Regulation of the Drosophila Imd pathway by signaling amyloids

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Standard

Regulation of the Drosophila Imd pathway by signaling amyloids. / Kleino, Anni Paulina; Silverman, Neal.

In: Insect Biochemistry and Molecular Biology, Vol. 108, No. May, 2019, p. 16-23.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Harvard

Kleino, AP & Silverman, N 2019, 'Regulation of the Drosophila Imd pathway by signaling amyloids', Insect Biochemistry and Molecular Biology, vol. 108, no. May, pp. 16-23. https://doi.org/10.1016/j.ibmb.2019.03.003

APA

Kleino, A. P., & Silverman, N. (2019). Regulation of the Drosophila Imd pathway by signaling amyloids. Insect Biochemistry and Molecular Biology, 108(May), 16-23. https://doi.org/10.1016/j.ibmb.2019.03.003

CBE

Kleino AP, Silverman N. 2019. Regulation of the Drosophila Imd pathway by signaling amyloids. Insect Biochemistry and Molecular Biology. 108(May):16-23. https://doi.org/10.1016/j.ibmb.2019.03.003

MLA

Kleino, Anni Paulina and Neal Silverman. "Regulation of the Drosophila Imd pathway by signaling amyloids". Insect Biochemistry and Molecular Biology. 2019, 108(May). 16-23. https://doi.org/10.1016/j.ibmb.2019.03.003

Vancouver

Kleino AP, Silverman N. Regulation of the Drosophila Imd pathway by signaling amyloids. Insect Biochemistry and Molecular Biology. 2019;108(May):16-23. https://doi.org/10.1016/j.ibmb.2019.03.003

Author

Kleino, Anni Paulina ; Silverman, Neal. / Regulation of the Drosophila Imd pathway by signaling amyloids. In: Insect Biochemistry and Molecular Biology. 2019 ; Vol. 108, No. May. pp. 16-23.

Bibtex

@article{1f4d7e06eb2045b58aaa88cac9d34360,
title = "Regulation of the Drosophila Imd pathway by signaling amyloids",
abstract = "Fruit flies elicit effective defense responses against numerous microbes. The responses against Gram-negative bacteria are mediated by the Imd pathway, an evolutionarily conserved NF-κB pathway recognizing meso-diaminopimelic acid (DAP)-type peptidoglycan from bacterial cell walls. Several reviews already provide a detailed view of ligand recognition and signal transduction during Imd signaling, but the formation and regulation of the signaling complex immediately downstream of the peptidoglycan-sensing receptors is still elusive. In this review, we focus on the formation of the Imd amyloidal signaling center and post-translational modifications in the assembly and disassembly of the Imd signaling complex.",
keywords = "Drosophila immunity, Imd signaling, functional amyloid",
author = "Kleino, {Anni Paulina} and Neal Silverman",
year = "2019",
doi = "10.1016/j.ibmb.2019.03.003",
language = "English",
volume = "108",
pages = "16--23",
journal = "Insect Biochemistry and Molecular Biology",
issn = "0965-1748",
publisher = "Pergamon Press",
number = "May",

}

RIS

TY - JOUR

T1 - Regulation of the Drosophila Imd pathway by signaling amyloids

AU - Kleino, Anni Paulina

AU - Silverman, Neal

PY - 2019

Y1 - 2019

N2 - Fruit flies elicit effective defense responses against numerous microbes. The responses against Gram-negative bacteria are mediated by the Imd pathway, an evolutionarily conserved NF-κB pathway recognizing meso-diaminopimelic acid (DAP)-type peptidoglycan from bacterial cell walls. Several reviews already provide a detailed view of ligand recognition and signal transduction during Imd signaling, but the formation and regulation of the signaling complex immediately downstream of the peptidoglycan-sensing receptors is still elusive. In this review, we focus on the formation of the Imd amyloidal signaling center and post-translational modifications in the assembly and disassembly of the Imd signaling complex.

AB - Fruit flies elicit effective defense responses against numerous microbes. The responses against Gram-negative bacteria are mediated by the Imd pathway, an evolutionarily conserved NF-κB pathway recognizing meso-diaminopimelic acid (DAP)-type peptidoglycan from bacterial cell walls. Several reviews already provide a detailed view of ligand recognition and signal transduction during Imd signaling, but the formation and regulation of the signaling complex immediately downstream of the peptidoglycan-sensing receptors is still elusive. In this review, we focus on the formation of the Imd amyloidal signaling center and post-translational modifications in the assembly and disassembly of the Imd signaling complex.

KW - Drosophila immunity, Imd signaling, functional amyloid

U2 - 10.1016/j.ibmb.2019.03.003

DO - 10.1016/j.ibmb.2019.03.003

M3 - Review

C2 - 30857831

VL - 108

SP - 16

EP - 23

JO - Insect Biochemistry and Molecular Biology

JF - Insect Biochemistry and Molecular Biology

SN - 0965-1748

IS - May

ER -