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Relationship of leukaemias with long-term ambient air pollution exposures in the adult Danish population

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Relationship of leukaemias with long-term ambient air pollution exposures in the adult Danish population. / Puett, Robin; Harbo Poulsen, Aslak; Taj, Tahir et al.
In: British Journal of Cancer, Vol. 123, No. 12, 12.2020, p. 1818-1824.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Harvard

Puett, R, Harbo Poulsen, A, Taj, T, Ketzel, M, Geels, C, Brandt, J, Christensen, JH, Sørensen, M, Roswall, N, Arthur Hvidtfeldt, U & Raaschou-Nielsen, O 2020, 'Relationship of leukaemias with long-term ambient air pollution exposures in the adult Danish population', British Journal of Cancer, vol. 123, no. 12, pp. 1818-1824. https://doi.org/10.1038/s41416-020-01058-2

APA

Puett, R., Harbo Poulsen, A., Taj, T., Ketzel, M., Geels, C., Brandt, J., Christensen, J. H., Sørensen, M., Roswall, N., Arthur Hvidtfeldt, U., & Raaschou-Nielsen, O. (2020). Relationship of leukaemias with long-term ambient air pollution exposures in the adult Danish population. British Journal of Cancer, 123(12), 1818-1824. Advance online publication. https://doi.org/10.1038/s41416-020-01058-2

CBE

Puett R, Harbo Poulsen A, Taj T, Ketzel M, Geels C, Brandt J, Christensen JH, Sørensen M, Roswall N, Arthur Hvidtfeldt U, et al. 2020. Relationship of leukaemias with long-term ambient air pollution exposures in the adult Danish population. British Journal of Cancer. 123(12):1818-1824. https://doi.org/10.1038/s41416-020-01058-2

MLA

Puett, Robin et al. "Relationship of leukaemias with long-term ambient air pollution exposures in the adult Danish population". British Journal of Cancer. 2020, 123(12). 1818-1824. https://doi.org/10.1038/s41416-020-01058-2

Vancouver

Puett R, Harbo Poulsen A, Taj T, Ketzel M, Geels C, Brandt J et al. Relationship of leukaemias with long-term ambient air pollution exposures in the adult Danish population. British Journal of Cancer. 2020 Dec;123(12):1818-1824. Epub 2020. doi: 10.1038/s41416-020-01058-2

Author

Puett, Robin ; Harbo Poulsen, Aslak ; Taj, Tahir et al. / Relationship of leukaemias with long-term ambient air pollution exposures in the adult Danish population. In: British Journal of Cancer. 2020 ; Vol. 123, No. 12. pp. 1818-1824.

Bibtex

@article{dce5d99f02914e8f9f4ed5862e5fe383,
title = "Relationship of leukaemias with long-term ambient air pollution exposures in the adult Danish population",
abstract = "BACKGROUND: Few population-based epidemiological studies of adults have examined the relationship between air pollution andleukaemias.METHODS: Using Danish National Cancer Registry data and Danish DEHM-UBM-AirGIS system-modelled air pollution exposures, weexamined whether particulate matter (PM2.5), black carbon (BC), nitrogen dioxide (NO2) and ozone (O3) averaged over 1, 5 or 10years were associated with adult leukaemia in general or by subtype. In all, 14,986 adult cases diagnosed 1989–2014 and 51,624age, sex and time-matched controls were included. Separate conditional logistic regression models, adjusted for sociodemographicfactors, assessed exposure to each pollutant with leukaemias.RESULTS: Fully adjusted models showed a higher risk of leukaemia with higher 1-, 5- and 10-year-average exposures to PM2.5 priorto diagnosis (e.g. OR per 10 μg/m3 for 10-year average: 1.17, 95% CI: 1.03, 1.32), and a positive relationship with 1-year average BC.Results were driven by participants 70 years and older (OR per 10 μg/m3 for 10-year average: 1.35, 95% CI: 1.15–1.58). Null findingsfor younger participants. Higher 1-year average PM2.5 exposures were associated with higher risks for acute myeloid and chroniclymphoblastic leukaemia.CONCLUSION: Among older adults, higher risk for leukaemia was associated with higher residential PM2.5 concentrations averagedover 1, 5 and 10 years prior to diagnosis.",
author = "Robin Puett and {Harbo Poulsen}, Aslak and Tahir Taj and Matthias Ketzel and Camilla Geels and J{\o}rgen Brandt and Christensen, {Jesper Heile} and Mette S{\o}rensen and Nina Roswall and {Arthur Hvidtfeldt}, Ulla and Ole Raaschou-Nielsen",
year = "2020",
month = dec,
doi = "10.1038/s41416-020-01058-2",
language = "English",
volume = "123",
pages = "1818--1824",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "12",

}

RIS

TY - JOUR

T1 - Relationship of leukaemias with long-term ambient air pollution exposures in the adult Danish population

AU - Puett, Robin

AU - Harbo Poulsen, Aslak

AU - Taj, Tahir

AU - Ketzel, Matthias

AU - Geels, Camilla

AU - Brandt, Jørgen

AU - Christensen, Jesper Heile

AU - Sørensen, Mette

AU - Roswall, Nina

AU - Arthur Hvidtfeldt, Ulla

AU - Raaschou-Nielsen, Ole

PY - 2020/12

Y1 - 2020/12

N2 - BACKGROUND: Few population-based epidemiological studies of adults have examined the relationship between air pollution andleukaemias.METHODS: Using Danish National Cancer Registry data and Danish DEHM-UBM-AirGIS system-modelled air pollution exposures, weexamined whether particulate matter (PM2.5), black carbon (BC), nitrogen dioxide (NO2) and ozone (O3) averaged over 1, 5 or 10years were associated with adult leukaemia in general or by subtype. In all, 14,986 adult cases diagnosed 1989–2014 and 51,624age, sex and time-matched controls were included. Separate conditional logistic regression models, adjusted for sociodemographicfactors, assessed exposure to each pollutant with leukaemias.RESULTS: Fully adjusted models showed a higher risk of leukaemia with higher 1-, 5- and 10-year-average exposures to PM2.5 priorto diagnosis (e.g. OR per 10 μg/m3 for 10-year average: 1.17, 95% CI: 1.03, 1.32), and a positive relationship with 1-year average BC.Results were driven by participants 70 years and older (OR per 10 μg/m3 for 10-year average: 1.35, 95% CI: 1.15–1.58). Null findingsfor younger participants. Higher 1-year average PM2.5 exposures were associated with higher risks for acute myeloid and chroniclymphoblastic leukaemia.CONCLUSION: Among older adults, higher risk for leukaemia was associated with higher residential PM2.5 concentrations averagedover 1, 5 and 10 years prior to diagnosis.

AB - BACKGROUND: Few population-based epidemiological studies of adults have examined the relationship between air pollution andleukaemias.METHODS: Using Danish National Cancer Registry data and Danish DEHM-UBM-AirGIS system-modelled air pollution exposures, weexamined whether particulate matter (PM2.5), black carbon (BC), nitrogen dioxide (NO2) and ozone (O3) averaged over 1, 5 or 10years were associated with adult leukaemia in general or by subtype. In all, 14,986 adult cases diagnosed 1989–2014 and 51,624age, sex and time-matched controls were included. Separate conditional logistic regression models, adjusted for sociodemographicfactors, assessed exposure to each pollutant with leukaemias.RESULTS: Fully adjusted models showed a higher risk of leukaemia with higher 1-, 5- and 10-year-average exposures to PM2.5 priorto diagnosis (e.g. OR per 10 μg/m3 for 10-year average: 1.17, 95% CI: 1.03, 1.32), and a positive relationship with 1-year average BC.Results were driven by participants 70 years and older (OR per 10 μg/m3 for 10-year average: 1.35, 95% CI: 1.15–1.58). Null findingsfor younger participants. Higher 1-year average PM2.5 exposures were associated with higher risks for acute myeloid and chroniclymphoblastic leukaemia.CONCLUSION: Among older adults, higher risk for leukaemia was associated with higher residential PM2.5 concentrations averagedover 1, 5 and 10 years prior to diagnosis.

U2 - 10.1038/s41416-020-01058-2

DO - 10.1038/s41416-020-01058-2

M3 - Journal article

C2 - 32939055

VL - 123

SP - 1818

EP - 1824

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 12

ER -