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Reversible pH-responsive MRI contrast with paramagnetic polymer micelles

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  • Connor M. Ellis, University of Oxford
  • ,
  • Daohe Yuan, University of Oxford
  • ,
  • Ferenc E. Mózes, University of Oxford
  • ,
  • Jack J. Miller
  • Jason J. Davis, University of Oxford

Paramagnetically-doped polymer micelles, containing an ionizable poly(acrylic acid) (PAA) block, support high-contrast MR imaging at clinically relevant field strengths in a manner that is strongly pH responsive. A reversible switch in polymer strand charge specifically has a direct impact on local rigidity, and rotational correlation time characteristics, of the integrated Gd-chelate, driving a ∼50% amplitude switch in positive contrast.

Original languageEnglish
JournalChemical Communications
Pages (from-to)1605-1608
Number of pages4
Publication statusPublished - Jan 2023

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