TY - JOUR
T1 - Resveratrol in metabolic health: an overview of the current evidence and perspectives
AU - Poulsen, Morten Møller
AU - Jørgensen, Jens Otto Lunde
AU - Jessen, Niels
AU - Richelsen, Bjørn
AU - Pedersen, Steen Bønløkke
N1 - © 2013 New York Academy of Sciences.
PY - 2013/7
Y1 - 2013/7
N2 - In the search for novel preventive and therapeutic modalities in the management of metabolic diseases and obesity, resveratrol has attracted great attention over the past decades. Preclinical trials suggest that resveratrol mimics the metabolic effects of calorie restriction (CR) via activation of silent mating type information regulation 2 homolog 1 (SIRT1). In experimental animals, this potential translates into prevention or improvement of glucose metabolism, anti-inflammation, cancer, and nonalcoholic fatty liver disease. Moreover, and in accordance with CR, supplementation with resveratrol promotes longevity in several primitive species and protects against diet-induced metabolic abnormalities in rodents. Despite the substantial preclinical evidence, human clinical data are very scarce, and even though the compound is widely distributed as an over-the-counter human nutritional supplement, its therapeutic rationale has not been well characterized. In this review, we provide a brief overview of the field and discuss the future scientific directions of resveratrol research.
AB - In the search for novel preventive and therapeutic modalities in the management of metabolic diseases and obesity, resveratrol has attracted great attention over the past decades. Preclinical trials suggest that resveratrol mimics the metabolic effects of calorie restriction (CR) via activation of silent mating type information regulation 2 homolog 1 (SIRT1). In experimental animals, this potential translates into prevention or improvement of glucose metabolism, anti-inflammation, cancer, and nonalcoholic fatty liver disease. Moreover, and in accordance with CR, supplementation with resveratrol promotes longevity in several primitive species and protects against diet-induced metabolic abnormalities in rodents. Despite the substantial preclinical evidence, human clinical data are very scarce, and even though the compound is widely distributed as an over-the-counter human nutritional supplement, its therapeutic rationale has not been well characterized. In this review, we provide a brief overview of the field and discuss the future scientific directions of resveratrol research.
U2 - 10.1111/nyas.12141
DO - 10.1111/nyas.12141
M3 - Journal article
C2 - 23855468
SN - 0077-8923
VL - 1290
SP - 74
EP - 82
JO - New York Academy of Sciences. Annals
JF - New York Academy of Sciences. Annals
IS - 1
ER -