Resting distal to aortic pressure ratio and fractional flow reserve discordance affects the diagnostic performance of quantitative flow ratio: Results from an individual patient data meta-analysis

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Resting distal to aortic pressure ratio and fractional flow reserve discordance affects the diagnostic performance of quantitative flow ratio : Results from an individual patient data meta-analysis. / Westra, Jelmer; Eftekhari, Ashkan; Tu, Shengxian; Campo, Gianluca; Escaned, Javier; Winther, Simon; Matsuo, Hitoshi; Qu, Xinkai; Koltowski, Lukasz; Chang, Yunxiao; Liu, Tommy; Yang, Junqing; Andersen, Birgitte Krogsgaard; Wijns, William; Böttcher, Morten; Christiansen, Evald Høj; Xu, Bo; Holm, Niels Ramsing.

In: Catheterization and Cardiovascular Interventions, 01.06.2020.

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Westra, Jelmer ; Eftekhari, Ashkan ; Tu, Shengxian ; Campo, Gianluca ; Escaned, Javier ; Winther, Simon ; Matsuo, Hitoshi ; Qu, Xinkai ; Koltowski, Lukasz ; Chang, Yunxiao ; Liu, Tommy ; Yang, Junqing ; Andersen, Birgitte Krogsgaard ; Wijns, William ; Böttcher, Morten ; Christiansen, Evald Høj ; Xu, Bo ; Holm, Niels Ramsing. / Resting distal to aortic pressure ratio and fractional flow reserve discordance affects the diagnostic performance of quantitative flow ratio : Results from an individual patient data meta-analysis. In: Catheterization and Cardiovascular Interventions. 2020.

Bibtex

@article{70d37e4ffe1444158fe43f4aad5cb22d,
title = "Resting distal to aortic pressure ratio and fractional flow reserve discordance affects the diagnostic performance of quantitative flow ratio: Results from an individual patient data meta-analysis",
abstract = "OBJECTIVE: To evaluate the diagnostic performance of quantitative flow ratio (QFR) related to fractional flow reserve (FFR) and resting distal-to-aortic pressure ratio (resting Pd/Pa) concordance.BACKGROUND: QFR is a method for computation of FFR based on standard coronary angiography. It is unclear how QFR is performed in patients with discordance between FFR and resting pressure ratios (distal-to-aortic pressure ratio [Pd/Pa]).MATERIALS AND METHODS: The main comparison was the diagnostic performance of QFR with FFR as reference stratified by correspondence between FFR and resting Pd/Pa. Secondary outcome measures included distribution of clinical or procedural characteristics stratified by FFR and resting Pd/Pa correspondence.RESULTS: Four prospective studies matched the inclusion criteria. Analysis was performed on patient level data reaching a total of 759 patients and 887 vessels with paired FFR, QFR, and resting Pd/Pa. Median FFR was 0.85 (IQR: 0.77-0.90). Diagnostic accuracy of QFR with FFR as reference was higher if FFR corresponded to resting Pd/Pa: accuracy 90% (95% CI: 88-92) versus 72% (95% CI: 64-80), p < .001, and sAUC 0.95 (95% CI: 0.92-0.96) versus 0.73 (95% CI: 0.69-0.77), p < .001. Resting Pd/Pa and FFR discordance were related to age, sex, hypertension, and lesion severity.CONCLUSION: Diagnostic performance of QFR with FFR as reference is reduced for lesions with discordant FFR (≤0.80) and resting Pd/Pa (≤0.92) measurements.",
author = "Jelmer Westra and Ashkan Eftekhari and Shengxian Tu and Gianluca Campo and Javier Escaned and Simon Winther and Hitoshi Matsuo and Xinkai Qu and Lukasz Koltowski and Yunxiao Chang and Tommy Liu and Junqing Yang and Andersen, {Birgitte Krogsgaard} and William Wijns and Morten B{\"o}ttcher and Christiansen, {Evald H{\o}j} and Bo Xu and Holm, {Niels Ramsing}",
note = "{\textcopyright} 2020 Wiley Periodicals LLC.",
year = "2020",
month = jun,
day = "1",
doi = "10.1002/ccd.28976",
language = "English",
journal = "Catheterization and Cardiovascular Interventions",
issn = "1522-1946",
publisher = "JohnWiley & Sons, Inc.",

}

RIS

TY - JOUR

T1 - Resting distal to aortic pressure ratio and fractional flow reserve discordance affects the diagnostic performance of quantitative flow ratio

T2 - Results from an individual patient data meta-analysis

AU - Westra, Jelmer

AU - Eftekhari, Ashkan

AU - Tu, Shengxian

AU - Campo, Gianluca

AU - Escaned, Javier

AU - Winther, Simon

AU - Matsuo, Hitoshi

AU - Qu, Xinkai

AU - Koltowski, Lukasz

AU - Chang, Yunxiao

AU - Liu, Tommy

AU - Yang, Junqing

AU - Andersen, Birgitte Krogsgaard

AU - Wijns, William

AU - Böttcher, Morten

AU - Christiansen, Evald Høj

AU - Xu, Bo

AU - Holm, Niels Ramsing

N1 - © 2020 Wiley Periodicals LLC.

PY - 2020/6/1

Y1 - 2020/6/1

N2 - OBJECTIVE: To evaluate the diagnostic performance of quantitative flow ratio (QFR) related to fractional flow reserve (FFR) and resting distal-to-aortic pressure ratio (resting Pd/Pa) concordance.BACKGROUND: QFR is a method for computation of FFR based on standard coronary angiography. It is unclear how QFR is performed in patients with discordance between FFR and resting pressure ratios (distal-to-aortic pressure ratio [Pd/Pa]).MATERIALS AND METHODS: The main comparison was the diagnostic performance of QFR with FFR as reference stratified by correspondence between FFR and resting Pd/Pa. Secondary outcome measures included distribution of clinical or procedural characteristics stratified by FFR and resting Pd/Pa correspondence.RESULTS: Four prospective studies matched the inclusion criteria. Analysis was performed on patient level data reaching a total of 759 patients and 887 vessels with paired FFR, QFR, and resting Pd/Pa. Median FFR was 0.85 (IQR: 0.77-0.90). Diagnostic accuracy of QFR with FFR as reference was higher if FFR corresponded to resting Pd/Pa: accuracy 90% (95% CI: 88-92) versus 72% (95% CI: 64-80), p < .001, and sAUC 0.95 (95% CI: 0.92-0.96) versus 0.73 (95% CI: 0.69-0.77), p < .001. Resting Pd/Pa and FFR discordance were related to age, sex, hypertension, and lesion severity.CONCLUSION: Diagnostic performance of QFR with FFR as reference is reduced for lesions with discordant FFR (≤0.80) and resting Pd/Pa (≤0.92) measurements.

AB - OBJECTIVE: To evaluate the diagnostic performance of quantitative flow ratio (QFR) related to fractional flow reserve (FFR) and resting distal-to-aortic pressure ratio (resting Pd/Pa) concordance.BACKGROUND: QFR is a method for computation of FFR based on standard coronary angiography. It is unclear how QFR is performed in patients with discordance between FFR and resting pressure ratios (distal-to-aortic pressure ratio [Pd/Pa]).MATERIALS AND METHODS: The main comparison was the diagnostic performance of QFR with FFR as reference stratified by correspondence between FFR and resting Pd/Pa. Secondary outcome measures included distribution of clinical or procedural characteristics stratified by FFR and resting Pd/Pa correspondence.RESULTS: Four prospective studies matched the inclusion criteria. Analysis was performed on patient level data reaching a total of 759 patients and 887 vessels with paired FFR, QFR, and resting Pd/Pa. Median FFR was 0.85 (IQR: 0.77-0.90). Diagnostic accuracy of QFR with FFR as reference was higher if FFR corresponded to resting Pd/Pa: accuracy 90% (95% CI: 88-92) versus 72% (95% CI: 64-80), p < .001, and sAUC 0.95 (95% CI: 0.92-0.96) versus 0.73 (95% CI: 0.69-0.77), p < .001. Resting Pd/Pa and FFR discordance were related to age, sex, hypertension, and lesion severity.CONCLUSION: Diagnostic performance of QFR with FFR as reference is reduced for lesions with discordant FFR (≤0.80) and resting Pd/Pa (≤0.92) measurements.

U2 - 10.1002/ccd.28976

DO - 10.1002/ccd.28976

M3 - Journal article

C2 - 32478462

JO - Catheterization and Cardiovascular Interventions

JF - Catheterization and Cardiovascular Interventions

SN - 1522-1946

ER -