TY - JOUR
T1 - Remotely Triggered Liquefaction of Hydrogel Materials
AU - Pedersen, Søren L.
AU - Huynh, Tin H.
AU - Pöschko, Philipp
AU - Fruergaard, Anne Sofie
AU - Jarlstad Olesen, Morten T.
AU - Chen, Yaqing
AU - Birkedal, Henrik
AU - Subbiahdoss, Guruprakash
AU - Reimhult, Erik
AU - Thøgersen, Jan
AU - Zelikin, Alexander N.
PY - 2020/7
Y1 - 2020/7
N2 - Adaptable behavior such as triggered disintegration affords a broad scope and utility for (bio)materials in diverse applications in materials science and engineering. The impact of such materials continues to grow due to the increased importance of environmental considerations as well as the increased use of implants in medical practices. However, examples of such materials are still few. In this work, we engineer triggered liquefaction of hydrogel biomaterials in response to internal, localized heating, mediated by near-infrared light as external stimulus. This adaptable behavior is engineered into the readily available physical hydrogels based on poly(vinyl alcohol), using gold nanoparticles or an organic photothermal dye as heat generators. Upon laser light irradiation, engineered biomaterials underwent liquefaction within seconds. Pulsed laser light irradiation afforded controlled, on-demand release of the incorporated cargo, successful for small molecules as well as proteins (enzymes) in their biofunctional form.
AB - Adaptable behavior such as triggered disintegration affords a broad scope and utility for (bio)materials in diverse applications in materials science and engineering. The impact of such materials continues to grow due to the increased importance of environmental considerations as well as the increased use of implants in medical practices. However, examples of such materials are still few. In this work, we engineer triggered liquefaction of hydrogel biomaterials in response to internal, localized heating, mediated by near-infrared light as external stimulus. This adaptable behavior is engineered into the readily available physical hydrogels based on poly(vinyl alcohol), using gold nanoparticles or an organic photothermal dye as heat generators. Upon laser light irradiation, engineered biomaterials underwent liquefaction within seconds. Pulsed laser light irradiation afforded controlled, on-demand release of the incorporated cargo, successful for small molecules as well as proteins (enzymes) in their biofunctional form.
KW - biomaterials
KW - hydrogels
KW - nanoparticles
KW - remote activation
KW - stimuli response
UR - http://www.scopus.com/inward/record.url?scp=85089098993&partnerID=8YFLogxK
U2 - 10.1021/acsnano.0c04522
DO - 10.1021/acsnano.0c04522
M3 - Journal article
C2 - 32615036
AN - SCOPUS:85089098993
SN - 1936-0851
VL - 14
SP - 9145
EP - 9155
JO - ACS Nano
JF - ACS Nano
IS - 7
ER -