Remotely Triggered Liquefaction of Hydrogel Materials

Søren L. Pedersen; Tin H. Huynh; Philipp Pöschko; Anne Sofie Fruergaard; Morten T. Jarlstad Olesen; Yaqing Chen; Henrik Birkedal; Guruprakash Subbiahdoss; Erik Reimhult; Jan Thøgersen; Alexander N. Zelikin

doi:10.1021/acsnano.0c04522

Remotely Triggered Liquefaction of Hydrogel Materials

Søren L. Pedersen, Tin H. Huynh, Philipp Pöschko, Anne Sofie Fruergaard, Morten T. Jarlstad Olesen, Yaqing Chen, Henrik Birkedal, Guruprakash Subbiahdoss, Erik Reimhult, Jan Thøgersen, Alexander N. Zelikin^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

39 Citations (Scopus)

Abstract

Adaptable behavior such as triggered disintegration affords a broad scope and utility for (bio)materials in diverse applications in materials science and engineering. The impact of such materials continues to grow due to the increased importance of environmental considerations as well as the increased use of implants in medical practices. However, examples of such materials are still few. In this work, we engineer triggered liquefaction of hydrogel biomaterials in response to internal, localized heating, mediated by near-infrared light as external stimulus. This adaptable behavior is engineered into the readily available physical hydrogels based on poly(vinyl alcohol), using gold nanoparticles or an organic photothermal dye as heat generators. Upon laser light irradiation, engineered biomaterials underwent liquefaction within seconds. Pulsed laser light irradiation afforded controlled, on-demand release of the incorporated cargo, successful for small molecules as well as proteins (enzymes) in their biofunctional form.

Original language	English
Journal	ACS Nano
Volume	14
Issue	7
Pages (from-to)	9145-9155
Number of pages	11
ISSN	1936-0851
DOIs	https://doi.org/10.1021/acsnano.0c04522
Publication status	Published - Jul 2020

Keywords

biomaterials
hydrogels
nanoparticles
remote activation
stimuli response

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10.1021/acsnano.0c04522

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title = "Remotely Triggered Liquefaction of Hydrogel Materials",

abstract = "Adaptable behavior such as triggered disintegration affords a broad scope and utility for (bio)materials in diverse applications in materials science and engineering. The impact of such materials continues to grow due to the increased importance of environmental considerations as well as the increased use of implants in medical practices. However, examples of such materials are still few. In this work, we engineer triggered liquefaction of hydrogel biomaterials in response to internal, localized heating, mediated by near-infrared light as external stimulus. This adaptable behavior is engineered into the readily available physical hydrogels based on poly(vinyl alcohol), using gold nanoparticles or an organic photothermal dye as heat generators. Upon laser light irradiation, engineered biomaterials underwent liquefaction within seconds. Pulsed laser light irradiation afforded controlled, on-demand release of the incorporated cargo, successful for small molecules as well as proteins (enzymes) in their biofunctional form. ",

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AU - Pedersen, Søren L.

AU - Huynh, Tin H.

AU - Pöschko, Philipp

AU - Fruergaard, Anne Sofie

AU - Jarlstad Olesen, Morten T.

AU - Chen, Yaqing

AU - Birkedal, Henrik

AU - Subbiahdoss, Guruprakash

AU - Reimhult, Erik

AU - Thøgersen, Jan

AU - Zelikin, Alexander N.

PY - 2020/7

Y1 - 2020/7

N2 - Adaptable behavior such as triggered disintegration affords a broad scope and utility for (bio)materials in diverse applications in materials science and engineering. The impact of such materials continues to grow due to the increased importance of environmental considerations as well as the increased use of implants in medical practices. However, examples of such materials are still few. In this work, we engineer triggered liquefaction of hydrogel biomaterials in response to internal, localized heating, mediated by near-infrared light as external stimulus. This adaptable behavior is engineered into the readily available physical hydrogels based on poly(vinyl alcohol), using gold nanoparticles or an organic photothermal dye as heat generators. Upon laser light irradiation, engineered biomaterials underwent liquefaction within seconds. Pulsed laser light irradiation afforded controlled, on-demand release of the incorporated cargo, successful for small molecules as well as proteins (enzymes) in their biofunctional form.

AB - Adaptable behavior such as triggered disintegration affords a broad scope and utility for (bio)materials in diverse applications in materials science and engineering. The impact of such materials continues to grow due to the increased importance of environmental considerations as well as the increased use of implants in medical practices. However, examples of such materials are still few. In this work, we engineer triggered liquefaction of hydrogel biomaterials in response to internal, localized heating, mediated by near-infrared light as external stimulus. This adaptable behavior is engineered into the readily available physical hydrogels based on poly(vinyl alcohol), using gold nanoparticles or an organic photothermal dye as heat generators. Upon laser light irradiation, engineered biomaterials underwent liquefaction within seconds. Pulsed laser light irradiation afforded controlled, on-demand release of the incorporated cargo, successful for small molecules as well as proteins (enzymes) in their biofunctional form.

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KW - hydrogels

KW - nanoparticles

KW - remote activation

KW - stimuli response

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Remotely Triggered Liquefaction of Hydrogel Materials

Abstract

Keywords

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