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Renal Autocrine and Paracrine Signaling: A Story of Self-protection

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Renal Autocrine and Paracrine Signaling : A Story of Self-protection. / Leipziger, Jens; Praetorius, Helle.

In: Physiological Reviews, Vol. 100, No. 3, 07.2020, p. 1229-1289.

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Leipziger, Jens ; Praetorius, Helle. / Renal Autocrine and Paracrine Signaling : A Story of Self-protection. In: Physiological Reviews. 2020 ; Vol. 100, No. 3. pp. 1229-1289.

Bibtex

@article{dd24e1f1bd81456cad5c08db6c7df890,
title = "Renal Autocrine and Paracrine Signaling: A Story of Self-protection",
abstract = "Autocrine and paracrine signaling in the kidney adds an extra level of diversity and complexity to renal physiology. The extensive scientific production on the topic precludes easy understanding of the fundamental purpose of the vast number of molecules and systems that influence the renal function. This systematic review provides the broader pen strokes for a collected image of renal paracrine signaling. First, we recapitulate the essence of each paracrine system one by one. Thereafter the single components are merged into an overarching physiological concept. The presented survey shows that despite the diversity in the web of paracrine factors, the collected effect on renal function may not be complicated after all. In essence, paracrine activation provides an intelligent system that perceives minor perturbations and reacts with a coordinated and integrated tissue response that relieves the work load from the renal epithelia and favors diuresis and natriuresis. We suggest that the overall function of paracrine signaling is reno-protection and argue that renal paracrine signaling and self-regulation are two sides of the same coin. Thus local paracrine signaling is an intrinsic function of the kidney, and the overall renal effect of changes in blood pressure, volume load, and systemic hormones will always be tinted by its paracrine status.",
keywords = "autoregulation, kidney, NaCl, paracrine, renoprotection, transport, water",
author = "Jens Leipziger and Helle Praetorius",
year = "2020",
month = jul,
doi = "10.1152/physrev.00014.2019",
language = "English",
volume = "100",
pages = "1229--1289",
journal = "Physiological Reviews",
issn = "0031-9333",
publisher = "American Physiological Society",
number = "3",

}

RIS

TY - JOUR

T1 - Renal Autocrine and Paracrine Signaling

T2 - A Story of Self-protection

AU - Leipziger, Jens

AU - Praetorius, Helle

PY - 2020/7

Y1 - 2020/7

N2 - Autocrine and paracrine signaling in the kidney adds an extra level of diversity and complexity to renal physiology. The extensive scientific production on the topic precludes easy understanding of the fundamental purpose of the vast number of molecules and systems that influence the renal function. This systematic review provides the broader pen strokes for a collected image of renal paracrine signaling. First, we recapitulate the essence of each paracrine system one by one. Thereafter the single components are merged into an overarching physiological concept. The presented survey shows that despite the diversity in the web of paracrine factors, the collected effect on renal function may not be complicated after all. In essence, paracrine activation provides an intelligent system that perceives minor perturbations and reacts with a coordinated and integrated tissue response that relieves the work load from the renal epithelia and favors diuresis and natriuresis. We suggest that the overall function of paracrine signaling is reno-protection and argue that renal paracrine signaling and self-regulation are two sides of the same coin. Thus local paracrine signaling is an intrinsic function of the kidney, and the overall renal effect of changes in blood pressure, volume load, and systemic hormones will always be tinted by its paracrine status.

AB - Autocrine and paracrine signaling in the kidney adds an extra level of diversity and complexity to renal physiology. The extensive scientific production on the topic precludes easy understanding of the fundamental purpose of the vast number of molecules and systems that influence the renal function. This systematic review provides the broader pen strokes for a collected image of renal paracrine signaling. First, we recapitulate the essence of each paracrine system one by one. Thereafter the single components are merged into an overarching physiological concept. The presented survey shows that despite the diversity in the web of paracrine factors, the collected effect on renal function may not be complicated after all. In essence, paracrine activation provides an intelligent system that perceives minor perturbations and reacts with a coordinated and integrated tissue response that relieves the work load from the renal epithelia and favors diuresis and natriuresis. We suggest that the overall function of paracrine signaling is reno-protection and argue that renal paracrine signaling and self-regulation are two sides of the same coin. Thus local paracrine signaling is an intrinsic function of the kidney, and the overall renal effect of changes in blood pressure, volume load, and systemic hormones will always be tinted by its paracrine status.

KW - autoregulation

KW - kidney

KW - NaCl

KW - paracrine

KW - renoprotection

KW - transport

KW - water

UR - http://www.scopus.com/inward/record.url?scp=85084693344&partnerID=8YFLogxK

U2 - 10.1152/physrev.00014.2019

DO - 10.1152/physrev.00014.2019

M3 - Journal article

C2 - 31999508

AN - SCOPUS:85084693344

VL - 100

SP - 1229

EP - 1289

JO - Physiological Reviews

JF - Physiological Reviews

SN - 0031-9333

IS - 3

ER -