Salivary gland carcinoma in Denmark: a national update and follow-up on incidence, histology, and outcome

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Marie Westergaard-Nielsen, University of Southern Denmark
  • ,
  • Christian Godballe, University of Southern Denmark
  • ,
  • Jesper Grau Eriksen
  • Stine Rosenkilde Larsen, Univ Southern Denmark, Odense University Hospital, University of Southern Denmark, Odense Univ Hosp, Dept Clin Res, Dept Pathol,Clin Cell Biol
  • ,
  • Katalin Kiss, University of Copenhagen
  • ,
  • Tina Agander, University of Copenhagen
  • ,
  • Benedicte Parm Ulhoi
  • ,
  • Birgitte Charabi, Rigshosp, Rigshospitalet, University of Copenhagen, Dept Otorhinolaryngol Head & Neck Surg & Audiol
  • ,
  • Tejs Ehlers Klug
  • Henrik Jacobsen, Aalborg Univ Hosp, Aalborg University, Dept Otorhinolaryngol Head & Neck Surg
  • ,
  • Jorgen Johansen, University of Southern Denmark
  • ,
  • Claus Andrup Kristensen, University of Copenhagen
  • ,
  • Elo Andersen, Herlev Hosp, University of Copenhagen, Dept Oncol
  • ,
  • Maria Andersen, Aalborg Univ Hosp, Aalborg University, Paediat Oncol Sect, Paediat Dept
  • ,
  • Simon Andreasen, University of Copenhagen
  • ,
  • Kristine Bjorndal, University of Southern Denmark

Purpose Salivary gland carcinoma is a rare disease and studies on epidemiology and outcome require data collection over many years. The aim of this study is to present an update of incidence rates, anatomical sites, histological subtypes, and survival rates based on the Danish national cohort of salivary gland carcinoma patients. Methods Data from all Danish patients with salivary gland carcinoma diagnosed from 1990 to 2015 (n = 1601) were included and analyzed following histological reevaluation and reclassification. Overall, disease-specific, and recurrence-free survival were evaluated. Prognostic factors were analyzed with multivariate Cox Hazard Regression. Results The study population consisted of 769 men and 832 women, median age 62 years (range 6-102). The most frequent anatomic site was the parotid gland (51.8%). Adenoid cystic carcinoma was the most common subtype (24.7%). The majority had tumor classification T1/T2 (65.3%). The mean crude incidence was 1.2/100.000/year with an increase of 1.5% per year. There was no increase in age-adjusted incidence. The 5-, 10-, and 20-year survival rates were for overall survival 68, 52, and 35%, for disease-specific survival, 77, 69, and 64%, and for recurrence-free survival, 75, 64, and 51%, respectively. Age, high-grade histological subtype, advanced T-classification, cervical lymph node metastases, vascular invasion, and involved surgical margins had significantly negative impact on survival rates. Conclusion The age-adjusted incidence has been stable for a period of 26 years. Multivariate analysis confirmed that histological grade, advanced stage, involved surgical margins and vascular invasion are independent negative prognostic factors. Survival rates were stationary compared to earlier reports.

Original languageEnglish
JournalEuropean Archives of Oto-Rhino-Laryngology
Number of pages10
ISSN0937-4477
DOIs
Publication statusE-pub ahead of print - Jul 2020

    Research areas

  • Salivary gland carcinoma, Histological subtypes, Incidence, Survival rates, Prognostic factors, INDEPENDENT PROGNOSTIC-FACTORS, ADENOID CYSTIC CARCINOMA, PAROTID-GLAND, DANISH HEAD, MALIGNANT-TUMORS, DUTCH HEAD, CANCER, NECK, SURVIVAL, MANAGEMENT

See relations at Aarhus University Citationformats

ID: 195295800