Salivary gland carcinoma in Denmark: a national update and follow-up on incidence, histology, and outcome

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Salivary gland carcinoma in Denmark : a national update and follow-up on incidence, histology, and outcome. / Westergaard-Nielsen, Marie; Godballe, Christian; Eriksen, Jesper Grau; Larsen, Stine Rosenkilde; Kiss, Katalin; Agander, Tina; Ulhoi, Benedicte Parm; Charabi, Birgitte; Klug, Tejs Ehlers; Jacobsen, Henrik; Johansen, Jorgen; Kristensen, Claus Andrup; Andersen, Elo; Andersen, Maria; Andreasen, Simon; Bjorndal, Kristine.

In: European Archives of Oto-Rhino-Laryngology, Vol. 278, No. 4, 04.2021, p. 1179-1188.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Westergaard-Nielsen, M, Godballe, C, Eriksen, JG, Larsen, SR, Kiss, K, Agander, T, Ulhoi, BP, Charabi, B, Klug, TE, Jacobsen, H, Johansen, J, Kristensen, CA, Andersen, E, Andersen, M, Andreasen, S & Bjorndal, K 2021, 'Salivary gland carcinoma in Denmark: a national update and follow-up on incidence, histology, and outcome', European Archives of Oto-Rhino-Laryngology, vol. 278, no. 4, pp. 1179-1188. https://doi.org/10.1007/s00405-020-06205-2

APA

Westergaard-Nielsen, M., Godballe, C., Eriksen, J. G., Larsen, S. R., Kiss, K., Agander, T., Ulhoi, B. P., Charabi, B., Klug, T. E., Jacobsen, H., Johansen, J., Kristensen, C. A., Andersen, E., Andersen, M., Andreasen, S., & Bjorndal, K. (2021). Salivary gland carcinoma in Denmark: a national update and follow-up on incidence, histology, and outcome. European Archives of Oto-Rhino-Laryngology, 278(4), 1179-1188. https://doi.org/10.1007/s00405-020-06205-2

CBE

Westergaard-Nielsen M, Godballe C, Eriksen JG, Larsen SR, Kiss K, Agander T, Ulhoi BP, Charabi B, Klug TE, Jacobsen H, Johansen J, Kristensen CA, Andersen E, Andersen M, Andreasen S, Bjorndal K. 2021. Salivary gland carcinoma in Denmark: a national update and follow-up on incidence, histology, and outcome. European Archives of Oto-Rhino-Laryngology. 278(4):1179-1188. https://doi.org/10.1007/s00405-020-06205-2

MLA

Westergaard-Nielsen, Marie et al. "Salivary gland carcinoma in Denmark: a national update and follow-up on incidence, histology, and outcome". European Archives of Oto-Rhino-Laryngology. 2021, 278(4). 1179-1188. https://doi.org/10.1007/s00405-020-06205-2

Vancouver

Westergaard-Nielsen M, Godballe C, Eriksen JG, Larsen SR, Kiss K, Agander T et al. Salivary gland carcinoma in Denmark: a national update and follow-up on incidence, histology, and outcome. European Archives of Oto-Rhino-Laryngology. 2021 Apr;278(4):1179-1188. https://doi.org/10.1007/s00405-020-06205-2

Author

Westergaard-Nielsen, Marie ; Godballe, Christian ; Eriksen, Jesper Grau ; Larsen, Stine Rosenkilde ; Kiss, Katalin ; Agander, Tina ; Ulhoi, Benedicte Parm ; Charabi, Birgitte ; Klug, Tejs Ehlers ; Jacobsen, Henrik ; Johansen, Jorgen ; Kristensen, Claus Andrup ; Andersen, Elo ; Andersen, Maria ; Andreasen, Simon ; Bjorndal, Kristine. / Salivary gland carcinoma in Denmark : a national update and follow-up on incidence, histology, and outcome. In: European Archives of Oto-Rhino-Laryngology. 2021 ; Vol. 278, No. 4. pp. 1179-1188.

Bibtex

@article{ba7cfbcd194f487d9b13b4ba03c05be0,
title = "Salivary gland carcinoma in Denmark: a national update and follow-up on incidence, histology, and outcome",
abstract = "Purpose Salivary gland carcinoma is a rare disease and studies on epidemiology and outcome require data collection over many years. The aim of this study is to present an update of incidence rates, anatomical sites, histological subtypes, and survival rates based on the Danish national cohort of salivary gland carcinoma patients. Methods Data from all Danish patients with salivary gland carcinoma diagnosed from 1990 to 2015 (n = 1601) were included and analyzed following histological reevaluation and reclassification. Overall, disease-specific, and recurrence-free survival were evaluated. Prognostic factors were analyzed with multivariate Cox Hazard Regression. Results The study population consisted of 769 men and 832 women, median age 62 years (range 6-102). The most frequent anatomic site was the parotid gland (51.8%). Adenoid cystic carcinoma was the most common subtype (24.7%). The majority had tumor classification T1/T2 (65.3%). The mean crude incidence was 1.2/100.000/year with an increase of 1.5% per year. There was no increase in age-adjusted incidence. The 5-, 10-, and 20-year survival rates were for overall survival 68, 52, and 35%, for disease-specific survival, 77, 69, and 64%, and for recurrence-free survival, 75, 64, and 51%, respectively. Age, high-grade histological subtype, advanced T-classification, cervical lymph node metastases, vascular invasion, and involved surgical margins had significantly negative impact on survival rates. Conclusion The age-adjusted incidence has been stable for a period of 26 years. Multivariate analysis confirmed that histological grade, advanced stage, involved surgical margins and vascular invasion are independent negative prognostic factors. Survival rates were stationary compared to earlier reports.",
keywords = "Salivary gland carcinoma, Histological subtypes, Incidence, Survival rates, Prognostic factors, INDEPENDENT PROGNOSTIC-FACTORS, ADENOID CYSTIC CARCINOMA, PAROTID-GLAND, DANISH HEAD, MALIGNANT-TUMORS, DUTCH HEAD, CANCER, NECK, SURVIVAL, MANAGEMENT",
author = "Marie Westergaard-Nielsen and Christian Godballe and Eriksen, {Jesper Grau} and Larsen, {Stine Rosenkilde} and Katalin Kiss and Tina Agander and Ulhoi, {Benedicte Parm} and Birgitte Charabi and Klug, {Tejs Ehlers} and Henrik Jacobsen and Jorgen Johansen and Kristensen, {Claus Andrup} and Elo Andersen and Maria Andersen and Simon Andreasen and Kristine Bjorndal",
year = "2021",
month = apr,
doi = "10.1007/s00405-020-06205-2",
language = "English",
volume = "278",
pages = "1179--1188",
journal = "European Archives of Oto-Rhino-Laryngology",
issn = "0937-4477",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Salivary gland carcinoma in Denmark

T2 - a national update and follow-up on incidence, histology, and outcome

AU - Westergaard-Nielsen, Marie

AU - Godballe, Christian

AU - Eriksen, Jesper Grau

AU - Larsen, Stine Rosenkilde

AU - Kiss, Katalin

AU - Agander, Tina

AU - Ulhoi, Benedicte Parm

AU - Charabi, Birgitte

AU - Klug, Tejs Ehlers

AU - Jacobsen, Henrik

AU - Johansen, Jorgen

AU - Kristensen, Claus Andrup

AU - Andersen, Elo

AU - Andersen, Maria

AU - Andreasen, Simon

AU - Bjorndal, Kristine

PY - 2021/4

Y1 - 2021/4

N2 - Purpose Salivary gland carcinoma is a rare disease and studies on epidemiology and outcome require data collection over many years. The aim of this study is to present an update of incidence rates, anatomical sites, histological subtypes, and survival rates based on the Danish national cohort of salivary gland carcinoma patients. Methods Data from all Danish patients with salivary gland carcinoma diagnosed from 1990 to 2015 (n = 1601) were included and analyzed following histological reevaluation and reclassification. Overall, disease-specific, and recurrence-free survival were evaluated. Prognostic factors were analyzed with multivariate Cox Hazard Regression. Results The study population consisted of 769 men and 832 women, median age 62 years (range 6-102). The most frequent anatomic site was the parotid gland (51.8%). Adenoid cystic carcinoma was the most common subtype (24.7%). The majority had tumor classification T1/T2 (65.3%). The mean crude incidence was 1.2/100.000/year with an increase of 1.5% per year. There was no increase in age-adjusted incidence. The 5-, 10-, and 20-year survival rates were for overall survival 68, 52, and 35%, for disease-specific survival, 77, 69, and 64%, and for recurrence-free survival, 75, 64, and 51%, respectively. Age, high-grade histological subtype, advanced T-classification, cervical lymph node metastases, vascular invasion, and involved surgical margins had significantly negative impact on survival rates. Conclusion The age-adjusted incidence has been stable for a period of 26 years. Multivariate analysis confirmed that histological grade, advanced stage, involved surgical margins and vascular invasion are independent negative prognostic factors. Survival rates were stationary compared to earlier reports.

AB - Purpose Salivary gland carcinoma is a rare disease and studies on epidemiology and outcome require data collection over many years. The aim of this study is to present an update of incidence rates, anatomical sites, histological subtypes, and survival rates based on the Danish national cohort of salivary gland carcinoma patients. Methods Data from all Danish patients with salivary gland carcinoma diagnosed from 1990 to 2015 (n = 1601) were included and analyzed following histological reevaluation and reclassification. Overall, disease-specific, and recurrence-free survival were evaluated. Prognostic factors were analyzed with multivariate Cox Hazard Regression. Results The study population consisted of 769 men and 832 women, median age 62 years (range 6-102). The most frequent anatomic site was the parotid gland (51.8%). Adenoid cystic carcinoma was the most common subtype (24.7%). The majority had tumor classification T1/T2 (65.3%). The mean crude incidence was 1.2/100.000/year with an increase of 1.5% per year. There was no increase in age-adjusted incidence. The 5-, 10-, and 20-year survival rates were for overall survival 68, 52, and 35%, for disease-specific survival, 77, 69, and 64%, and for recurrence-free survival, 75, 64, and 51%, respectively. Age, high-grade histological subtype, advanced T-classification, cervical lymph node metastases, vascular invasion, and involved surgical margins had significantly negative impact on survival rates. Conclusion The age-adjusted incidence has been stable for a period of 26 years. Multivariate analysis confirmed that histological grade, advanced stage, involved surgical margins and vascular invasion are independent negative prognostic factors. Survival rates were stationary compared to earlier reports.

KW - Salivary gland carcinoma

KW - Histological subtypes

KW - Incidence

KW - Survival rates

KW - Prognostic factors

KW - INDEPENDENT PROGNOSTIC-FACTORS

KW - ADENOID CYSTIC CARCINOMA

KW - PAROTID-GLAND

KW - DANISH HEAD

KW - MALIGNANT-TUMORS

KW - DUTCH HEAD

KW - CANCER

KW - NECK

KW - SURVIVAL

KW - MANAGEMENT

UR - http://www.scopus.com/inward/record.url?scp=85088248430&partnerID=8YFLogxK

U2 - 10.1007/s00405-020-06205-2

DO - 10.1007/s00405-020-06205-2

M3 - Journal article

C2 - 32691231

VL - 278

SP - 1179

EP - 1188

JO - European Archives of Oto-Rhino-Laryngology

JF - European Archives of Oto-Rhino-Laryngology

SN - 0937-4477

IS - 4

ER -