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Regulation of the Drosophila Imd pathway by signaling amyloids

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  • Anni Paulina Kleino
  • ,
  • Neal Silverman, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, United States
Fruit flies elicit effective defense responses against numerous microbes. The responses against Gram-negative bacteria are mediated by the Imd pathway, an evolutionarily conserved NF-κB pathway recognizing meso-diaminopimelic acid (DAP)-type peptidoglycan from bacterial cell walls. Several reviews already provide a detailed view of ligand recognition and signal transduction during Imd signaling, but the formation and regulation of the signaling complex immediately downstream of the peptidoglycan-sensing receptors is still elusive. In this review, we focus on the formation of the Imd amyloidal signaling center and post-translational modifications in the assembly and disassembly of the Imd signaling complex.
Original languageEnglish
JournalInsect Biochemistry and Molecular Biology
Pages (from-to)16-23
Number of pages8
Publication statusPublished - 2019

    Research areas

  • Drosophila immunity, Imd signaling, functional amyloid

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