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Risk of psychiatric disorders, use of psychiatric hospitals and receipt of psychiatric medication in patients with brain abscess in Denmark

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  • Lars Haukali Omland, University of Copenhagen
  • ,
  • Jacob Bodilsen, Aalborg University
  • ,
  • Malte Mose Tetens, University of Copenhagen
  • ,
  • Jannik Helweg-Larsen, University of Copenhagen
  • ,
  • Jens Otto Jarløv, University of Copenhagen
  • ,
  • Morten Ziebell, University of Copenhagen
  • ,
  • Svend Ellermann-Eriksen
  • Ulrik Stenz Justesen, University of Southern Denmark
  • ,
  • Niels Frimodt-Møller, University of Copenhagen
  • ,
  • Preben Bo Mortensen
  • Niels Obel, University of Copenhagen

BACKGROUND: It is unknown whether patients diagnosed with brain abscess have an increased risk of psychiatric disorders. METHODS: In this nationwide, population-based matched cohort study from Denmark, we compared the incidence of psychiatric disorders, use of psychiatric hospitals, and receipt of psychiatric medications between patients diagnosed with brain abscess and individuals from the general population, matched on date of birth, sex, and residential area. RESULTS: We included 435 patients diagnosed with brain abscess and 3909 individuals in the comparison cohort: 61% were male and median age was 54 years. Patients diagnosed with brain abscess were more likely to suffer from comorbidity. The risk of a hospital diagnosis of psychiatric disorders was increased the first 5 years of observation. In the subpopulation, who had never been in contact with psychiatric hospitals or received psychiatric medication before study inclusion, the risk of developing psychiatric disorders was close to that of the background population, especially when we excluded dementia from this outcome. There was a substantial increase in the receipt of anxiolytics and antidepressants. The difference in the proportion of individuals who received anxiolytics and antidepressants increased from 4% (95% confidence interval [CI], 0%-7%) and 2% (95% CI, -1% to 5%) 2 years before study inclusion to 17% (95% CI, 12%-21%) and 11% (95% CI, 7%-16%) in the year after study inclusion. CONCLUSIONS: Patients with brain abscess without prior psychiatric disorders or receipt of psychiatric medicine are not at increased risk psychiatric disorders diagnosed in psychiatric hospitals, but they have an increased receipt of psychiatric medication.

Original languageEnglish
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Pages (from-to)315-322
Number of pages8
Publication statusPublished - Jan 2023

    Research areas

  • brain abscess, cohort study, psychiatric disorders, psychiatric medication, Brain Abscess/drug therapy, Mental Disorders/complications, Humans, Middle Aged, Male, Hospitals, Psychiatric, Denmark/epidemiology, Anti-Anxiety Agents/therapeutic use, Antidepressive Agents/therapeutic use, Female, Cohort Studies

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