Risk-Factor Trajectories Preceding Diabetic Polyneuropathy: ADDITION-Denmark

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Risk-Factor Trajectories Preceding Diabetic Polyneuropathy : ADDITION-Denmark. / Andersen, Signe T; Witte, Daniel R; Andersen, Henning; Bjerg, Lasse; Bruun, Niels Henrik; Jørgensen, Marit E; Finnerup, Nanna B; Lauritzen, Torsten; Jensen, Troels S; Tankisi, Hatice; Charles, Morten.

In: Diabetes Care, Vol. 41, No. 9, 09.2018, p. 1955-1962.

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@article{aa06b26a435b44e4ab60f4dd2e833a12,
title = "Risk-Factor Trajectories Preceding Diabetic Polyneuropathy: ADDITION-Denmark",
abstract = "OBJECTIVE: To study cardiometabolic risk-factor trajectories (in terms of levels and changes over time) preceding diabetic polyneuropathy (DPN) 13 years after a screen-detected diagnosis of type 2 diabetes.RESEARCH DESIGN AND METHODS: We clinically diagnosed DPN in a nested case-control study of 452 people in the Danish arm of the Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care (ADDITION). By linear regression models, we estimated preceding risk-factor trajectories during 13 years. Risk of DPN was estimated by multivariate logistic regression models of each individual's risk-factor trajectory intercept and slope adjusting for sex, age, diabetes duration, height, and trial randomization group.RESULTS: Higher baseline levels of HbA1c (odds ratio [OR] 1.76 [95{\%} CI 1.37; 2.27] and OR 1.68 [95{\%} CI 1.33; 2.12] per 1{\%} and 10 mmol/mol, respectively) and steeper increases in HbA1c over time (OR 1.66 [95{\%} CI 1.21; 2.28] and OR 1.59 [95{\%} CI 1.19; 2.12] per 1{\%} and 10 mmol/mol increase during 10 years, respectively) were associated with DPN. Higher baseline levels of weight, waist circumference, and BMI were associated with DPN (OR 1.20 [95{\%} CI 1.10; 1.31] per 5 kg, OR 1.27 [95{\%} CI 1.13; 1.43] per 5 cm, and OR 1.24 [95{\%} CI 1.12; 1.38] per 2 kg/m2, respectively).CONCLUSIONS: Both higher levels and slopes of HbA1c trajectories were associated with DPN after 13 years. Our findings indicate that the rate of HbA1c increase affects the development of DPN over and above the effect of the HbA1c level. Furthermore, this study supports obesity as a risk factor for DPN.",
author = "Andersen, {Signe T} and Witte, {Daniel R} and Henning Andersen and Lasse Bjerg and Bruun, {Niels Henrik} and J{\o}rgensen, {Marit E} and Finnerup, {Nanna B} and Torsten Lauritzen and Jensen, {Troels S} and Hatice Tankisi and Morten Charles",
note = "{\circledC} 2018 by the American Diabetes Association.",
year = "2018",
month = "9",
doi = "10.2337/dc18-0392",
language = "English",
volume = "41",
pages = "1955--1962",
journal = "Diabetes Care",
issn = "0149-5992",
publisher = "American Diabetes Association",
number = "9",

}

RIS

TY - JOUR

T1 - Risk-Factor Trajectories Preceding Diabetic Polyneuropathy

T2 - ADDITION-Denmark

AU - Andersen, Signe T

AU - Witte, Daniel R

AU - Andersen, Henning

AU - Bjerg, Lasse

AU - Bruun, Niels Henrik

AU - Jørgensen, Marit E

AU - Finnerup, Nanna B

AU - Lauritzen, Torsten

AU - Jensen, Troels S

AU - Tankisi, Hatice

AU - Charles, Morten

N1 - © 2018 by the American Diabetes Association.

PY - 2018/9

Y1 - 2018/9

N2 - OBJECTIVE: To study cardiometabolic risk-factor trajectories (in terms of levels and changes over time) preceding diabetic polyneuropathy (DPN) 13 years after a screen-detected diagnosis of type 2 diabetes.RESEARCH DESIGN AND METHODS: We clinically diagnosed DPN in a nested case-control study of 452 people in the Danish arm of the Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care (ADDITION). By linear regression models, we estimated preceding risk-factor trajectories during 13 years. Risk of DPN was estimated by multivariate logistic regression models of each individual's risk-factor trajectory intercept and slope adjusting for sex, age, diabetes duration, height, and trial randomization group.RESULTS: Higher baseline levels of HbA1c (odds ratio [OR] 1.76 [95% CI 1.37; 2.27] and OR 1.68 [95% CI 1.33; 2.12] per 1% and 10 mmol/mol, respectively) and steeper increases in HbA1c over time (OR 1.66 [95% CI 1.21; 2.28] and OR 1.59 [95% CI 1.19; 2.12] per 1% and 10 mmol/mol increase during 10 years, respectively) were associated with DPN. Higher baseline levels of weight, waist circumference, and BMI were associated with DPN (OR 1.20 [95% CI 1.10; 1.31] per 5 kg, OR 1.27 [95% CI 1.13; 1.43] per 5 cm, and OR 1.24 [95% CI 1.12; 1.38] per 2 kg/m2, respectively).CONCLUSIONS: Both higher levels and slopes of HbA1c trajectories were associated with DPN after 13 years. Our findings indicate that the rate of HbA1c increase affects the development of DPN over and above the effect of the HbA1c level. Furthermore, this study supports obesity as a risk factor for DPN.

AB - OBJECTIVE: To study cardiometabolic risk-factor trajectories (in terms of levels and changes over time) preceding diabetic polyneuropathy (DPN) 13 years after a screen-detected diagnosis of type 2 diabetes.RESEARCH DESIGN AND METHODS: We clinically diagnosed DPN in a nested case-control study of 452 people in the Danish arm of the Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care (ADDITION). By linear regression models, we estimated preceding risk-factor trajectories during 13 years. Risk of DPN was estimated by multivariate logistic regression models of each individual's risk-factor trajectory intercept and slope adjusting for sex, age, diabetes duration, height, and trial randomization group.RESULTS: Higher baseline levels of HbA1c (odds ratio [OR] 1.76 [95% CI 1.37; 2.27] and OR 1.68 [95% CI 1.33; 2.12] per 1% and 10 mmol/mol, respectively) and steeper increases in HbA1c over time (OR 1.66 [95% CI 1.21; 2.28] and OR 1.59 [95% CI 1.19; 2.12] per 1% and 10 mmol/mol increase during 10 years, respectively) were associated with DPN. Higher baseline levels of weight, waist circumference, and BMI were associated with DPN (OR 1.20 [95% CI 1.10; 1.31] per 5 kg, OR 1.27 [95% CI 1.13; 1.43] per 5 cm, and OR 1.24 [95% CI 1.12; 1.38] per 2 kg/m2, respectively).CONCLUSIONS: Both higher levels and slopes of HbA1c trajectories were associated with DPN after 13 years. Our findings indicate that the rate of HbA1c increase affects the development of DPN over and above the effect of the HbA1c level. Furthermore, this study supports obesity as a risk factor for DPN.

U2 - 10.2337/dc18-0392

DO - 10.2337/dc18-0392

M3 - Journal article

VL - 41

SP - 1955

EP - 1962

JO - Diabetes Care

JF - Diabetes Care

SN - 0149-5992

IS - 9

ER -