TY - JOUR
T1 - Selecting the Best Animal Model of Parkinson's Disease for Your Research Purpose
T2 - Insight from in vivo PET Imaging Studies
AU - Real, Caroline Cristiano
AU - Binda, Karina Henrique
AU - Thomsen, Majken Borup
AU - Lillethorup, Thea Pinholt
AU - Brooks, David James
AU - Landau, Anne M
N1 - Copyright© Bentham Science Publishers; For any queries, please email at [email protected].
PY - 2023/2
Y1 - 2023/2
N2 - Parkinson's disease (PD) is a debilitating neurodegenerative multisystem disorder leading to motor and non-motor symptoms in millions of individuals. Despite intense research, there is still no cure, and early disease biomarkers are lacking. Animal models of PD have been inspired by basic elements of its pathogenesis, such as dopamine dysfunction, alpha-synuclein accumulation, neuroinflammation and disruption of protein degradation, and these have been crucial for a deeper understanding of the mechanisms of pathology, the identification of biomarkers, and evaluation of novel therapies. Imaging biomarkers are non-invasive tools to assess disease progression and response to therapies; their discovery and validation have been an active field of translational re-search. Here, we highlight different considerations of animal models of PD that can be applied to future research, in terms of their suitability to answer different research questions. We provide the reader with important considerations of the best choice of model to use based on the disease features of each model, including issues related to different species. In addition, positron emission to mography studies conducted in PD animal models in the last 5 years are presented. With a variety of different species, interventions and genetic information, the choice of the most appropriate model to answer research questions can be daunting, especially since no single model recapitulates all aspects of this complex disorder. Appropriate animal models in conjunction with in vivo molecular imaging tools, if selected properly, can be a powerful combination for the assessment of novel therapies and developing tools for early diagnosis.
AB - Parkinson's disease (PD) is a debilitating neurodegenerative multisystem disorder leading to motor and non-motor symptoms in millions of individuals. Despite intense research, there is still no cure, and early disease biomarkers are lacking. Animal models of PD have been inspired by basic elements of its pathogenesis, such as dopamine dysfunction, alpha-synuclein accumulation, neuroinflammation and disruption of protein degradation, and these have been crucial for a deeper understanding of the mechanisms of pathology, the identification of biomarkers, and evaluation of novel therapies. Imaging biomarkers are non-invasive tools to assess disease progression and response to therapies; their discovery and validation have been an active field of translational re-search. Here, we highlight different considerations of animal models of PD that can be applied to future research, in terms of their suitability to answer different research questions. We provide the reader with important considerations of the best choice of model to use based on the disease features of each model, including issues related to different species. In addition, positron emission to mography studies conducted in PD animal models in the last 5 years are presented. With a variety of different species, interventions and genetic information, the choice of the most appropriate model to answer research questions can be daunting, especially since no single model recapitulates all aspects of this complex disorder. Appropriate animal models in conjunction with in vivo molecular imaging tools, if selected properly, can be a powerful combination for the assessment of novel therapies and developing tools for early diagnosis.
KW - Animals
KW - Biomarkers
KW - Disease Models, Animal
KW - Disease Progression
KW - Parkinson Disease/metabolism
KW - Positron-Emission Tomography
KW - alpha-Synuclein/metabolism
KW - Animal models
KW - Autoradiography
KW - Non-human primate
KW - Minipig
KW - Rodent
KW - Positron emission tomography
KW - Alpha-synuclein
KW - Parkinson’s disease
UR - http://www.scopus.com/inward/record.url?scp=85159759888&partnerID=8YFLogxK
U2 - 10.2174/1570159X21666230216101659
DO - 10.2174/1570159X21666230216101659
M3 - Review
C2 - 36797611
SN - 1570-159X
VL - 21
SP - 1241
EP - 1272
JO - Current Neuropharmacology
JF - Current Neuropharmacology
IS - 5
ER -