Rifampicin-soaked silver polyester versus expanded polytetrafluoro-ethylene grafts for in situ replacement of infected grafts in a porcine randomised controlled trial

H Gao; J Sandermann; J Prag; L Lund; J S Lindholt

doi:10.1016/j.ejvs.2012.02.011

Rifampicin-soaked silver polyester versus expanded polytetrafluoro-ethylene grafts for in situ replacement of infected grafts in a porcine randomised controlled trial

H Gao, J Sandermann, J Prag, L Lund, J S Lindholt

Health

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

21 Citations (Scopus)

Abstract

BACKGROUND: To compare the efficacy of in situ replacement with rifampicin-soaked silver-coated polyester (RSSCP) to that of expanded polytetrafluoroethylene (ePTFE) graft replacements in a porcine model for early aortic prosthetic vascular graft infection (PVGI).

MATERIAL AND METHODS: Sixty pigs received polyester or silver-coated grafts with an 8 mm diameter implanted end-to-end in the infrarenal aorta, and the grafts were inoculated with approximately 10(6)Staphylococcus aureus. All developed S. aureus PVGI. Two weeks later, the 52 surviving pigs were randomised to undergo in situ graft replacement with ePTFE or RSSCP grafts followed by oral administration of 300 mg rifampicin and 750 mg ciprofloxacin twice a day, postoperatively. After three weeks, all pigs were sacrificed. In situ perigraft swabs and graft material were analysed for S. aureus quantitatively.

RESULTS: Only one out of 25 RSSCP grafts were infected with S. aureus, whereas 15 of 27 ePTFE grafts were infected after 3 weeks (OR = 0.022, 95% CI: 0.002, 0.219, P = 0.001).

CONCLUSIONS: In situ replacement with RSSCP grafts and oral rifampicin plus ciprofloxacin is more efficiency in eradicating S. aureus PVGI than ePTFE grafts treated with same oral antibiotics in a porcine aortic PVGI model.

Original language	English
Journal	European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
Volume	43
Issue	5
Pages (from-to)	582-7
Number of pages	6
ISSN	1078-5884
DOIs	https://doi.org/10.1016/j.ejvs.2012.02.011
Publication status	Published - May 2012

Keywords

Animals
Anti-Bacterial Agents
Aorta, Abdominal
Biocompatible Materials
Blood Vessel Prosthesis
Blood Vessel Prosthesis Implantation
Ciprofloxacin
Device Removal
Disease Models, Animal
Polyesters
Polymers
Polytetrafluoroethylene
Prosthesis-Related Infections
Reoperation
Rifampin
Silver Compounds
Staphylococcal Infections
Staphylococcus aureus
Swine
Comparative Study
Evaluation Studies
Journal Article
Research Support, Non-U.S. Gov't

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10.1016/j.ejvs.2012.02.011

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Gao, H., Sandermann, J., Prag, J., Lund, L., & Lindholt, J. S. (2012). Rifampicin-soaked silver polyester versus expanded polytetrafluoro-ethylene grafts for in situ replacement of infected grafts in a porcine randomised controlled trial. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 43(5), 582-7. https://doi.org/10.1016/j.ejvs.2012.02.011

Gao, H ; Sandermann, J ; Prag, J et al. / Rifampicin-soaked silver polyester versus expanded polytetrafluoro-ethylene grafts for in situ replacement of infected grafts in a porcine randomised controlled trial. In: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. 2012 ; Vol. 43, No. 5. pp. 582-7.

@article{93c4d64a01ac49beb06e0aa0ed6da434,

title = "Rifampicin-soaked silver polyester versus expanded polytetrafluoro-ethylene grafts for in situ replacement of infected grafts in a porcine randomised controlled trial",

abstract = "BACKGROUND: To compare the efficacy of in situ replacement with rifampicin-soaked silver-coated polyester (RSSCP) to that of expanded polytetrafluoroethylene (ePTFE) graft replacements in a porcine model for early aortic prosthetic vascular graft infection (PVGI).MATERIAL AND METHODS: Sixty pigs received polyester or silver-coated grafts with an 8 mm diameter implanted end-to-end in the infrarenal aorta, and the grafts were inoculated with approximately 10(6)Staphylococcus aureus. All developed S. aureus PVGI. Two weeks later, the 52 surviving pigs were randomised to undergo in situ graft replacement with ePTFE or RSSCP grafts followed by oral administration of 300 mg rifampicin and 750 mg ciprofloxacin twice a day, postoperatively. After three weeks, all pigs were sacrificed. In situ perigraft swabs and graft material were analysed for S. aureus quantitatively.RESULTS: Only one out of 25 RSSCP grafts were infected with S. aureus, whereas 15 of 27 ePTFE grafts were infected after 3 weeks (OR = 0.022, 95% CI: 0.002, 0.219, P = 0.001).CONCLUSIONS: In situ replacement with RSSCP grafts and oral rifampicin plus ciprofloxacin is more efficiency in eradicating S. aureus PVGI than ePTFE grafts treated with same oral antibiotics in a porcine aortic PVGI model.",

keywords = "Animals, Anti-Bacterial Agents, Aorta, Abdominal, Biocompatible Materials, Blood Vessel Prosthesis, Blood Vessel Prosthesis Implantation, Ciprofloxacin, Device Removal, Disease Models, Animal, Polyesters, Polymers, Polytetrafluoroethylene, Prosthesis-Related Infections, Reoperation, Rifampin, Silver Compounds, Staphylococcal Infections, Staphylococcus aureus, Swine, Comparative Study, Evaluation Studies, Journal Article, Research Support, Non-U.S. Gov't",

author = "H Gao and J Sandermann and J Prag and L Lund and Lindholt, {J S}",

year = "2012",

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doi = "10.1016/j.ejvs.2012.02.011",

language = "English",

volume = "43",

pages = "582--7",

journal = "European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery",

issn = "1078-5884",

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Gao, H, Sandermann, J, Prag, J, Lund, L & Lindholt, JS 2012, 'Rifampicin-soaked silver polyester versus expanded polytetrafluoro-ethylene grafts for in situ replacement of infected grafts in a porcine randomised controlled trial', European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, vol. 43, no. 5, pp. 582-7. https://doi.org/10.1016/j.ejvs.2012.02.011

Rifampicin-soaked silver polyester versus expanded polytetrafluoro-ethylene grafts for in situ replacement of infected grafts in a porcine randomised controlled trial. / Gao, H; Sandermann, J; Prag, J et al.
In: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Vol. 43, No. 5, 05.2012, p. 582-7.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Rifampicin-soaked silver polyester versus expanded polytetrafluoro-ethylene grafts for in situ replacement of infected grafts in a porcine randomised controlled trial

AU - Gao, H

AU - Sandermann, J

AU - Prag, J

AU - Lund, L

AU - Lindholt, J S

PY - 2012/5

Y1 - 2012/5

N2 - BACKGROUND: To compare the efficacy of in situ replacement with rifampicin-soaked silver-coated polyester (RSSCP) to that of expanded polytetrafluoroethylene (ePTFE) graft replacements in a porcine model for early aortic prosthetic vascular graft infection (PVGI).MATERIAL AND METHODS: Sixty pigs received polyester or silver-coated grafts with an 8 mm diameter implanted end-to-end in the infrarenal aorta, and the grafts were inoculated with approximately 10(6)Staphylococcus aureus. All developed S. aureus PVGI. Two weeks later, the 52 surviving pigs were randomised to undergo in situ graft replacement with ePTFE or RSSCP grafts followed by oral administration of 300 mg rifampicin and 750 mg ciprofloxacin twice a day, postoperatively. After three weeks, all pigs were sacrificed. In situ perigraft swabs and graft material were analysed for S. aureus quantitatively.RESULTS: Only one out of 25 RSSCP grafts were infected with S. aureus, whereas 15 of 27 ePTFE grafts were infected after 3 weeks (OR = 0.022, 95% CI: 0.002, 0.219, P = 0.001).CONCLUSIONS: In situ replacement with RSSCP grafts and oral rifampicin plus ciprofloxacin is more efficiency in eradicating S. aureus PVGI than ePTFE grafts treated with same oral antibiotics in a porcine aortic PVGI model.

AB - BACKGROUND: To compare the efficacy of in situ replacement with rifampicin-soaked silver-coated polyester (RSSCP) to that of expanded polytetrafluoroethylene (ePTFE) graft replacements in a porcine model for early aortic prosthetic vascular graft infection (PVGI).MATERIAL AND METHODS: Sixty pigs received polyester or silver-coated grafts with an 8 mm diameter implanted end-to-end in the infrarenal aorta, and the grafts were inoculated with approximately 10(6)Staphylococcus aureus. All developed S. aureus PVGI. Two weeks later, the 52 surviving pigs were randomised to undergo in situ graft replacement with ePTFE or RSSCP grafts followed by oral administration of 300 mg rifampicin and 750 mg ciprofloxacin twice a day, postoperatively. After three weeks, all pigs were sacrificed. In situ perigraft swabs and graft material were analysed for S. aureus quantitatively.RESULTS: Only one out of 25 RSSCP grafts were infected with S. aureus, whereas 15 of 27 ePTFE grafts were infected after 3 weeks (OR = 0.022, 95% CI: 0.002, 0.219, P = 0.001).CONCLUSIONS: In situ replacement with RSSCP grafts and oral rifampicin plus ciprofloxacin is more efficiency in eradicating S. aureus PVGI than ePTFE grafts treated with same oral antibiotics in a porcine aortic PVGI model.

KW - Animals

KW - Anti-Bacterial Agents

KW - Aorta, Abdominal

KW - Biocompatible Materials

KW - Blood Vessel Prosthesis

KW - Blood Vessel Prosthesis Implantation

KW - Ciprofloxacin

KW - Device Removal

KW - Disease Models, Animal

KW - Polyesters

KW - Polymers

KW - Polytetrafluoroethylene

KW - Prosthesis-Related Infections

KW - Reoperation

KW - Rifampin

KW - Silver Compounds

KW - Staphylococcal Infections

KW - Staphylococcus aureus

KW - Swine

KW - Comparative Study

KW - Evaluation Studies

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.ejvs.2012.02.011

DO - 10.1016/j.ejvs.2012.02.011

M3 - Journal article

C2 - 22421376

SN - 1078-5884

VL - 43

SP - 582

EP - 587

JO - European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

JF - European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

IS - 5

ER -

Gao H, Sandermann J, Prag J, Lund L, Lindholt JS. Rifampicin-soaked silver polyester versus expanded polytetrafluoro-ethylene grafts for in situ replacement of infected grafts in a porcine randomised controlled trial. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. 2012 May;43(5):582-7. doi: 10.1016/j.ejvs.2012.02.011

Rifampicin-soaked silver polyester versus expanded polytetrafluoro-ethylene grafts for in situ replacement of infected grafts in a porcine randomised controlled trial

Abstract

Keywords

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