Scaffolded DNA Origami of a DNA Tetrahedron Molecular Container

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  • Yongang Ke, Arizona State University
  • ,
  • Jaswinder Sharma, Arizona State University
  • ,
  • Minghui Liu, Arizona State University
  • ,
  • Kasper Jahn, Denmark
  • Yan Liu, Arizona State University
  • ,
  • Hao Yan, Arizona State University
  • Department of Molecular Biology
  • iNano-School
We describe a strategy of scaffolded DNA origami to design and construct 3D molecular cages of tetrahedron geometry with inside volume
closed by triangular faces. Each edge of the triangular face is ∼54 nm in dimension. The estimated total external volume and the internal
cavity of the triangular pyramid are about 1.8 × 10-23 and 1.5 × 10-23 m3, respectively. Correct formation of the tetrahedron DNA cage was
verified by gel electrophoresis, atomic force microscopy, transmission electron microscopy, and dynamic light scattering techniques.
Original languageDanish
JournalNano Letters
Pages (from-to)2445
Number of pages2,447
Publication statusPublished - 2009

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