-to)8931-8934
Number of pages4
ISSN0040-4039
Publication statusPublished - 28 Nov 1994

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