Regulation of the Drosophila Imd pathway by signaling amyloids

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Documents

DOI

  • Anni Paulina Kleino
  • ,
  • Neal Silverman, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, United States
Fruit flies elicit effective defense responses against numerous microbes. The responses against Gram-negative bacteria are mediated by the Imd pathway, an evolutionarily conserved NF-κB pathway recognizing meso-diaminopimelic acid (DAP)-type peptidoglycan from bacterial cell walls. Several reviews already provide a detailed view of ligand recognition and signal transduction during Imd signaling, but the formation and regulation of the signaling complex immediately downstream of the peptidoglycan-sensing receptors is still elusive. In this review, we focus on the formation of the Imd amyloidal signaling center and post-translational modifications in the assembly and disassembly of the Imd signaling complex.
Original languageEnglish
JournalInsect Biochemistry and Molecular Biology
Volume108
IssueMay
Pages (from-to)16-23
Number of pages8
ISSN0965-1748
DOIs
Publication statusPublished - 2019

    Research areas

  • Drosophila immunity, Imd signaling, functional amyloid

See relations at Aarhus University Citationformats

Download statistics

No data available

ID: 142327426