Risk of second primary cancer from proton arc therapy of pediatric brain tumors

Laura Toussaint*, Daniel J. Indelicato, Ludvig P. Muren, Camilla H. Stokkevåg

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperLetterpeer-review

Abstract

Proton arc therapy (PAT) is currently explored for clinical implementation, despite its associated low-dose bath. This study therefore aimed at evaluating the risk of radiation-induced second primary cancer (SPC) for PAT in pediatric brain tumor patients. Two brain-specific models for SPC induction were applied in five cases to compare volumetric modulated arc therapy (VMAT), intensity modulated proton therapy (IMPT) and PAT surrogate plans. The PAT integral dose was reduced by a median of 29% compared to VMAT, and 17% compared to IMPT. For both models, the estimated SPC risks were consistently the lowest for PAT.

Original languageEnglish
Article number100480
JournalPhysics and Imaging in Radiation Oncology
Volume27
Number of pages4
DOIs
Publication statusPublished - Jul 2023

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