Residential exposure to transportation noise and risk of incident atrial fibrillation: a pooled study of 11 prospective Nordic cohorts

Jesse D. Thacher; Nina Roswall; Mikael Ögren; Andrei Pyko; Agneta Åkesson; Anna Oudin; Annika Rosengren; Aslak H. Poulsen; Charlotta Eriksson; David Segersson; Debora Rizzuto; Emilie Helte; Eva M. Andersson; Gunn Marit Aasvang; Gunnar Engström; Hrafnhildur Gudjonsdottir; Jenny Selander; Jesper H. Christensen; Jørgen Brandt; Karin Leander; Kim Overvad; Kristoffer Mattisson; Kristina Eneroth; Lara Stucki; Lars Barregard; Leo Stockfelt; Maria Albin; Mette K. Simonsen; Ole Raaschou-Nielsen; Pekka Jousilahti; Pekka Tiittanen; Petter L.S. Ljungman; Steen S. Jensen; Susanna Gustafsson; Tarja Yli-Tuomi; Thomas Cole-Hunter; Timo Lanki; Youn Hee Lim; Zorana J. Andersen; Göran Pershagen; Mette Sørensen

doi:10.1016/j.lanepe.2024.101091

Residential exposure to transportation noise and risk of incident atrial fibrillation: a pooled study of 11 prospective Nordic cohorts

Jesse D. Thacher^*, Nina Roswall, Mikael Ögren, Andrei Pyko, Agneta Åkesson, Anna Oudin, Annika Rosengren, Aslak H. Poulsen, Charlotta Eriksson, David Segersson, Debora Rizzuto, Emilie Helte, Eva M. Andersson, Gunn Marit Aasvang, Gunnar Engström, Hrafnhildur Gudjonsdottir, Jenny Selander, Jesper H. Christensen, Jørgen Brandt, Karin LeanderKim Overvad, Kristoffer Mattisson, Kristina Eneroth, Lara Stucki, Lars Barregard, Leo Stockfelt, Maria Albin, Mette K. Simonsen, Ole Raaschou-Nielsen, Pekka Jousilahti, Pekka Tiittanen, Petter L.S. Ljungman, Steen S. Jensen, Susanna Gustafsson, Tarja Yli-Tuomi, Thomas Cole-Hunter, Timo Lanki, Youn Hee Lim, Zorana J. Andersen, Göran Pershagen, Mette Sørensen

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

3 Citations (Scopus)

Abstract

Background: Transportation noise has been linked with cardiometabolic outcomes, yet whether it is a risk factor for atrial fibrillation (AF) remains inconclusive. We aimed to assess whether transportation noise was associated with AF in a large, pooled Nordic cohort. Methods: We pooled data from 11 Nordic cohorts, totaling 161,115 participants. Based on address history from five years before baseline until end of follow-up, road, railway, and aircraft noise was estimated at a residential level. Incident AF was ascertained via linkage to nationwide patient registries. Cox proportional hazards models were utilized to estimate associations between running 5-year time-weighted mean transportation noise (L_den) and AF after adjusting for sociodemographics, lifestyle, and air pollution. Findings: We identified 18,939 incident AF cases over a median follow-up of 19.6 years. Road traffic noise was associated with AF, with a hazard ratio (HR) and 95% confidence interval (CI) of 1.02 (1.00–1.04) per 10-dB of 5-year mean time-weighted exposure, which changed to 1.03 (1.01–1.06) when implementing a 53-dB cut-off. In effect modification analyses, the association for road traffic noise and AF appeared strongest in women and overweight and obese participants. Compared to exposures ≤40 dB, aircraft noise of 40.1–50 and > 50 dB were associated with HRs of 1.04 (0.93–1.16) and 1.12 (0.98–1.27), respectively. Railway noise was not associated with AF. We found a HR of 1.19 (1.02–1.40) among people exposed to noise from road (≥45 dB), railway (>40 dB), and aircraft (>40 dB) combined. Interpretation: Road traffic noise, and possibly aircraft noise, may be associated with elevated risk of AF. Funding: NordForsk.

Original language	English
Article number	101091
Journal	The Lancet Regional Health - Europe
Volume	46
ISSN	2666-7762
DOIs	https://doi.org/10.1016/j.lanepe.2024.101091
Publication status	Published - Nov 2024

Keywords

Air pollution
Aircraft noise
Arrhythmia
Atrial fibrillation
Cardiac
Pooled cohort
Railway noise
Road traffic noise

Access to Document

10.1016/j.lanepe.2024.101091

Cite this

Thacher, J. D., Roswall, N., Ögren, M., Pyko, A., Åkesson, A., Oudin, A., Rosengren, A., Poulsen, A. H., Eriksson, C., Segersson, D., Rizzuto, D., Helte, E., Andersson, E. M., Aasvang, G. M., Engström, G., Gudjonsdottir, H., Selander, J., Christensen, J. H., Brandt, J., ... Sørensen, M. (2024). Residential exposure to transportation noise and risk of incident atrial fibrillation: a pooled study of 11 prospective Nordic cohorts. The Lancet Regional Health - Europe, 46, Article 101091. https://doi.org/10.1016/j.lanepe.2024.101091

@article{eec7fb3fadee4c23a9fd409f7776b254,

title = "Residential exposure to transportation noise and risk of incident atrial fibrillation: a pooled study of 11 prospective Nordic cohorts",

abstract = "Background: Transportation noise has been linked with cardiometabolic outcomes, yet whether it is a risk factor for atrial fibrillation (AF) remains inconclusive. We aimed to assess whether transportation noise was associated with AF in a large, pooled Nordic cohort. Methods: We pooled data from 11 Nordic cohorts, totaling 161,115 participants. Based on address history from five years before baseline until end of follow-up, road, railway, and aircraft noise was estimated at a residential level. Incident AF was ascertained via linkage to nationwide patient registries. Cox proportional hazards models were utilized to estimate associations between running 5-year time-weighted mean transportation noise (Lden) and AF after adjusting for sociodemographics, lifestyle, and air pollution. Findings: We identified 18,939 incident AF cases over a median follow-up of 19.6 years. Road traffic noise was associated with AF, with a hazard ratio (HR) and 95% confidence interval (CI) of 1.02 (1.00–1.04) per 10-dB of 5-year mean time-weighted exposure, which changed to 1.03 (1.01–1.06) when implementing a 53-dB cut-off. In effect modification analyses, the association for road traffic noise and AF appeared strongest in women and overweight and obese participants. Compared to exposures ≤40 dB, aircraft noise of 40.1–50 and > 50 dB were associated with HRs of 1.04 (0.93–1.16) and 1.12 (0.98–1.27), respectively. Railway noise was not associated with AF. We found a HR of 1.19 (1.02–1.40) among people exposed to noise from road (≥45 dB), railway (>40 dB), and aircraft (>40 dB) combined. Interpretation: Road traffic noise, and possibly aircraft noise, may be associated with elevated risk of AF. Funding: NordForsk.",

keywords = "Air pollution, Aircraft noise, Arrhythmia, Atrial fibrillation, Cardiac, Pooled cohort, Railway noise, Road traffic noise",

author = "Thacher, {Jesse D.} and Nina Roswall and Mikael {\"O}gren and Andrei Pyko and Agneta {\AA}kesson and Anna Oudin and Annika Rosengren and Poulsen, {Aslak H.} and Charlotta Eriksson and David Segersson and Debora Rizzuto and Emilie Helte and Andersson, {Eva M.} and Aasvang, {Gunn Marit} and Gunnar Engstr{\"o}m and Hrafnhildur Gudjonsdottir and Jenny Selander and Christensen, {Jesper H.} and J{\o}rgen Brandt and Karin Leander and Kim Overvad and Kristoffer Mattisson and Kristina Eneroth and Lara Stucki and Lars Barregard and Leo Stockfelt and Maria Albin and Simonsen, {Mette K.} and Ole Raaschou-Nielsen and Pekka Jousilahti and Pekka Tiittanen and Ljungman, {Petter L.S.} and Jensen, {Steen S.} and Susanna Gustafsson and Tarja Yli-Tuomi and Thomas Cole-Hunter and Timo Lanki and Lim, {Youn Hee} and Andersen, {Zorana J.} and G{\"o}ran Pershagen and Mette S{\o}rensen",

year = "2024",

month = nov,

doi = "10.1016/j.lanepe.2024.101091",

language = "English",

volume = "46",

journal = "The Lancet Regional Health - Europe",

issn = "2666-7762",

publisher = "Elsevier",

}

Thacher, JD, Roswall, N, Ögren, M, Pyko, A, Åkesson, A, Oudin, A, Rosengren, A, Poulsen, AH, Eriksson, C, Segersson, D, Rizzuto, D, Helte, E, Andersson, EM, Aasvang, GM, Engström, G, Gudjonsdottir, H, Selander, J, Christensen, JH , Brandt, J, Leander, K, Overvad, K, Mattisson, K, Eneroth, K, Stucki, L, Barregard, L, Stockfelt, L, Albin, M, Simonsen, MK, Raaschou-Nielsen, O, Jousilahti, P, Tiittanen, P, Ljungman, PLS, Jensen, SS, Gustafsson, S, Yli-Tuomi, T, Cole-Hunter, T, Lanki, T, Lim, YH, Andersen, ZJ, Pershagen, G & Sørensen, M 2024, 'Residential exposure to transportation noise and risk of incident atrial fibrillation: a pooled study of 11 prospective Nordic cohorts', The Lancet Regional Health - Europe, vol. 46, 101091. https://doi.org/10.1016/j.lanepe.2024.101091

Residential exposure to transportation noise and risk of incident atrial fibrillation: a pooled study of 11 prospective Nordic cohorts. / Thacher, Jesse D.; Roswall, Nina; Ögren, Mikael et al.
In: The Lancet Regional Health - Europe, Vol. 46, 101091, 11.2024.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Residential exposure to transportation noise and risk of incident atrial fibrillation

T2 - a pooled study of 11 prospective Nordic cohorts

AU - Thacher, Jesse D.

AU - Roswall, Nina

AU - Ögren, Mikael

AU - Pyko, Andrei

AU - Åkesson, Agneta

AU - Oudin, Anna

AU - Rosengren, Annika

AU - Poulsen, Aslak H.

AU - Eriksson, Charlotta

AU - Segersson, David

AU - Rizzuto, Debora

AU - Helte, Emilie

AU - Andersson, Eva M.

AU - Aasvang, Gunn Marit

AU - Engström, Gunnar

AU - Gudjonsdottir, Hrafnhildur

AU - Selander, Jenny

AU - Christensen, Jesper H.

AU - Brandt, Jørgen

AU - Leander, Karin

AU - Overvad, Kim

AU - Mattisson, Kristoffer

AU - Eneroth, Kristina

AU - Stucki, Lara

AU - Barregard, Lars

AU - Stockfelt, Leo

AU - Albin, Maria

AU - Simonsen, Mette K.

AU - Raaschou-Nielsen, Ole

AU - Jousilahti, Pekka

AU - Tiittanen, Pekka

AU - Ljungman, Petter L.S.

AU - Jensen, Steen S.

AU - Gustafsson, Susanna

AU - Yli-Tuomi, Tarja

AU - Cole-Hunter, Thomas

AU - Lanki, Timo

AU - Lim, Youn Hee

AU - Andersen, Zorana J.

AU - Pershagen, Göran

AU - Sørensen, Mette

PY - 2024/11

Y1 - 2024/11

N2 - Background: Transportation noise has been linked with cardiometabolic outcomes, yet whether it is a risk factor for atrial fibrillation (AF) remains inconclusive. We aimed to assess whether transportation noise was associated with AF in a large, pooled Nordic cohort. Methods: We pooled data from 11 Nordic cohorts, totaling 161,115 participants. Based on address history from five years before baseline until end of follow-up, road, railway, and aircraft noise was estimated at a residential level. Incident AF was ascertained via linkage to nationwide patient registries. Cox proportional hazards models were utilized to estimate associations between running 5-year time-weighted mean transportation noise (Lden) and AF after adjusting for sociodemographics, lifestyle, and air pollution. Findings: We identified 18,939 incident AF cases over a median follow-up of 19.6 years. Road traffic noise was associated with AF, with a hazard ratio (HR) and 95% confidence interval (CI) of 1.02 (1.00–1.04) per 10-dB of 5-year mean time-weighted exposure, which changed to 1.03 (1.01–1.06) when implementing a 53-dB cut-off. In effect modification analyses, the association for road traffic noise and AF appeared strongest in women and overweight and obese participants. Compared to exposures ≤40 dB, aircraft noise of 40.1–50 and > 50 dB were associated with HRs of 1.04 (0.93–1.16) and 1.12 (0.98–1.27), respectively. Railway noise was not associated with AF. We found a HR of 1.19 (1.02–1.40) among people exposed to noise from road (≥45 dB), railway (>40 dB), and aircraft (>40 dB) combined. Interpretation: Road traffic noise, and possibly aircraft noise, may be associated with elevated risk of AF. Funding: NordForsk.

AB - Background: Transportation noise has been linked with cardiometabolic outcomes, yet whether it is a risk factor for atrial fibrillation (AF) remains inconclusive. We aimed to assess whether transportation noise was associated with AF in a large, pooled Nordic cohort. Methods: We pooled data from 11 Nordic cohorts, totaling 161,115 participants. Based on address history from five years before baseline until end of follow-up, road, railway, and aircraft noise was estimated at a residential level. Incident AF was ascertained via linkage to nationwide patient registries. Cox proportional hazards models were utilized to estimate associations between running 5-year time-weighted mean transportation noise (Lden) and AF after adjusting for sociodemographics, lifestyle, and air pollution. Findings: We identified 18,939 incident AF cases over a median follow-up of 19.6 years. Road traffic noise was associated with AF, with a hazard ratio (HR) and 95% confidence interval (CI) of 1.02 (1.00–1.04) per 10-dB of 5-year mean time-weighted exposure, which changed to 1.03 (1.01–1.06) when implementing a 53-dB cut-off. In effect modification analyses, the association for road traffic noise and AF appeared strongest in women and overweight and obese participants. Compared to exposures ≤40 dB, aircraft noise of 40.1–50 and > 50 dB were associated with HRs of 1.04 (0.93–1.16) and 1.12 (0.98–1.27), respectively. Railway noise was not associated with AF. We found a HR of 1.19 (1.02–1.40) among people exposed to noise from road (≥45 dB), railway (>40 dB), and aircraft (>40 dB) combined. Interpretation: Road traffic noise, and possibly aircraft noise, may be associated with elevated risk of AF. Funding: NordForsk.

KW - Air pollution

KW - Aircraft noise

KW - Arrhythmia

KW - Atrial fibrillation

KW - Cardiac

KW - Pooled cohort

KW - Railway noise

KW - Road traffic noise

UR - http://www.scopus.com/inward/record.url?scp=85205322497&partnerID=8YFLogxK

U2 - 10.1016/j.lanepe.2024.101091

DO - 10.1016/j.lanepe.2024.101091

M3 - Journal article

C2 - 39403081

AN - SCOPUS:85205322497

SN - 2666-7762

VL - 46

JO - The Lancet Regional Health - Europe

JF - The Lancet Regional Health - Europe

M1 - 101091

ER -

Residential exposure to transportation noise and risk of incident atrial fibrillation: a pooled study of 11 prospective Nordic cohorts

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this