Selected factors of the innate immunity in Polish patients suffering from pulmonary tuberculosis

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  • Anna Sokołowska, Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232, Łódź, Poland.
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  • Anna S Świerzko, Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232, Łódź, Poland.
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  • Agnieszka Szala-Poździej, Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232, Łódź, Poland.
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  • Ewa Augustynowicz-Kopeć, Institute of Tuberculosis and Lung Diseases, Plocka 26, 01-138, Warsaw, Poland.
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  • Monika Kozińska, Institute of Tuberculosis and Lung Diseases, Plocka 26, 01-138, Warsaw, Poland.
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  • Tomasz Niemiec, The Voivodeship Hospital of Lung Diseases in Jaroszowiec, Kolejowa 1a, 32-312, Jaroszowiec, Poland.
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  • Maria Błachnio, Masovian Center of Lung Diseases and Tuberculosis Treatment, Narutowicza 80, 05-400, Otwock, Poland.
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  • Dagmara Borkowska-Tatar, Institute of Tuberculosis and Lung Diseases, Plocka 26, 01-138, Warsaw, Poland.
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  • Jens C Jensenius
  • Steffen Thiel
  • Jarosław Dziadek, Laboratory of Mycobacterium Genetics and Physiology, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232, Łódź, Poland.
  • ,
  • Maciej Cedzyński, Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232, Łódź, Poland. Electronic address: mcedzynski@cbm.pan.pl.

We conducted a prospective study of 453 Polish patients suffering from pulmonary tuberculosis and 267 healthy controls. Selected polymorphisms of the genes encoding for collectins, ficolins and MBL-associated serine protease 2 were investigated as were serum concentrations of mannose-binding lectin, surfactant protein D, ficolin-1 and ficolin-3. The number of MBL2 gene exon 1 variant allele carriers was significantly higher in patients, compared with controls. The homozygosity for SFTPA2 +26 C > A SNP variant allele occurred less commonly within TB, while homozygosity for the FCN1 -542 G > A major allele was less frequent within the control group. Two patients were found MASP-2-deficient. Serum concentrations of MBL, SP-D and ficolin-1 were higher amongst patients while the converse was found for ficolin-3. Ficolin-1 had high specificity to differentiate between individuals with tuberculosis and healthy persons and therefore may be considered potential disease marker.

Original languageEnglish
Article number151905
JournalImmunobiology
Volume225
Issue3
Pages (from-to)151905
ISSN0171-2985
DOIs
Publication statusPublished - May 2020

    Research areas

  • Collectin, Ficolin, MASP, Pulmonary surfactant, Tuberculosis

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