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Renal resistance and long-term blood pressure in individuals genetically predisposed for essential hypertension: 10-year follow-up of the Danish Hypertension Prevention Project

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Renal resistance and long-term blood pressure in individuals genetically predisposed for essential hypertension: 10-year follow-up of the Danish Hypertension Prevention Project. / Buus, Niels H; Mulvany, Michael J; Eiskjær, Hans et al.
In: Journal of Hypertension, Vol. 34, No. 6, 06.2016, p. 1170-7.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Harvard

Buus, NH, Mulvany, MJ, Eiskjær, H, Christensen, KL & Skov, K 2016, 'Renal resistance and long-term blood pressure in individuals genetically predisposed for essential hypertension: 10-year follow-up of the Danish Hypertension Prevention Project', Journal of Hypertension, vol. 34, no. 6, pp. 1170-7. https://doi.org/10.1097/HJH.0000000000000919

APA

Buus, N. H., Mulvany, M. J., Eiskjær, H., Christensen, K. L., & Skov, K. (2016). Renal resistance and long-term blood pressure in individuals genetically predisposed for essential hypertension: 10-year follow-up of the Danish Hypertension Prevention Project. Journal of Hypertension, 34(6), 1170-7. https://doi.org/10.1097/HJH.0000000000000919

CBE

Buus NH, Mulvany MJ, Eiskjær H, Christensen KL, Skov K. 2016. Renal resistance and long-term blood pressure in individuals genetically predisposed for essential hypertension: 10-year follow-up of the Danish Hypertension Prevention Project. Journal of Hypertension. 34(6):1170-7. https://doi.org/10.1097/HJH.0000000000000919

MLA

Buus, Niels H et al. "Renal resistance and long-term blood pressure in individuals genetically predisposed for essential hypertension: 10-year follow-up of the Danish Hypertension Prevention Project". Journal of Hypertension. 2016, 34(6). 1170-7. https://doi.org/10.1097/HJH.0000000000000919

Vancouver

Buus NH, Mulvany MJ, Eiskjær H, Christensen KL, Skov K. Renal resistance and long-term blood pressure in individuals genetically predisposed for essential hypertension: 10-year follow-up of the Danish Hypertension Prevention Project. Journal of Hypertension. 2016 Jun;34(6):1170-7. doi: 10.1097/HJH.0000000000000919

Author

Buus, Niels H ; Mulvany, Michael J ; Eiskjær, Hans et al. / Renal resistance and long-term blood pressure in individuals genetically predisposed for essential hypertension : 10-year follow-up of the Danish Hypertension Prevention Project. In: Journal of Hypertension. 2016 ; Vol. 34, No. 6. pp. 1170-7.

Bibtex

@article{46b16c92fea44af684caedbbde0f34be,
title = "Renal resistance and long-term blood pressure in individuals genetically predisposed for essential hypertension: 10-year follow-up of the Danish Hypertension Prevention Project",
abstract = "AIM: Young individuals genetically predisposed for essential hypertension have increased renal vascular resistance. We evaluated whether 1 year of angiotensin II receptor blockade decreases afferent arteriolar resistance (RA) and induces a sustained blood pressure (BP) reduction during a 10-year follow-up period in offspring of parents both diagnosed with essential hypertension.METHODS: Based on renal plasma flow (p-aminohippurate clearance) and glomerular filtration rate (Cr-EDTA clearance) RA was calculated according to the model originally established by Gomez. Following baseline measurements, the participants (n = 110, mean age 30 years) were randomly allocated to 12 months of treatment with either candesartan or placebo followed by repetition of measurements and withdrawal of medication. Four-hour ambulatory BP (ABP) was recorded at baseline, by end of active treatment and after 6 months, 1, 2, 3, 5, and 10 years. ABP was analyzed according to RA achieved at the end of active treatment.RESULTS: Candesartan reduced RA by 14% (P < 0.01). Ten years posttreatment systolic ABP increased by 2.1 mmHg (P = 0.04) and diastolic by 4.2 mmHg (P < 0.01) compared with baseline, without any difference between treatment arms. A high posttreatment RA was associated with higher BP levels during follow-up, but long-term alterations in 24-h BP were similar in participants with low and high RA and not different between treatment arms.CONCLUSION: RA is associated with 24-h BP levels, but temporary lowering of BP and RA by candesartan does not prevent BP from increasing further. Prevention of hypertension appears not feasible by short-term inhibition of the rennin-angiotensin system in young adults.",
keywords = "afferent arterioles, ambulatory blood pressure measurement, blood pressure, essential hypertension, renal vascular resistance",
author = "Buus, {Niels H} and Mulvany, {Michael J} and Hans Eiskj{\ae}r and Christensen, {Kent L} and Karin Skov",
year = "2016",
month = jun,
doi = "10.1097/HJH.0000000000000919",
language = "English",
volume = "34",
pages = "1170--7",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams & Wilkins, Ltd.",
number = "6",

}

RIS

TY - JOUR

T1 - Renal resistance and long-term blood pressure in individuals genetically predisposed for essential hypertension

T2 - 10-year follow-up of the Danish Hypertension Prevention Project

AU - Buus, Niels H

AU - Mulvany, Michael J

AU - Eiskjær, Hans

AU - Christensen, Kent L

AU - Skov, Karin

PY - 2016/6

Y1 - 2016/6

N2 - AIM: Young individuals genetically predisposed for essential hypertension have increased renal vascular resistance. We evaluated whether 1 year of angiotensin II receptor blockade decreases afferent arteriolar resistance (RA) and induces a sustained blood pressure (BP) reduction during a 10-year follow-up period in offspring of parents both diagnosed with essential hypertension.METHODS: Based on renal plasma flow (p-aminohippurate clearance) and glomerular filtration rate (Cr-EDTA clearance) RA was calculated according to the model originally established by Gomez. Following baseline measurements, the participants (n = 110, mean age 30 years) were randomly allocated to 12 months of treatment with either candesartan or placebo followed by repetition of measurements and withdrawal of medication. Four-hour ambulatory BP (ABP) was recorded at baseline, by end of active treatment and after 6 months, 1, 2, 3, 5, and 10 years. ABP was analyzed according to RA achieved at the end of active treatment.RESULTS: Candesartan reduced RA by 14% (P < 0.01). Ten years posttreatment systolic ABP increased by 2.1 mmHg (P = 0.04) and diastolic by 4.2 mmHg (P < 0.01) compared with baseline, without any difference between treatment arms. A high posttreatment RA was associated with higher BP levels during follow-up, but long-term alterations in 24-h BP were similar in participants with low and high RA and not different between treatment arms.CONCLUSION: RA is associated with 24-h BP levels, but temporary lowering of BP and RA by candesartan does not prevent BP from increasing further. Prevention of hypertension appears not feasible by short-term inhibition of the rennin-angiotensin system in young adults.

AB - AIM: Young individuals genetically predisposed for essential hypertension have increased renal vascular resistance. We evaluated whether 1 year of angiotensin II receptor blockade decreases afferent arteriolar resistance (RA) and induces a sustained blood pressure (BP) reduction during a 10-year follow-up period in offspring of parents both diagnosed with essential hypertension.METHODS: Based on renal plasma flow (p-aminohippurate clearance) and glomerular filtration rate (Cr-EDTA clearance) RA was calculated according to the model originally established by Gomez. Following baseline measurements, the participants (n = 110, mean age 30 years) were randomly allocated to 12 months of treatment with either candesartan or placebo followed by repetition of measurements and withdrawal of medication. Four-hour ambulatory BP (ABP) was recorded at baseline, by end of active treatment and after 6 months, 1, 2, 3, 5, and 10 years. ABP was analyzed according to RA achieved at the end of active treatment.RESULTS: Candesartan reduced RA by 14% (P < 0.01). Ten years posttreatment systolic ABP increased by 2.1 mmHg (P = 0.04) and diastolic by 4.2 mmHg (P < 0.01) compared with baseline, without any difference between treatment arms. A high posttreatment RA was associated with higher BP levels during follow-up, but long-term alterations in 24-h BP were similar in participants with low and high RA and not different between treatment arms.CONCLUSION: RA is associated with 24-h BP levels, but temporary lowering of BP and RA by candesartan does not prevent BP from increasing further. Prevention of hypertension appears not feasible by short-term inhibition of the rennin-angiotensin system in young adults.

KW - afferent arterioles

KW - ambulatory blood pressure measurement

KW - blood pressure

KW - essential hypertension

KW - renal vascular resistance

U2 - 10.1097/HJH.0000000000000919

DO - 10.1097/HJH.0000000000000919

M3 - Journal article

C2 - 27054529

VL - 34

SP - 1170

EP - 1177

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 6

ER -