Scaffolded DNA Origami of a DNA Tetrahedron Molecular Container

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  • Yongang Ke, Arizona State University
  • ,
  • Jaswinder Sharma, Arizona State University
  • ,
  • Minghui Liu, Arizona State University
  • ,
  • Kasper Jahn, Denmark
  • Yan Liu, Arizona State University
  • ,
  • Hao Yan, Arizona State University
  • Department of Molecular Biology
  • iNano-School
We describe a strategy of scaffolded DNA origami to design and construct 3D molecular cages of tetrahedron geometry with inside volume
closed by triangular faces. Each edge of the triangular face is ∼54 nm in dimension. The estimated total external volume and the internal
cavity of the triangular pyramid are about 1.8 × 10-23 and 1.5 × 10-23 m3, respectively. Correct formation of the tetrahedron DNA cage was
verified by gel electrophoresis, atomic force microscopy, transmission electron microscopy, and dynamic light scattering techniques.
Original languageDanish
JournalNano Letters
Volume6
Issue9
Pages (from-to)2445
Number of pages2,447
ISSN1530-6984
Publication statusPublished - 2009

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