Reversing the polarity of bipolar stimulation in deep brain stimulation for essential tremor: a theoretical explanation for a useful clinical intervention

Nada Yousif; Nicola Pavese; Mohammad J Naushahi; Dipankar Nandi; Peter G Bain

doi:10.1080/13554794.2012.713495

Reversing the polarity of bipolar stimulation in deep brain stimulation for essential tremor: a theoretical explanation for a useful clinical intervention

Nada Yousif, Nicola Pavese, Mohammad J Naushahi, Dipankar Nandi, Peter G Bain

Department of Clinical Medicine - Nuclear Medicine and PET

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

9 Citations (Scopus)

Abstract

The quadripolar electrodes used for deep brain stimulation are designed to give flexibility in contact configuration, optimize therapeutic effect, and minimize side-effects. A patient with essential tremor did not tolerate a bipolar setting due to the emergence of a pulling sensation in her face. However, when the polarity of the contacts was reversed, a 70% higher voltage was tolerated. Using an electric field model, we predicted that this effect was due to the proximity of the topmost contact to the internal capsule. Post-operative imaging supported this prediction. These results demonstrate how a multi-disciplinary approach allows us to optimize parameter settings.

Original language	English
Journal	Neurocase
Volume	20
Issue	1
Pages (from-to)	10-7
Number of pages	8
ISSN	1355-4794
DOIs	https://doi.org/10.1080/13554794.2012.713495
Publication status	Published - 2014

Keywords

Deep Brain Stimulation
Essential Tremor
Female
Humans
Implantable Neurostimulators
Middle Aged
Models, Neurological
Case Reports
Journal Article
Research Support, Non-U.S. Gov't

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10.1080/13554794.2012.713495

Cite this

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title = "Reversing the polarity of bipolar stimulation in deep brain stimulation for essential tremor: a theoretical explanation for a useful clinical intervention",

abstract = "The quadripolar electrodes used for deep brain stimulation are designed to give flexibility in contact configuration, optimize therapeutic effect, and minimize side-effects. A patient with essential tremor did not tolerate a bipolar setting due to the emergence of a pulling sensation in her face. However, when the polarity of the contacts was reversed, a 70% higher voltage was tolerated. Using an electric field model, we predicted that this effect was due to the proximity of the topmost contact to the internal capsule. Post-operative imaging supported this prediction. These results demonstrate how a multi-disciplinary approach allows us to optimize parameter settings.",

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Reversing the polarity of bipolar stimulation in deep brain stimulation for essential tremor: a theoretical explanation for a useful clinical intervention. / Yousif, Nada; Pavese, Nicola; Naushahi, Mohammad J et al.
In: Neurocase, Vol. 20, No. 1, 2014, p. 10-7.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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AU - Nandi, Dipankar

AU - Bain, Peter G

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KW - Essential Tremor

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KW - Implantable Neurostimulators

KW - Middle Aged

KW - Models, Neurological

KW - Case Reports

KW - Journal Article

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Reversing the polarity of bipolar stimulation in deep brain stimulation for essential tremor: a theoretical explanation for a useful clinical intervention

Abstract

Keywords

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