Scopoletin from Lasianthus lucidus Blume (Rubiaceae): A potential antimicrobial against multidrug-resistant Pseudomonas aeruginosa

Tiwtawat Napiroon, Markus Bacher, Henrik Balslev, Kwankamol Tawaitakham, Wichai Santimaleeworagun, Srunya Vajrodaya*

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

1 Citation (Scopus)
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Abstract

A bioassay-guided study of stem bark lipophilic extracts led to the isolation of a bioactive compound from Lasianthus lucidus Blume species related to traditional medicine for treatment of wound infections, bleeding, and fevers. Scopoletin (7-hydroxy-6-methoxycoumarin) could be isolated from stem bark extract yielding 1.4 μmol/g by dry weight. The minimum inhibitory concentrations of extracts and scopoletin proved to be effective against both strains of Pseudomonas aeruginosa ATCC 27853 (AmpC β-lactamase producing strain) and P. aeruginosa DMSC 37166 (clinical strain). They revealed the highest antibacterial effect at 128 μg/ml and morphological changes on bacterial cells were demonstrated by Field Emission Scanning Electron Microscope. The lipophilic extracts and the purified scopoletin from L. lucidus have clear antibacterial activities, especially acting against P. aeruginosa strains. They produce cell lysis, inflated swelling cell walls and cell walls sinking into cells in the same way.

Original languageEnglish
JournalJournal of Applied Pharmaceutical Science
Volume8
Issue9
Pages (from-to)1-6
Number of pages6
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Ethnomedicines
  • Infectious diseases
  • Lasianthus
  • Scopoletin

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