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Revisiting the global workspace orchestrating the hierarchical organization of the human brain

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A central challenge in neuroscience is how the brain organizes the information necessary to orchestrate behaviour. Arguably, this whole-brain orchestration is carried out by a core subset of integrative brain regions, a ‘global workspace’, but its constitutive regions remain unclear. We quantified the global workspace as the common regions across seven tasks as well as rest, in a common ‘functional rich club’. To identify this functional rich club, we determined the information flow between brain regions by means of a normalized directed transfer entropy framework applied to multimodal neuroimaging data from 1,003 healthy participants and validated in participants with retest data. This revealed a set of regions orchestrating information from perceptual, long-term memory, evaluative and attentional systems. We confirmed the causal significance and robustness of our results by systematically lesioning a generative whole-brain model. Overall, this framework describes a complex choreography of the functional hierarchical organization of the human brain.

Original languageEnglish
JournalNature Human Behaviour
Volume5
Issue4
Pages (from-to)497-511
Number of pages15
ISSN2397-3374
DOIs
Publication statusPublished - Apr 2021

    Research areas

  • CINGULATE CORTEX, CONNECTOME, FUNCTIONAL CONNECTIVITY, HUMAN CEREBRAL-CORTEX, MYELIN CONTENT, NETWORK, NEURONAL MODEL, ORBITOFRONTAL CORTEX, STATE, TRANSFER ENTROPY

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