Schema-dependent gene activation and memory encoding in neocortex

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review


  • Dorothy Tse, Centre for Cognitive and Neural Systems, University of Edinburgh, Edinburgh EH8 9JZ, UK.
  • ,
  • Tomonori Takeuchi
  • Masaki Kakeyama
  • ,
  • Yasushi Kajii
  • ,
  • Hiroyuki Okuno
  • ,
  • Chiharu Tohyama
  • ,
  • Haruhiko Bito
  • ,
  • Richard G M Morris

When new learning occurs against the background of established prior knowledge, relevant new information can be assimilated into a schema and thereby expand the knowledge base. An animal model of this important component of memory consolidation reveals that systems memory consolidation can be very fast. In experiments with rats, we found that the hippocampal-dependent learning of new paired associates is associated with a striking up-regulation of immediate early genes in the prelimbic region of the medial prefrontal cortex, and that pharmacological interventions targeted at that area can prevent both new learning and the recall of remotely and even recently consolidated information. These findings challenge the concept of distinct fast (hippocampal) and slow (cortical) learning systems, and shed new light on the neural mechanisms of memory assimilation into schemas.

Original languageEnglish
Pages (from-to)891-5
Number of pages5
Publication statusPublished - 12 Aug 2011

    Research areas

  • 6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology, Animals, Cues, Cytoskeletal Proteins/genetics, Early Growth Response Protein 1/genetics, Genes, Immediate-Early, Hippocampus/physiology, Learning, Male, Memory, Mental Recall, Neocortex/physiology, Nerve Tissue Proteins/genetics, Prefrontal Cortex/physiology, Rats, Receptors, AMPA/antagonists & inhibitors, Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors, Synaptic Transmission/drug effects, Transcriptional Activation, Up-Regulation

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