ROS signalling - specificity is required

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  • Ian M Møller
  • Lee J Sweetlove, Department of Plant Sciences, University of Oxford, United Kingdom
  • Molekylær Genetik og Bioteknologi
  • Department of Genetics and Biotechnology
Reactive oxygen species (ROS) production increases in plants under stress. ROS can damage cellular components, but they can also act in signal transduction to help the cell counteract the oxidative damage in the stressed compartment. H2O2 might induce a general stress response, but it does not have the required specificity to selectively regulate nuclear genes required for dealing with localized stress, e.g. in chloroplasts or mitochondria. Here we argue that peptides deriving from proteolytic breakdown of oxidatively damaged proteins have the requisite specificity to act as secondary ROS messengers and regulate source-specific genes and in this way contribute to retrograde ROS signalling during oxidative stress. Likewise, unmodified peptides deriving from the breakdown of redundant proteins could help coordinate organellar and nuclear gene expression
Original languageEnglish
JournalTrends in Plant Science
Volume15
Issue7
Pages (from-to)370-374
Number of pages5
ISSN1360-1385
DOIs
Publication statusPublished - 2010

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